COVID-19 Evidence Reviews
as of 7/10/20
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Our goal of cataloging COVID-19 evidence reviews is to capture the work of evidence synthesis groups in the US and around the world to maximize our collective contributions to patients, frontline clinicians, researchers, and policymakers during the COVID-19 pandemic and avoid duplicating efforts. This catalog is maintained by staff at the VA Evidence Synthesis Program based in Portland, OR. We identify new evidence reviews and reviews in progress through literature searching and through correspondence with colleagues and content experts. We welcome your feedback and questions; please reach out to us at covid19reviews@gmail.com
Completed Reviews
 
= living review
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
latest update
report
7/10/20
STUDY REVIEW: Famotidine u
Lewis J, Mackey K | VA Evidence Synthesis Program
Aim: To critically appraise the identified study and provide additional context for study findings.
VA ESP
7/9/20
A Systematic Review of CT
Shao JM, Ayuso SA, Deerenberg EB, et al. | Colorectal Dis
Aim: To investigate the sensitivity and utility of computed tomography (CT) of the chest in diagnosing active Coronavirus 2019 (COVID?19) infection, and its potential application to the surgical setting.
7/9/20
Current smoking, former sm
Farsalinos K, Barbouni A, Poulas K, et al. | Ther Adv Chronic Dis
Aim: To examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients.
7/9/20
Pregnancy and COVID-19: A
Trocado V, Silvestre-Machado J, Azevedo L, et al. | J Matern Fetal Neonatal Med
Aim: To evaluate the impact of COVID-19 during pregnancy.
7/9/20
Venous thromboembolism in
Fontana P, Casini A, Robert-Ebadi H, et al. | Swiss Med Wkly
Aim: To summarise the reported risk of VTE associated with COVID-19 infections and to summarise guidance documents on thromboprophylaxis in COVID-19 patients, in a systematic review.
7/8/20
A comparison of mortality-
Lvliang L, Zhong W, Bian Z, et al. | J Infect
Aim: To compare mortality risk factors of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) to provide new strategies for COVID-19 prevention and treatment.
7/8/20
Coronavirus disease (COVID
Nandy K, Salunke A, Pathak SK, et al. | Diabetes Metab Syndr
Aim: To evaluate the impact of various morbidities on serious events in COVID 19.
7/8/20
Cutaneous Manifestations a
Seirafianpour F, Sodagar S, Mohammad AP, et al. | Dermatol Ther
Aim: To present an overview of suggestive skin manifestations of the COVID-19 and to address several considerations in the dermatological issues practices, during this pandemic.
7/8/20
Potential effective treatm
Sun M, Xu Y, He H, et al. | Int J Infect Dis
Aim: To explore the effectiveness of treatment and predict the potential effect of convalescent plasma for COVID-19.
7/8/20
Prevalence of stress, anxi
Salari N, Hosseinian-Far A, Jalali R, et al. | Global Health
Aim: To analyze the existing research works and findings in relation to the prevalence of stress, anxiety and depression in the general population during the COVID-19 pandemic.
7/8/20
Systematic review of the r
Zhu R, Gao Y, Robert S, et al. | J Transl Med
Aim: To summarize the characteristics of clinical trials for COVID-19.
7/8/20
Systematic Review With Met
Kulkarni A, Kumar P, Tevethia HV, et al. | Aliment Pharmacol Ther
Aim: To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID-19.
RECENTLY UPDATED
7/8/20
The impact of ethnicity on
Pan D, Sze S, Minhas J, et al. | EClinicalMedicine
Aim: To assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes.
RECENTLY UPDATED
7/7/20
Gastrointestinal involveme
Rokkas T | Ann Gastroenterol
Aim: To review the evidence on the involvement of the digestive system in COVID-19.
7/7/20
Spread and Impact of COVID
Lin Y, Duan Q, Zhou Y, et al. | Front Med
Aim: To review existing mathematical and statistical models and build a mathematical model to estimate the transmission capacity, epidemiological characteristics, potential peak time and size, and elimination time of COVID-19.
7/6/20
Chinese herbal medicine fo
Xiong X, Wang P, Su K, et al. | Pharmacol Res
Aim: To evaluate the current clinical evidence on Chinese herbal medicine for the treatment of COVID-19.
7/6/20
Coronavirus Disease (COVID
Kumar-M P, Mishra S, Jha DK, et al. | Hepatol Int
Aim: To systematically study the occurrence of liver injury in COVID-19 and also determine the frequency of liver involvement in COVID-19.
RECENTLY UPDATED
7/6/20
Self-reported alteration o
Borsetto D, Hopkins C, Philips V, et al. | Rhinology
Aim: To systematically assess the prevalence of self-reported altered sense of smell or taste in patients with confirmed SARS-CoV-2 infection.
7/6/20
The incidence of the novel
Al-Sadeq DW, Nasrallah GK | Int J Infect Dis
Aim: To systematically review the published literature on SARS-CoV-2 in the asymptomatic patients to estimate the incidence of COVID-19 among asymptomatic cases, as well as describe its epidemiological and clinical significance.
7/4/20
The Incidence and Outcomes
Aziz M, Fatima R, Haghbin H, et al. | Inflamm Bowel Dis
Aim: To better understand the incidence and outcomes of COVID-19 in infammatory bowel disease (IBD) patients.
7/3/20
Diagnostic Accuracy of Ser
Bastos M, Tavaziva G, Abidi SK, et al. | BMJ
Aim: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).
RECENTLY UPDATED
7/3/20
Efficacy and safety of umi
Huang D, Yu H, Wang T, et al. | J Med Virol
Aim: To evaluate the efficacy and safety of umifenovir in COVID?19.
7/3/20
Environmental Weather Cond
Spencer EA, Brassey J, Jefferson T, et al. | Oxford COVID-19 Evidence Service Team
Aim: To explore if climate conditions may influence the spread of SARS-CoV-2.
RECENTLY UPDATED
7/3/20
Interventions for healthca
Russo B, Iudici M | Infect Control Hosp Epidemiol
Aim: To provide a summary of preventative or therapeutic interventions specifically designed for healthcare workers facing with COVID-19 pandemic.
7/3/20
The Accuracy of Haemoglobi
Amaefule CE, Sasitharan A, Kalra P, et al. | Curr Opin Obstet Gynecol
Aim: To review the evidence on the screening and diagnostic accuracy of the haemoglobin A1c (HbA1c) test in women with and without risk factors for gestational diabetes.
7/3/20
The use of renin angiotens
Pranata R, Permana H, Huang I, et al. | Diabetes Metab Syndr
Aim: To investigate the association between use of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-receptor blocker (ARB) and outcomes of hypertensive COVID-19 patients.
7/2/20
Acute Complications and Mo
Potere N, Valeriani E, Candeloro M, et al. | Crit Care
Aim: To summarize the evidence on clinically relevant outcomes in hospitalized patients with COVID-19.
7/1/20
Comparison of the computed
Altmayer S, Zanon M, Pacini GS, et al. | Eur Radiol
Aim: To compare the chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) to other non-COVID viral pneumonia.
CLINICAL CHARACTERISTICS
7/1/20
Epidemiological and Clinic
Koh J, Shah SU, Chua PEY, et al. | Front Med
Aim: To review the epidemiological and clinical characteristics of COVID-19 cases in the early phase of the COVID-19 pandemic.
CLINICAL CHARACTERISTICS
7/1/20
Neuroimaging findings in C
Katal S, Balakrishnan S, Gholamrexanezhad A | J Neuroradiol
Aim: To review the available imaging findings of patients diagnosed with neurological symptoms associated with coronavirus infections.
CLINICAL CHARACTERISTICS
7/1/20
Obesity aggravates COVID-1
Yang J, Hu J, Zhu C | J Med Virol
Aim: To explore the relationship between obesity and COVID-19.
CLINICAL CHARACTERISTICS
7/1/20
Systematic Review and Meta
Alizadeh F, Khodavandi A | IEEE Trans Nanobioscience
Aim: To summarize the available evidence on the efficacy of nanoscale materials against coronaviruses in vitro and in animal models.
CANDIDATE THERAPEUTICS
6/30/20
Best practices for persona
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the best practices for personal care workers providing home care in the context of COVID-19.
6/30/20
Duration of Respiratory an
Hu CLH, Raval M, Schnall JA, et al. | Pediatr Infect Dis J
Aim: To determine the average shedding times of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via the respiratory and gastrointestinal tracts in children.
6/30/20
Medical and Epidemiologica
Khalili M, Karamouzian M, Nasiri N, et al. | Epidemiol Infect
Aim: To synthesize case fatality rate (CFR) among confirmed COVID-19 patients, incubation period, and time from onset of COVID-19 symptoms to first medical visit, intensive care unit (ICU) admission, recovery and death.
CLINICAL CHARACTERISTICS
6/30/20
Outcomes From Intensive Ca
Armstrong RA, Kane AD, Cook TM | Anaesthesia
Aim: To assess the reported ICU mortality for patients with confirmed COVID?19.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
6/29/20
The role of children in tr
Li X, Xu W, Dozier M, et al. | J Glob Health
Aim: To synthesise the latest evidence in relation to the role of children in the transmission of SARS-CoV-2.
6/28/20
COVID?19 and cutaneous man
Zhao Q, Fang X, Pang Z, et al. | J Eur Acad Dermatol Venereol
Aim: To gain an in-depth understanding of COVID-19 by summarizing publications related to the cutaneous manifestations of the disease and the ACE2 expression in skin tissues.
CLINICAL CHARACTERISTICS
6/27/20
Cutaneous manifestations i
Matar R, Oules B, Sohier P, et al. | J Eur Acad Dermatol Venereol
Aim: To analyze our experience in a French referral center and to perform a systematic review of the literature to evaluate the incidence and prognosis of cutaneous lesions observed in COVID?19 patients. 
CLINICAL CHARACTERISTICS
6/27/20
SARS-CoV-2 / COVID-19: Sys
Schnitzbauer AA, Kempf VAJ, Hack D, et al. | Surgeon
Aim: To summarize the evidence on standards for personal protective equipment (PPE) for the employees in the central emergency rooms and in the operating area as well as restructuring measures for the operations in the operating area in a COVID-plus area.
INFECTION CONTROL
6/27/20
Sinonasal pathophysiology
Gengler I, Wang JC, Speth MM, et al. | Laryngoscope Investig Otolaryngol
Aim: To synthesize existing scientific evidence on the role of sinonasal pathophysiology in COVID?19.
CLINICAL CHARACTERISTICS
6/26/20
Clinical Features and Outc
Meena J, Yadav J, Saini L, et al. | Indian Pediatr
Aim: To synthesize the information on clinical manifestations, laboratory findings, and outcome of COVID-19 among the pediatric population.
CLINICAL CHARACTERISTICS
6/26/20
Early responses of neurosu
Hanrahan JG, Burford C, Adegboyega G, et al. | World Neurosurg
Aim: To detail early experiences and changes to neurosurgical practice in response to the COVID-19 pandemic.
6/26/20
Immune-Inflammatory Parame
Feng X, Li S, Sun Q, et al. | Front Med
Aim: To explore the effect of risk factors on the severity of the disease, focusing on immune-inflammatory parameters, which represent the immune status of patients.
CLINICAL CHARACTERISTICS
6/26/20
Olfactory and taste disord
da Costa KVT, Carnauba ATL, Rocha KW, et al. | Braz J Otorhinolaryngol
Aim: To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19.
CLINICAL CHARACTERISTICS
6/26/20
RAPID RESPONSE: Corticoste
Helfand M | VA Evidence Synthesis Program
Aim: To review the evidence for using corticosteroids to treat acute respiratory distress syndrome in patients with COVID-19.
UPDATED
VA ESP
6/26/20
RAPID RESPONSE: COVID-19:
Duan-Porter W | VA Evidence Synthesis Program
Aim: To explore the length of stay in the intensive care unit (ICU) and time on invasive mechanical ventilation for adult patients with COVID-19.
UPDATED
VA ESP
6/25/20
Clinical features, Diagnos
Tahvildari A, Arbabi M, Farsi Y, et al. | Front Med
Aim: To characterize the clinical, diagnostic, and treatment characteristics of patients presenting with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/25/20
Considerations for Safe La
 | ECRI
Aim: To provide guidance on ways to protect staff, measures to limit transmission, recommendations for COVID-19 testing for pregnant women and for infants born to infected mothers, and optimal maternal care and breastfeeding recommendations.
6/25/20
Coronavirus Disease 2019 (
Saleem H, Rahman J, Aslam N, et al. | Cureus
Aim: To review the evidence on COVID-19 severity in children.
6/25/20
COVID-19 transmission risk
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of acquiring COVID-19 on an aircraft.
6/25/20
Infection outbreak in dayc
Pelland-St-Pierre L, Duquesne L | Center for Research in Public Health
Aim: To review the evidence on COVID-19 outbreaks in childcare centers and schools, including risk factors, symptoms, and attack rates.
6/25/20
Prevalence of comorbiditie
Espinosa OA, Dos Santos Zanetti A, Antunes EF, et al. | Rev Inst Med Trop Sao Paulo
Aim: To calculate the prevalence and geographical distribution of comorbidities in all patients admitted to intensive care units (ICUs), and the mortality rate of COVID-19.
6/25/20
What is the evidence to su
Qureshi Z, Jones N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify the evidence behind the 2-metre social distancing rule in the context of the still used large vs. small (droplet vs airborne) droplet size dichotomy in route of transmission.
UPDATED
6/24/20
A systematic review of pat
Polak SB, Van Gool IC, Cohen D, et al. | Mod Pathol
Aim: To increase our understanding of COVID-19 pathophysiology by constructing a timeline and correlating histopathological findings with clinical stages of COVID-19. 
CLINICAL CHARACTERISTICS
6/24/20
Clinical Presentation and
Matar R, Alrahamani L, Monzer N, et al. | Clin Infect Dis
Aim: To describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy.
CLINICAL CHARACTERISTICS
6/24/20
COVID-19 in Pregnant Women
Trippella G, Ciarcia M, Ferrari M, et al. | Pathogens
Aim: To provide a comprehensive overview of all the available data regarding clinical features, outcomes, and management of pregnant women with COVID-19. 
CLINICAL CHARACTERISTICS
6/24/20
Masks for Prevention of CO
Chou R, Dana T, Jungbauer R, et al. | Ann Intern Med
Aim: To examine the effectiveness of N95, surgical, and cloth masks in community and health care settings for preventing respiratory virus infections, and effects of reuse or extended use of N95 masks.
UPDATED
6/24/20
Neurologic Characteristics
Pinzon RT, Wijaya VO, Buana RB, et al. | Front Neurol
Aim: To understand the neurologic characteristic of the disease and help physicians with early diagnosis and management.
CLINICAL CHARACTERISTICS
6/24/20
Rapid systematic review of
Gordon M, Kagalwala T, Rezk K, et al. | BMJ Paediatr Open
Aim: To carry out a systematic review of the available studies on COVID-19 (coronavirus disease 2019) in neonates seen globally since the onset of the COVID-19 global pandemic in 2020.
6/24/20
Risk factors for 2019 nove
Xu L, Mao Y, Chen G, et al. | Aging
Aim: To systematically review evidence for the risk factors of COVID-19 patients progressing to critical illness.
6/24/20
The prevalence of symptoms
Grant MC, Geoghegan L, Arbyn M, et al. | PLoS One
Aim: To determine the prevalence of symptoms associated with COVID-19 worldwide.
CLINICAL CHARACTERISTICS
6/24/20
What Proportion of Healthc
Jones P, Roberts S, Hotu C, et al. | Emerg Med Australas
Aim: To determine the carriage of respiratory viruses on facemasks used by HCW.
6/23/20
A Systematic Review of Cas
Baksh M, Ravat V, Zaidi A, et al. | Cureus
Aim: To summarize the clinical presentation, laboratory and chest imaging findings, management protocols, and outcome of ARDS in COVID-19-positive patients.
CLINICAL CHARACTERISTICS
6/23/20
Application of Telemedicin
Gao Y, Liu R, Zhou Q, et al. | Ann Transl Med
Aim: To assess the effectiveness of telemedicine in reducing transmission of COVID-19 and reducing pressure on medical institutions.
UPDATED
6/23/20
Breastfeeding of Infants B
Yang N, Che S, Zhang J, et al. | Ann Transl Med
Aim: To conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding.
UPDATED
6/23/20
Cancer is associated with
Ofori-Asenso R, Ogundipe O, Agyeman AA, et al. | Ecancermedicalscience
Aim: To examine the prevalence of cancer and its association with disease severity in patients with novel coronavirus disease 2019 (COVID-19).
6/23/20
Chest Computed Tomography
Lv M, Wang M, Yang N, et al. | Ann Transl Med
Aim: To understand the role of CT for the diagnosis and the main imaging manifestations of patients with COVID-19.
UPDATED
DIAGNOSTICS
6/23/20
Clinical Characteristics o
Wang Z, Zhou Q, Wang C, et al. | Ann Transl Med
Aim: To review the clinical characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/23/20
Clinical features of sever
Huang D, Lian X, Song F, et al. | Ann Transl Med
Aim: To identify and treat the severe and critical patients with COVID-19 is the key clinical problem to be solved.
CLINICAL CHARACTERISTICS
6/23/20
COVID-19 and comorbidities
Gold MS, Sehayek D, Gabrielli S, et al. | Postgrad Med
Aim: To evaluate comorbidities associated with severe and fatal cases of COVID-19.
6/23/20
Effectiveness and Safety o
Lu S, Zhou Q, Huang L, et al. | Ann Transl Med
Aim: To review the evidence on the use of glucocorticoids in treating COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Effectiveness of Intraveno
Zhang J, Yang Y, Yang N, et al. | Ann Transl Med
Aim: To explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Efficacy and Safety of Ant
Wang J, Tang Y, Ma Y, et al. | Ann Transl Med
Aim: To evaluate the efficacy and safety of antibiotic agents in children with COVID-19, as well as to introduce the present situation of antibiotics use and bacterial coinfections in COVID-19 patients. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Laboratory Tests and Outco
Alnor A, Sandberg MB, Gils C, et al. | J Appl Lab Med
Aim: To examine which routine laboratory tests are associated with severe COVID-19 disease.
CLINICAL CHARACTERISTICS
6/23/20
Nosocomial Infections Amon
Zhou Q, Gao Y, Wang X, et al. | Ann Transl Med
Aim: To understand nosocomial infection in patients with COVID-19, SARS, and MERS.
UPDATED
6/23/20
Potential Effectiveness an
Shi Q, Zhou Q, Wang X, et al. | Ann Transl Med
Aim: To assess the potential effectiveness and safety of antiviral agents for COVID-19 in children. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Prevalence of Comorbiditie
Singh AK, Gillies CL, Singh R, et al. | Diabetes Obes Metab
Aim: To estimate the prevalence of both cardiometabolic and other co?morbidities in patients with COVID?19 infection, and to estimate the increased risk of severity and mortality in people with co?morbidities.
CLINICAL CHARACTERISTICS
6/23/20
Public health education fo
Li W, Liao J, Li Q, et al. | Ann Transl Med
Aim: To review the evidence on how health providers should advise families and parents to obtain health education information during the COVID-19 pandemic.
6/23/20
Rapid Review: What is the
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the effect of the COVID-19 pandemic on alcohol use and alcohol-related harms.
6/23/20
Update on the target struc
Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A, Kumar H, Bansal S, Medhi B | Indian J Pharmacol
Aim: To review the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective.
6/22/20
Impact of smoking status o
Karanasos A, Aznaouridis K, Latsios G, et al. | Nicotine Tob Res
Aim: To summarize relevant studies and quantify the impact of smoking on disease severity and mortality of hospitalized COVID-19 patients.
6/22/20
Inhaled corticosteroids: A
Armitage LC, Brettel R | Oxford COVID-19 Evidence Service Team
Aim: To review the current evidence on the use of inhaled corticosteroids to prevent the development of acute respiratory distress syndrome.
6/22/20
Olfactory and gustatory dy
Hoang MP, Kanjanaumporn J, Aeumjaturapat S, et al. | Asian Pac J Allergy Immunol
Aim: To review the associations of olfactory and gustatory dysfunctions with COVID-19 which will be useful for early diagnosis and self-isolation. 
CLINICAL CHARACTERISTICS
6/22/20
The psychological and ment
Luo M, Guo L, Yu M, et al. | Psychiatry Res
Aim: To assess the psychological and mental impact of COVID-19 among healthcare workers, the general population, and patients with higher COVID-19 risk.
6/21/20
Asymptomatic patients as a
Kronbichler A, Kresse D, Yoon S, et al. | Int J Infect Dis
Aim: To summarize the presentation of asymptomatic COVID-19 infections.
CLINICAL CHARACTERISTICS
6/21/20
Cardiac injury is associat
Parohan M, Yaghoubi S, Seraji A | Eur Heart J Acute Cardiovasc Care
Aim: To summarize available findings on the association between cardiac injury and severity of COVID-19 infection.
6/21/20
Hepatic manifestations and
Kunustor SK, Laukkanen JA | J Infect
Aim: To review the evidence on the characteristics and prevalence of hepatic manifestations and complications of COVID-19
6/21/20
Neurological Involvement o
Ghannam MG, Alshaer QA, Al-Chalabi MAC, et al. | J Neurol
Aim: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options.
UPDATED
6/21/20
Quinoxaline Derivatives as
Montana M, Montero V, Khoumeri O, et al. | Molecules
Aim: To compile and discuss recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives.
6/21/20
Systematic review of regis
Bienvenu A, Marty AM, Jones MK, et al. | One Health
Aim: To analyze studies registered on ClinicalTrials.gov that study hydroxycholorquine as a COVID-19 prophylaxis.
6/20/20
Antithrombotic therapies i
Maldonado E, Tao D, Mackey K | J Gen Intern Med
Aim: To synthesize evidence on thromboembolism incidence and outcomes with antithrombotic therapies in COVID-19.
UPDATED
VA ESP
CANDIDATE THERAPEUTICS
6/20/20
Asthma and COVID-19 in chi
Castro-Rodriguez JA, Forno E | Pediatr Pulmonol
Aim: To review the evidence on the role of asthma in children with COVID-19 and the risk of infection.
UPDATED
6/20/20
Coronavirus disease 2019 (
Shelmerdine S, Lovrenski J, Caro-Dominguez P, et al. | Pediatr Radiol
Aim: To systematically review available literature regarding imaging findings in paediatric cases of COVID-19.
CLINICAL CHARACTERISTICS
6/20/20
Novel Coronavirus Infectio
Raba AA, Abobaker A, Elgenaidi IS, et al. | Acta Pediatr
Aim: To evaluate the clinical characteristics of COVID?19 in neonates and children under one year of age.
CLINICAL CHARACTERISTICS
6/20/20
Patients With Specific Ski
Nobar NN, Goodarzi A | Dermatol Ther
Aim: To review the evidence on the course of COVID-19 in patients with dermatologic disorders, and the most effective management strategies.
6/20/20
Point-of-care lung ultraso
 | Health Technology, Wales
Aim: To reivew the evidence on the use of point-of-care ultrasound imaging for suspected and confirmed cases of COVID-19.
6/20/20
Prevalence and impact of a
Yang X, Jin Y, Li R, et al. | Crit Care
Aim: To assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prognosis of COVID-19 patients.
CLINICAL CHARACTERISTICS
6/20/20
Symptoms of COVID-19 among
Sacco G, Briere O, Asfar M, et al. | Geriatr Psychol Neurosychiatr Vieil
Aim: To identify, from international literature, the most common symptoms met in older adults infected with the SARS-CoV-2 virus.
CLINICAL CHARACTERISTICS
6/20/20
The Clinical Characteristi
Xuefeng M, Shouseng L, Chen L, Zhuang L, et al. | J Med Virol
Aim: To investigate the clinical features of pediatric inpatients with SARS-CoV-2 infection.
CLINICAL CHARACTERISTICS
6/20/20
The Limited Sensitivity of
Waller JV, Allen IE, Lin KK, et al. | Invest Radiol
Aim: To stratify studies as high or low risk of bias to determine the true sensitivity of CT for severe acute respiratory syndrome coronavirus-2 infection
6/20/20
Variation in Ventilator Al
Piscitello GM, Kapania EM, Miller WD, et al. | JAMA Netw Open
Aim: To evaluate the number of publicly available US state guidelines for ventilator allocation and the variation in state recommendations for how ventilator allocation decisions should occur and to assess whether unique criteria exist for pediatric patients.
6/19/20
Efficacy of cloth face mas
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the efficacy of cloth face masks in helping to prevent the spread of COVID-19.
UPDATED
6/19/20
Extended use or reuse of p
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the extended use or re-use of personal protective equipment (PPE) during COVID-19.
6/19/20
Management of COVID-19-Pos
Prato AP, Conforti A, Almstrom M, et al. | Front Pediatr
Aim: To propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature.
6/19/20
Systematic Review of Clini
Lakhani HV, Pillai SS, Zehra M, et al. | Int J Environ Res Public Health
Aim: To provide insight on the pathogenesis and the transmission dynamics of CoVID-19 along with pharmacological and non-pharmacological intervention strategies to mitigate the clinical manifestation of this virus.
6/19/20
The impact of COVID-19 on
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the impact of COVID-19 on the mode and content of clinical education and current recommendations to address the impact.
6/19/20
The Implication of Ocular
Latalska M, Mackiewicz J | Ann Agric Environ Med
Aim: To review the evidence of ocular pathologies in asymptomatic COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Hydrotherapy and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the safe use of pools for hydrotherapy or aquatic physiotherapy during COVID-19.
6/18/20
Incidence of acute kidney
Chen Y, Shao S, Hsu C, et al. | Crit Care
Aim: To quantify the incidence of acute kidney injury in COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
International Public Healt
Tabari P, Amini M, Moghadami M, et al. | Iran J Med Sci
Aim: To determine countries’ public responses to the epidemic of COVID-19 and how they developed administrative approaches towards the outbreak.
UPDATED
6/18/20
Olfactory Dysfunction in C
Chung TW, Sridhar S, Zhang AZ, et al. | Open Forum Infect Dis
Aim: To review the evidence on olfactory disturbances in COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Telehealth in Urology: A S
Novara G, Checcucci E, Crestani A, et al. | Eur Urol
Aim: To perform a systematic review of the literature and evaluate all the available studies on urological applications of telehealth.
6/17/20
A Systematic Review and Me
Grover A, Oberoi M | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the continued use of angiotensin converting enzyme inhibitors (ACEI) and angtiotensin receptor blockers (ARBs) in patients with COVID-19.
UPDATED
6/17/20
COVID 19 therapies and ant
Di Lorenzo G, Di Trolio R, Kozlakidis Z, et al. | Crit Rev Oncol Hematol
Aim: To review the evidence on the clinical outcomes of COVID-19-positive patients and the possible interactions between drugs used in experimental therapy of COVID-19 and commonly used antineoplastic drugs.
CANDIDATE THERAPEUTICS
6/17/20
High-flow nasal cannula fo
Agarwal A, Basmaji J, Muttalib F, et al. | Can J Anaesth
Aim: To describe the efficacy and safety of HFNC in acute hypoxemic respiratory failure; and to determine the risk of dispersion, aerosol generation and associated transmission of COVID-19 with HFNC.
UPDATED
WHO COLLABORATIVE
6/17/20
Rapid Review: Safety and E
Sharpe H | Alberta Health Services
Aim: To review the evidence on the safety and efficacy of video laryngoscopy in intubating patients with suspected or confirmed COVID-19.
6/17/20
Severe Coronavirus Infecti
Galang RR, Chang K, Strid P, et al. | Obstet Gynecol
Aim: To summarize the clinical presentation, course of illness, and pregnancy and neonatal outcomes in pregnant women with MERS-CoV, SARS-CoV, or SARS-CoV-2.
6/17/20
Social and economic vulner
Lauvrak V, Juvet L | Norwegian Institute of Public Health
Aim: To identify any reported associations between increased severity of COVID-19 disease, and infection rates in populations postulated to be socially or economic vulnerable.
6/15/20
Ongoing Trials of Plasma-B
Raymond C, Loshak H | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating IVIg and hyperimmune globulin to treat COVID-19.
6/15/20
Risk of Virus Contaminatio
Pavan N, Crestani A, Abrate A, et al. | Eur Urol Focus
Aim: To evaluate the risk of virus spread due to surgical smoke during surgical procedures.
6/15/20
Stress factors in nursing
Barbosa DJ, Gomes MP, Souza BA, et al. | Comun. ciênc. saúde
Aim: To identify the main psychological effects of the COVID-19 pandemic on nursing professionals; describe the main factors capable of generating psychological stress in nursing professionals, describe the coping strategies to combat emotional stress.
6/14/20
A Systematic Review on Gui
Heldwein FL, Loeb S, Wroclawski ML, et al. | Eur Urol Focus
Aim: To summarize guidelines and recommendations on the urology standard of care during the COVID-19 pandemic.
6/14/20
COVID-19 and gastrointesti
Velev V, Popov M, Velikov P, et al. | Infez Med
Aim: To describe the incidence and type of the gastrointestinal injury (GI) in COVID-19, as well as their prognostic value.
CLINICAL CHARACTERISTICS
6/14/20
Ivermectin: a systematic r
Heidary F, Gharebaghi R | J Antibiot (Tokyo)
Aim: To summarize the antiviral effects of ivermectin by reviewing available in vivo and in vitro studies over the past 50 years.
CANDIDATE THERAPEUTICS
6/14/20
MERS-CoV and SARS-CoV Infe
Bonilla-Aldana DK, Cardona-Trujillo MC, García-Barco A, et al. | Infez Med
Aim: To review the evidence on the role of animals as potential reservoirs for MERS-CoV and SARS-CoV.
UPDATED
6/14/20
Risk of hepatic failure in
Samidoust P, Samidoust A, Samadani AA, et al. | Infez Med
Aim: To investigate the incidence of liver injury among published literature from 2019-Jan-01 to 2020-April-03 to provide an outline for further studies on the liver injury of COVID-19. 
6/14/20
Value of leukocytosis and
Yamada T, Wakabayashi M, Yamaji T, et al. | Clin Chim Acta
Aim: To investigate the association between severe COVID-19 and a change in white blood cell (WBC) count, an elevation of C-reactive protein (CRP), and fever, and to evaluate the diagnostic accuracy of leukocytosis and an elevation of CRP.
CLINICAL CHARACTERISTICS
6/13/20
Abnormal Liver Function Te
Xin S, Xu J, Yu Y | J Gastrointestin Dis
Aim: To compare the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis.
CLINICAL CHARACTERISTICS
6/13/20
Clinical manifestations an
Wang L, Shen Y, Li M, et al. | J Neurol
Aim: To systematically collect and investigate the clinical manifestations and evidence of neurological involvement in COVID-19.
CLINICAL CHARACTERISTICS
6/13/20
Effect of Convalescent Pla
Zhu T, Xu A, Bai X, et al. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Aim: To systematically review evidence for the effect of convalescent plasma and immunoglobulin on treatment of severe acute respiratory syndrome (SARS), and further provide advice on the treatment of coronavirus disease 2019 (COVID-19).
CANDIDATE THERAPEUTICS
6/13/20
Maternal transmission of S
Walker KF, O'Donoghue K, Grace N, et al. | BJOG
Aim: To estimate the risk of the neonate becoming infected with SARS-COV-2 by mode of delivery, type of infant feeding and mother-infant interaction. 
6/13/20
Pediatric COVID-19: System
Patel NA | Am J Otolaryngol
Aim: To elucidate a better understanding of the global impact of COVID-19 on the pediatric population.
6/12/20
Does coronavirus affect th
Almufarrij I, Uus K, Munro KJ | Int J Audiol
Aim: To investigate audio-vestibular symptoms associated with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
6/12/20
Evidence brief on the risk
 | Public Health Agency of Canada
Aim: To review the evidence on characteristics of the workplace that can increase the risk of COVID-19 transmission.
6/12/20
Prevalence of Gastrointest
Parasa S, Desai M, Chandrasekar VT, et al. | JAMA Netw Open
Aim: To provide a pooled estimate of GI symptoms, liver enzyme levels outside reference ranges, and fecal tests positive for SARS-CoV-2 among patients with COVID-19.
CLINICAL CHARACTERISTICS
6/12/20
Rapid Review: Effectivenes
Erdmann R | Alberta Health Services
Aim: To review the evidence on the effectivness of workplace screening programs for reducing the spread of COVID-19 in healthcare settings.
6/12/20
Rapid Review: What is know
 | National Collaborating Centre for Methods and Tools
Aim: To identify, appraise, and summarize emerging research evidence on the efficacy and cost-effectiveness of copper materials to reduce transmission of the virus.
6/12/20
Rapid Review: What is the
 | National Collaborating Centre for Methods and Tools
Aim: To identify, appraise, and summarize emerging research evidence on the effectiveness of cohorting virus-positive residents to shared rooms in care facilities.
6/12/20
Systematic review of inter
Chiesa-Estomba CM, Lechien JR, Calvo-Henriquez C, et al. | Oral Oncol
Aim: To summarize in a systematic way the available recommendations from 18 guidelines from all over the world.
UPDATED
6/12/20
XPEL® RX Silver Ion Protec
 | Malaysian Health Technology Assessment Section
Aim: To provide scientific evidence on the use of XPEL® RX silver ion protection film for COVID-19 based on a request from the Medical Care Quality Section (MOH) following a proposal from a company to introduce the technology.
6/11/20
Evidence brief of aerosol
 | Public Health Agency of Canada
Aim: To review the evidence on SARS-CoV-2 transmission in dental settings, and the infection transmission risk from aerosol generating procedures use in dental care?
6/11/20
Venous Thromboembolism Pro
Bresee L, MacDougall D | CADTH
Aim: To describe the epidemiology of venous thromboembolism (VTE), review the evidence on the use of pharmacologic thromboprophylaxis for the prevention of VTE, and list ongoing trials.
6/10/20
Community health workers f
Bhaumik S, Moola S, Tyagi J, et al. | BMJ Glob Health
Aim: To examine the evidence to inform the potential role, enablers and barriers for community health workers during COVID-19 prevention and control from the National Health Systems Resource Centre (NHSRC), India.
6/10/20
Optimal Timing for Perform
 | ECRI
Aim: To review the evidence on the optimal timing for performing tracheotomy in patients with acute respiratory failure.
6/10/20
Should individuals in the
Iversen BG, Vestrheim DF, Flottorp S, et al. | Norwegian Institute of Public Health
Aim: To review the evidence on the use of face masks by people in the community to reduce the spread of COVID-19.
6/10/20
Transmission of COVID-19 b
Pelland-St-Pierre L, Cortes JB | Center for Research in Public Health
Aim: To review the evidence on the impact of contact time, distance between contacts, and the environment on the probablity of transmission of the coronavirus between humans.
6/9/20
A rapid systematic review
MacIntyre CR, Chughtai AA | Int J Nurs Stud
Aim: To review the evidence around the efficacy of masks and respirators for healthcare workers, sick patients and the general public.
INFECTION CONTROL
6/9/20
A systematic review of imm
Razmi M, Madjd Z, Ghods R, et al | PROSPERO
6/9/20
CT Manifestations and Clin
Wan S, Li M, Ye Z, et al. | Acad Radiol
Aim: To assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19).
CLINICAL CHARACTERISTICS
6/9/20
Does Adding of Hydroxychlo
Patel TK, Barvaliya M, Kevadiya BD, et al. | J Neuroimmune Pharmacol
Aim: To find out early trends of mortality in COVID-19 patients treated with hydroxychloroquine based on published literature.
CANDIDATE THERAPEUTICS
6/9/20
Preparing medical students
Ashcroft J, Byrne MHV, Brennan PA, et al. | Postgrad Med J
Aim: To identify pandemic and disaster medicine-themed training programmes aimed at medical students and to assess whether these interventions had an effect on objective measures of disaster preparedness and clinical outcomes.
6/9/20
Rates of Maternal and Peri
Huntley BJF, Huntley ES, Di Mascio D, et al. | Obstet Gynecol
Aim: To ascertain the frequency of maternal and neonatal complications, as well as maternal disease severity, in pregnancies affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
UPDATED
6/9/20
Use of Remdesivir in the M
Nasir M, Talha KA, Islam T, et al. | Mymensingh Med J
Aim:  To evaluate the available evidence on efficacy, safety to identify any promising role for compassionate use of remdesivir in patient suffered for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as re-purposeful use. 
CANDIDATE THERAPEUTICS
6/8/20
Are there risk factors and
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: To determine if there are any known risk factors for ARDS in this infection and whether there are any interventions to prevent ARDS developing.
6/8/20
Risk factors for mortality
Parohan M, Yaghoubi S, Seraj A, et al. | Aging Male
Aim: To summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection.
UPDATED
6/8/20
The potential of drug repo
Lima WG, Brito J, Overhage J, et al. | Arch Virol
Aim: To describe the drug repositioning strategy against SARS-CoV-2 and to discuss the clinical impact of this approach in the current pandemic context. 
CANDIDATE THERAPEUTICS
6/8/20
The use of voluntary smart
Williams S | Newfoundland and Laborador Centre for Applied Health Research
6/7/20
Cardiovascular complicatio
Kunutsor S, Laukkanen | J Infect
Aim: To review the evidence on cardiovascular complications associated with COVID-19.
UPDATED
6/7/20
Medical and Surgical Educa
Dedeilia A, Sotiropoulos MG, Hanrahan JG, et al. | In Vivo
Aim: To identify the challenges imposed on medical and surgical education by the COVID-19 pandemic, and the proposed innovations enabling the continuation of medical student and resident training. 
6/7/20
Rapid Systematic Review: T
Loades ME, Chatburn E, Higson-Sweeney N, et al. | J Am Acad Child Adolesc Psychiatry
Aim: To establish what is known about how loneliness and disease containment measures impact on the mental health in children and adolescents.
6/6/20
A systematic review of neu
Romoli M, Jelcic I, Bernard-Valnet R, et al. | Eur J Neurol
Aim: To  review available evidence for reports of neurological signs and symptoms in Coronavirus disease (COVID)-19 patients to identify cases with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or immune-mediated reaction in the nervous system.
CLINICAL CHARACTERISTICS
6/6/20
Estimate of the Basic Repr
Alimohamadi Y, Taghdir M, Sepandi M | J Prev Med Public Health
Aim: To estimate the pooled R0 for COVID-19 in the current outbreak.
6/6/20
Frequency of Abnormalities
Mohamed MFH, A-Shokri S, Yousaf Z, et al. | Am J Trop Med Hyg
Aim: To pool the proportion of various reported lung abnormalities detected by LUS in symptomatic COVID-19 patients. 
CLINICAL CHARACTERISTICS
6/6/20
Mortality rates of patient
Quah P, Li A, Phua J | Crit Care
Aim: To review the outcomes of ICU patients with COVID-19 from the existing literature.
6/5/20
Comparison of Confirmed CO
Pormohammad A, Ghorbani S, Baradaran B, et al. | Rev Med Virol
Aim: To review the evidence on clinical and laboratory characteristics of COVID-19 infected patients.
UPDATED
CLINICAL CHARACTERISTICS
6/5/20
Effectiveness of preventiv
Lahiri A, Jha SS, Bhattacharya S, et al. | Indian J Public Health
Aim: To understand the effectiveness of NPIs reported in the contemporary literatures describing prediction models for prevention of the ongoing pandemic of SARS-CoV-2 specifically in Indian population.
6/5/20
Extended use or re-use of
Toomey E, Conway Y, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the extended use or re-use of single-use respirators and surgical masks by frontline healthcare workers.
6/5/20
Facemasks for prevention o
Aggarwal N, Dwarakanathan V, Gautam N, et al. | Indian J Public Health
Aim: To estimate the effectiveness of facemask use alone or along with hand hygiene in community settings in reducing the transmission of viral respiratory illness.
INFECTION CONTROL
6/5/20
Nosocomial COVID-19 infect
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the transmission of COVID-19 to and from healthcare professionals and strategies to reduce risk of nosocomial infections of COVID-19.
6/5/20
Rapid Review: Risk of Tran
Leal J | Alberta Health Services
Aim: To review the evidence on the transmission of SARS-CoV-2 virus through heating, ventiliation, and air conditioning (HVAC) systems in hospitals or non-hospital settings.
6/5/20
Reopening Personal Service
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the approaches being taken to mitigate the risks associated with reopening establishments that provide personal services.
6/5/20
Vaccines and Drug Therapeu
Bhagavathula AS, Aldhaleei WA, Rovetta A, et al. | Cureus
Aim: To extract and summarize information on potential vaccines and therapeutic agents against COVID-19 at different stages of clinical trials from January to March 2020.
CANDIDATE THERAPEUTICS
6/5/20
Workforce reconfiguration
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence regarding temporary workforce reconfigurations such as splitting of teams and establishing social distancing protocols within teams to minimise staff exposure to COVID-19.
UPDATED
6/4/20
A new conceptual model of
Rosenwohl-Mack A, Schumacher K, Fang ML, et al. | Int J Nurs Stud
Aim: To synthesize the evidence on experiences of aging in place in the United States.
6/4/20
Computed tomography use du
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of computed tomography in patients with COVID-19.
6/4/20
Considerations for Safe La
 | ECRI
Aim: Guidance on ways to protect staff, measures to limit transmission, recommendations for COVID-19 testing for pregnant women and for infants born to infected mothers, and optimal maternal care and breastfeeding recommendations.
6/4/20
COVID-19 infectivity and t
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the infection rate, infectivity and transmission of COVID-19 in children?
6/4/20
Efficacy and safety of cor
Ye Z, Wang Y, Colunga-Lozano LE, et al. | CMAJ
Aim: To examine the impact of corticosteroids in COVID-19 and related severe acute respiratory illnesses to support a guideline for managing COVID-19.
CANDIDATE THERAPEUTICS
6/4/20
Estimating the extent of a
Byambasuren O, Cardona M, Bell K, et al. | medRxiv
Aim: To synthesize all available research on the asymptomatic rates and transmission rates where possible. 
6/4/20
Hypertension is associated
Pranata R, Lim MA, Huang I, et al. | J Renin Angiotensin Aldosterone Syst
Aim: To investigate the association between hypertension and outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
6/4/20
Impact of Cerebrovascular
Pranata R, Huang I, Lim MA, et al. | J Stroke Cerebrovasc Dis
Aim: To evaluate the latest evidence on the association between cerebrovascular, cardiovascular disease, and poor outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
6/4/20
Improving the quality of c
Abdollahpour S, Khadivzadeh T | J Matern Fetal Neonatal Med
Aim: To improve the quality of care by health providers through what they need to know about coronavirus during pregnancy and childbirth.
6/4/20
Maternal and neonatal outc
Smith V, Deo D, Warty R, et al. | PLoS One
Aim: To systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19.
6/4/20
Prolonged fecal shedding o
Santos VS, Gurgel RQ, Cuevas LE, et al. | J Pediatr Gastroenterol Nutr
Aim: To investigate differences in viral shedding in respiratory and fecal samples from children with COVID-19.
6/4/20
Risk Factors of Severe Dis
Zhang JJY, Lee KS, Ang LW, et al. | Clin Infect Dis
Aim: To review the evidence on predictors of severe disease and the efficacy of different treatments for COVID-19.
6/4/20
Safety of personal protect
 | Health Technology, Wales
Aim: To review the evidence on the safety of personal protective equipment gowns for health and social care workers.
6/4/20
The role and response of p
Mitchell S, Maynard V, Lyons V, et al | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the role and reponse of primary care and community nursing services in the delivery of palliative care in epidemics and pandemics.
6/3/20
Characteristics of registe
Yang M, Shang Y, Tian Z, et al. | Integr Med Res
Aim: To review the study characteristics of registered clinical trials on COVID-19 and provide guidance for future trials to avoid duplicated effort.
6/3/20
COVID-19 in Solid Organ Tr
Nacif LS, Zanini LY, Waisberg DR, et al. | Clinics (Sao Paulo)
Aim: To collate available data on COVID-19 infection in solid organ transplantation (SOT) patients.
6/3/20
COVID-19 pandemic and ment
Vindegaard N, Benros ME | Brain Behav Immun
Aim: To systematically review the literature in order to provide an overview of the psychiatric complications to COVID-19 infection (direct effect) and how COVID-19 are currently affecting mental health among psychiatric patients and general public (indirect effect) alongside with factors altering the risk of psychiatric symptoms in both groups.
6/3/20
Efficacy and safety of ant
Liu W, Zhou P, Chen K, et al. | CMAJ
Aim: To support the development of a COVID-19 management guideline by reviewing evidence that addressed the benefits and harms of 7 antiviral treatments for COVID-19.
CANDIDATE THERAPEUTICS
6/3/20
Lymphopenia in severe coro
Huang I, Pranata R | J Intensive Care
Aim: To investigate the association of lymphocyte count on admission and the severity of COVID-19.
CLINICAL CHARACTERISTICS
6/3/20
Mitigating negative conseq
 | INESSS Quebec
6/3/20
Should healthcare personne
Vestrheim DF, Iversen BG, Flottorp S, et al. | Norwegian Institute of Public Health
Aim: To review the evidence on the use of facemasks by asymptomatic personnel in long-term care facilities for primary prevention of COVID-19 infection.
6/3/20
Systematic review and crit
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
UPDATED
6/3/20
The need of health policy
Iannone P, Castellini G, Coclite D, et al. | PLoS One
Aim: To assess the efficacy of N95 respirators versus surgical masks for the prevention of respiratory tract infections transmission among HCWs.
UPDATED
6/2/20
Mast cell stabilisers, leu
Raymond M, Ching-A-Sue G, Van Hecke O | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on mast cell stabilizers, leukotriene antagonists, and antihistimines in COVID-19.
UPDATED
6/2/20
The association between se
Liu M, Gao Y, Zhang Y, et al. | J Infect
Aim: To review the evidence on the assocation between severe or death COVID-19 and autoimmune disease.
6/1/20
Aerosol generating procedu
Bolton L, Mills C, Wallace S, et al. | Int J Lang Commun Disord
Aim: To review the evidence underpinning the current healthcare policies in relation to AGPs, dysphagia assessment, and risk of transmission of and infection with COVID?19 in response to urgent clinical information needs.
6/1/20
Children's heart and COVID
Sanna G, Serrau G, Bassareo PP, et al. | Eur J Pediatr
Aim: To summarize all COVID-19 cases with a cardiac involvement published in paediatric age and explain the underlying mechanisms responsible for COVID-19-related myocardial damage.
6/1/20
Contributions of dermatolo
Wang Y, Fang R, Zhang H, et al. | Dermatol Ther
Aim: To reveal the contribution of dermatologists in COVID-19 research.
6/1/20
CT in coronavirus disease
Ojha V, Mani A, Pandey NN, et al. | Eur Radiol
Aim: To evaluate the key imaging manifestations of COVID-19 on chest CT in adult patients by providing a comprehensive review of the published literature.
CLINICAL CHARACTERISTICS
6/1/20
Drinking no-links to the s
Liu M, Gao Y, Shi S, et al  | J Infect
Aim: To quantitatively assess whether drinking is associated with the severity of COVID-19.
6/1/20
Markers of liver injury an
Kunutsor S, Laukkanen J | J Infect
Aim: To review the evidence on clinical characteristics and outcomes of liver injury in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
6/1/20
Physical distancing, face
Chu DK, Akl EA, Duda S, et al. | Lancet
Aim: To investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.
UPDATED
6/1/20
Systematic Review and Meta
Adams HJA, Kwee TC, Yakar D, et al. | AJR Am J Roentgenol
Aim: To systematically review and meta-analyze the diagnostic accuracy of chest CT in detecting coronavirus disease (COVID-19).
DIAGNOSTICS
5/31/20
Co-infections in people wi
Lansbury L, Lim WS, Baskaran V, et al. | J Infect
Aim: To evaluate the burden of co-infections in patients with COVID-19.
UPDATED
5/29/20
Cell-based therapy to redu
Qu W, Wang Z, Hare JM, et al. | Stem Cells Transl Med
Aim: To review the available literature on safety, efficacy, and cytokine responses to MSC therapies in patients with ARDS.
5/29/20
Impact of cardiovascular d
Li X, Guan B, Su T, et al. | Heart
Aim: To assess the impact of underlying cardiovascular comorbidities and acute cardiac injury on in-hospital mortality risk.
5/29/20
Interventions to promote c
 | INESSS Quebec
5/28/20
An Updated Systematic Revi
Das S, Bhowmick S, Tiwari S, et al. | Clin Drug Investig
Aim: To systematically review the therapeutic role of HCQ in COVID-19 from the available literature.
CANDIDATE THERAPEUTICS
5/28/20
Asthma and COVID-19: risks
Hartmann-Boyce J, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the risk and management of people of asthma during the COVID-19 pandemic.
5/28/20
Can video consultations re
Sutherland AE, Stickland J, Wee B | BMJ Support Palliat Care
Aim: To identify the highest currently available level of evidence to inform this major change in clinical practice.
5/28/20
COVID-19 Standards and Pra
Williams S, Walsh C | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the standards and practices that non-medical first responders should use in all activities with potential for exposure to high risk populations.
5/28/20
Diabetes care during COVID
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on risk stratification approaches to identify risk level in diabetes patients and clinical pathways to support diabetes management and service delivery.
UPDATED
5/28/20
Domestic and family violen
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of domestic and family violence during the COVID-19 pandemic.
UPDATED
5/28/20
Fibrinolysis and PCI for S
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on fibrinolysis versus primary percutaneous coronary intervention in the treatment of ST-Elevation Myocardial Infarction (STEMI).
UPDATED
5/28/20
Guidance and underlying ev
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence and guidelines on the use of PPE in COVID-19.
5/28/20
Inpatient management of CO
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on inpatient management of COVID-19.
UPDATED
5/28/20
Intubation in the emergenc
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on safe practice of intubation in the emergency department during the COVID-19 pandemic.
UPDATED
5/28/20
Large vessel occlusion str
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on large vessel occlusion stroke in patients with COVID-19.
5/28/20
Neonates and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of newborn babies developing COVID-19.
UPDATED
5/28/20
NIPPV and requirements
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how the increasing use of NIPPV to manage suspected or confirmed COVID-19 patients led to any additional guidance regarding the physical requirements and engineering services.
UPDATED
5/28/20
Novelty in the gut: a syst
Kumar VCS, Mukherjee S, Harne PS, et al. | BMJ Open Gastroenterol
Aim: To perform a systematic review and meta-analysis on the GI symptoms of COVID-19.
CLINICAL CHARACTERISTICS
5/28/20
Preserving consumer and pa
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preservingc onsumer and patient partnership approaches during COVID-19.
5/28/20
Pulmonary rehabilitation a
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance for the provision of pulmonary rehabilitation for people recovering from COVID-19.
UPDATED
5/28/20
Reducing adverse impacts o
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on supporting health systems to reduce adverse impacts on people with a lived experience of mental health issues during the COVID-19 pandemic.
5/28/20
Rehabilitation needs of po
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the rehabilitation needs of post-acute COVID-19 patients and the appropriate timing of rehabilitation interventions.
UPDATED
5/28/20
Renal replacement therapie
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of renal replacement therapies in intensive care units for patients with COVID-19?
5/28/20
Sanitising and covering la
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of santising and covering large medical equipment for COVID-19.
5/28/20
Scope, quality, and inclus
Dagens A, Sigfrid L, Cai E, et al. | BMJ
Aim: To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.
UPDATED
5/28/20
Spirometry and transmissio
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on spirometry and whether it's an aerosol generating procedure, and the risk this procedure carries during the COVID-19 pandemic.
UPDATED
5/28/20
Symptom burden and clinica
Keeley P, Buchanan D, Carolan C, et al. | BMJ Palliat Care
Aim: To review the evidence on symptom prevalence and intensity, resistance or susceptibility to symptom control, and mode of death in COVID-19 patients to inform palliative and end-of-life care.
CLINICAL CHARACTERISTICS
5/28/20
Temporary shared accommoda
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on temporary shared accomodations, particularly for people experiencing homelessness.
UPDATED
5/28/20
The vaccine journey for CO
Checcucci E, Piramide F, Pecoraro A, et al. | Panminerva Med
Aim: To summarize the preliminary experiences and ongoing clinical trials of the major candidates and challenges of the vaccine strategies in humans.
5/28/20
Thermal imaging for detect
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of mass thermal imaging in identifying people with COVID-19.
UPDATED
5/28/20
Transmission of respirator
Zhen J, Chan C, Schoonees A, et al. | South African Med J
Aim: To assess the abilities of different interventions to decrease the incidence of droplet-based infections among people using public ground transport.
5/28/20
Validated tools to diagnos
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on which tools are validated to diagnose respiratory illness via telehealth.
UPDATED
5/28/20
Ventilation use for COVID-
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the proportion of COVID-19 cases in intensive care units that require ventilation.
UPDATED
5/28/20
Virtual care and telehealt
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effective use of telemedicine or virtual care in different clinical areas.
5/27/20
A systematic review on COV
Chan VW, Chiu PK, Yee CH, et al. | World J Urol
Aim: To review the evidence on COVID-19 and its potential urological manifestations.
CLINICAL CHARACTERISTICS
5/27/20
COVID-19 and newborn healt
Duran P, Berman S, Niermeyer S, et al. | Rev Panam Salud Publica
Aim: To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2.
5/27/20
Hydroxychloroquine or Chlo
Hernandez AV, Roman YM, Pasupuleti V, et al. | Ann Intern Med
Aim: To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19).
CANDIDATE THERAPEUTICS
5/27/20
Impacts on workers and peo
Bergeron-Longpre M, Bertrand-Deschenes A | Center for Research in Public Health
Aim: To review the evidence on the impact of the pandemic on people and workers bereaved or confronted with death.
5/27/20
International Guidelines A
Moletta L, Peirobon ES, Capovilla G, et al. | Int J Surg
Aim: To review the available recommendations published by general Surgery Societies and Health Institutions and evaluate the underlying Literature.
5/27/20
Non-steroidal anti-inflamm
Yousefifard M, Zali A, Zarghi A, et al. | Int J Clin Pract
Aim: To evaluate the efficacy and safety of various NSAIDs in viral respiratory infections so that we can reach a conclusion on which NSAID is best choice for COVID-19.
CLINICAL CHARACTERISTICS
5/27/20
Predictive Symptoms and Co
Jain V, Yuan JM  | Int J Public Health
Aim: To identify specific symptoms and comorbidities predicting severe COVID-19 and intensive care unit (ICU) admission.
UPDATED
5/27/20
Role of biological Data Mi
Albahri AS, Hamid RA, Alwan JK, et al. | J Med Syst
Aim: To obtain an overview of this critical virus, address the limitations of utilising data mining and ML algorithms, and provide the health sector with the benefits of this technique. 
5/27/20
Treatments administered to
Fajgenbaum DC, Khor JS, Gorzewski A, et al. | Infect Dis Ther
Aim: To systematically evaluate the treatments adminstered to COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/27/20
What explains the high rat
Durand-Moreau Q, Adisesh A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the transmission of SARS-CoV-2 in meat and poultry facilities.
5/26/20
Clinical evidence for repu
Rodrigo C, Fernando SD, Rajapakse S | Clin Microbiol Infect
Aim: To summarize evidence from human clinical studies for using HCQ or CQ as antiviral agents for any viral infection.
CANDIDATE THERAPEUTICS
5/26/20
The role of nicotine in CO
Hartmann-Boyce J, Lindson N | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the role of nicotine in COVID-19.
5/25/20
Assessment and management
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the assessment and management of suspected or confirmed COVID-19 patients presenting to the Emergency Department (ED).
5/25/20
Homelessness and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance to support health systems response to COVID-19 and associated risks for people experiencing homelessness.
5/25/20
Long-term clinical outcome
Ahmed H, Patel K, Greenwood D, et al. | J Rehabil Med
Aim: To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission.
5/24/20
Point-of-Care Diagnostic T
Ricco M, Ferraro P, Gualerzi G, et al. | J Clin Med
Aim: To explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak.
DIAGNOSTICS
5/23/20
COVID-19 and Liver Dysfunc
Youssef M, Hussein M, Attia AS, et al. | J Med Virol
Aim: To find the association between liver injuries and the severity of COVID?19 disease.
5/23/20
Herbal Medicine for the Tr
Ang L, Song E, Lee HW, et al. | J Clin Med
Aim: To evaluate the effectiveness and adverse events of herbal medicines for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
5/23/20
Laboratory findings of COV
Zhang Z, Hou Y, Li D, et al. | Scand J Clin Lab Invest
Aim: To assess laboratory findings in patients with COVID-19.
CLINICAL CHARACTERISTICS
5/22/20
Efficacy and safety of con
Devasenapathy N, Ye Z, Loeb M, et al. | CMAJ
Aim: To review the safety and efficacy of convalescent plasma in severe coronavirus disease 2019 (COVID-19) patients for guideline development
CANDIDATE THERAPEUTICS
5/22/20
Elevated N-terminal pro-br
Pranata R, Huang I, Lukito AA, et al. | Postgrad Med J
Aim: To assess the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and mortality in patients with COVID-19.
CLINICAL CHARACTERISTICS
5/22/20
Predictors of mortality in
Tian W, Jiang W, Yao J, et al. | J Med Virol
Aim: To evaluate the risk factors associated with mortality in COVID?19.
5/22/20
Rapid Review: Singing as a
Kania-Richmond A, Sharpe H | Alberta Health Services
Aim: To review the evidence on the risk of transmission of COVID-19 via singing for aysmptomatic/presymptomatic and symptomatic people with COVID-19.
5/21/20
Children are unlikely to b
Ludvigsson JF | Acta Paediatr
Aim: To review the evidence on the role of children in the transmission of SARS-CoV-2.
5/21/20
Clinical Outcomes in COVID
Antwi-Amoabeng D, Kanji Z, Ford B, et al. | J Med Virol
Aim: To summarize the baseline characteristics of COVID-19 patients who received tocilizumab in order to identify nuanced predictors of response to therapy and other clinical outcomes.
CANDIDATE THERAPEUTICS
5/21/20
LIVING RAPID REVIEW: Risk
Goldstein KM, Ghadimi K, Mystakelis H, et al. | VA Evidence Synthesis Program
Aim: To review the evidence on the risk of transmitting SARS-CoV-2, SARS, MERS, and influenza with administration of drugs via nebulizer
VA ESP
5/21/20
Reopening Schools: Mitigat
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the approaches being taken to migitate the risks associated with reopening schools.
5/21/20
Video calls for reducing s
Noone C, McSharry J, Smalle M, et al. | Cochrane Database Syst Rev
Aim: To assess the effectiveness of video calls for reducing social isolation and loneliness in older adults. 
5/20/20
Age and vulnerability (ACE
Salem JB | Center for Research in Public Health
Aim: To review the evidence on the expression of the angiotensin 2 converting enzyme (ACE2) in children and adults.
5/20/20
Coronavirus Disease 2019 (
Aiello F, Afflitto GG, Mancino R, et al. | Eye
Aim: To review the evidence on the presence of SARS-CoV-2 in cornea, conjunctiva, lacrimal sac, and tears in patients with COVID-19.
5/20/20
COVID-19 and risk factors
Flodgren GM, Vestrheim DF, Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the risk factors for severe COVID-19 disease.
5/20/20
Re-opening child-related f
Park M | Vancouver Coastal Health
Aim: To review the evidence on re-opening child-related facilities and gatherings.
5/20/20
SARS-COV-2 infection in ch
Liguoro I, Pilotto C, Bonanni M, et al. | Eur J Pediatr
Aim: To systematically review main clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric age.
CLINICAL CHARACTERISTICS
5/20/20
Surgical Practice in the C
Hojaij FC, chinelatto LA, Book GHP, et al. | Clinics
Aim: To analyze different perspectives concerning the COVID-19 pandemic, aiming to provide recommendations that could guide surgeons and entities toward screening, elective and emergency surgeries, decision making, and operating room management. 
5/19/20
COVID-19 pneumonia and pre
Kasraeian M, Zare M, Vafaei H, et al. | J Matern Fetal Neonatal Med
Aim: To review the evidence on pregnancy outcome and neonates regarding COVID-19 pneumonia.
5/19/20
Effects of coronavirus dis
Juan J, Gil MM, Rong Z, et al. | Ultrasound Obstet Gynecol
Aim: To evaluate the effects of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcomes by performing a systematic review of available published literature on pregnancies affected by COVID-19.
5/19/20
How can healthcare workers
Jones L, Candy B, Roberts N, Ondruskova T, et al | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the management of delirium in patients with COVID-19 and the use of non-pharmacological approaches outside of critical care settings.
5/19/20
Hydroxychloroquine effects
Sachdeva M, Mufti A, Maliyar K, et al. | J Am Acad Dermatol
Aim: To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment.
CANDIDATE THERAPEUTICS
5/19/20
Immunosuppression and COVI
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk and management of people with immunosuppression and COVID-19.
UPDATED
5/19/20
Question: Should smartphon
Tarassenko L, Greenhalgh T | Oxford COVID-19 Evidence Service Team
Aim: Can we use smartphones to measure oxygen saturation?
5/19/20
Rapid Review: Awake Prone
Parhar K, Weatherald J, Solverson K | Alberta Health Services
Aim: To review the evidence on the safety and efficacy of prone positioning in awake non-intubated patients with SARS-CoV-2 pneumonia.
5/19/20
Rapid Review: Rehabilitati
Kania-Richmond A, Koning C, Manhas KP | Alberta Health Services
Aim: To review the evidence on the rehabilitation needs of COVID-19 patients in ICU and in-patient hospital settings.
5/19/20
Telehealth and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence or published standards on telehealth implementation during the COVID-19 pandemic.
UPDATED
5/19/20
The liver injury and gastr
Wang H, Qiu P, Liu J, et al. | Clin Res Hepatol Gastroenterol
Aim: To evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19.
CLINICAL CHARACTERISTICS
5/18/20
Characterisation of COVID-
Mustafa NM, Selim LA | J Clin Virol
Aim: To analyse the disease characterisation in paediatric age group including the possibility of vertical transmission to the neonates.
CLINICAL CHARACTERISTICS
5/18/20
Chest CT for Detecting COV
Xu B, Xing Y, Peng J, et al. | Eur Radiol
Aim: To perform a systematic review and meta-analysis regarding the diagnostic test accuracy of chest CT for detecting coronavirus disease 2019 (COVID-19).
DIAGNOSTICS
5/18/20
LIVING SYSTEMATIC REVIEW:
Mackey K, King VJ, Gurley S, et al. | VA Evidence Synthesis Program
Aim: To synthesize evidence on the role of ACE inhibitor and ARB use on patient outcomes in COVID-19 as well as evidence on the benefits and harms of initiating these medications to treat patients with COVID-19.
UPDATED
WHO COLLABORATIVE
VA ESP
5/18/20
Persistent viral shedding
Gupta S, Parker J, Smits S, et al. | Colorectal Dis
Aim: To establish the incidence and timing of positive faecal samples for SARS-CoV-2 in patients with COVID-19.
5/18/20
Psychiatric and neuropsych
Rogers JP, Chesney E, Oliver D, et al. | Lancet Psychiatry
Aim: To examine the two previous coronavirus epidemics, SARS and MERS, to identify the possible psychiatric and neuropsychiatric implications for the current pandemic. 
5/18/20
Systematic review of the p
Farsalinos K, Barbouni A, Niaura R | Intern Emerg Med
Aim: To systematically examine the prevalence of current smoking among hospitalized patients with COVID-19 in China, considering the high-population smoking prevalence in China (26.6%).
5/18/20
Three months of COVID-19:
Rafiq D, Batool A, Bazaz MA | Rev Med Virol
Aim: To analyse information on progression of the pandemic in the past 3 months and systematically discusses the characteristics of SARS-CoV-2019 virus including its epidemiologic, pathophysiologic, and clinical manifestations.
CLINICAL CHARACTERISTICS
5/15/20
ACEI/ARB Use and Risk of I
Zhang X, Yu J, Pan L, et al. | Pharmacol Res
Aim: To (1) determine whether use of ACRI/ARB is associated with an increase in likelihood of viral infectivity; (2) to investigate whether there are differences in severity and mortality between ACRI/ARB users and non- ACRI/ARB users; (3) and, in particular, to evaluate whether ACRI/ARB exposure was associated with a lower risk of mortality when compared to non-ACRI/ARB antihypertensive drug exposure. 
CANDIDATE THERAPEUTICS
5/15/20
AGA Institute Rapid Review
Sultan S, Altayar O, Siddique SM, et al. | Gastroenterology
Aim: To summarize international data on the Gl and liver manifestations of COVID-19 infection and treatment.
CLINICAL CHARACTERISTICS
5/15/20
Neurological manifestation
Montalvan V, Lee J, Bueso T, et al. | Clin Neurol Neurosurg
Aim: To review the neurological aspects of SARS-cov2 and other coronavirus, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease.
5/15/20
Prognosis of COVID-19 in P
Oyelade T, Alqahtani J, Canciani G | Trop Med Infect Dis
Aim: To evaluate the severity and mortality in COVID-19 patients with underlying kidney and liver diseases.
CLINICAL CHARACTERISTICS
5/14/20
A Systematic Review Analyz
Chauhan RP, Gordon ML | Pathogens
Aim: To summarize the original research articles and case reports of all the four types of influenza viruses reported in swine populations worldwide.
5/14/20
Convalescent Plasma or Hyp
Valk SJ, Piechotta V, Chai KL, et al. | Cochrane Database Syst Rev
Aim: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID?19.
CANDIDATE THERAPEUTICS
5/14/20
Safe management of bodies
Yaacoub S, Schunemann H, Khabasa J, et al. | BMJ Global Health
Aim: To systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies.
UPDATED
WHO COLLABORATIVE
5/14/20
Should azithromycin be use
Gbinigie K, Frie K | BJGP Open
Aim: To review the evidence for the effectiveness and safety of azithromycin in treating COVID-19.
CANDIDATE THERAPEUTICS
5/14/20
Vertical Transmission of S
Yang Z, Liu Y | Am J Perinatol
Aim: To summarize currently available evidence on vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
5/13/20
Anosmia or dysgeusia in CO
Carrillo-Larco RM, Altez-Rodriguez C | Wellcome Open Res
Aim: To determine the frequency of anosmia and dysgeusia in COVID-19 patients, the association of anosmia or dysgeusia with COVID-19 diagnosis, and whether anosmia and dysgeusia are prognostic factors for impaired outcomes among COVID-19 patients.
CLINICAL CHARACTERISTICS
5/13/20
Evidence summary of immuni
 | Health Information and Quality Authority, Ireland
Aim: To review the international evidence on immunity and the spread of the virus by children.
5/13/20
Interventions with the eld
da Silveira Fleck A, Ouedraogo DJ | Center for Research in Public Health
Aim: To review the evidence on the effects of automated calls or live call to assess the mental and physical health needs of elderly and/or vulnerable populations.
5/13/20
Resumption of Health Care
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the resumption of health care services in community or acute care.
5/13/20
Supporting adults bereaved
Mayland CR, Harding AJ, Preston N, et al. | J Pain Symptom Manage
Aim: To review and synthesise learning from previous literature focused on the impact on grief and bereavement during other infectious disease outbreaks.
5/13/20
The role of biomarkers in
Kermali M, Khalsa RK, Pillai K, et al. | Life Sci
Aim: To evaluate different biomarkers to discover if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease.
CLINICAL CHARACTERISTICS
5/12/20
A Rapid Systematic Review
Chowdhury MS, Rathod J, Gernsheimer,J | Acad Emerg Med
Aim: To examine the evidence on chloroquine and hydroxychloroquine as treatments for COVID-19.
CANDIDATE THERAPEUTICS
5/12/20
Chloroquine and hydroxychl
Singh AK, Singh A, Shaikh A, et al. | Diabets Metab Syndr
Aim: To review existing literature and relevant websites regarding these drugs and COVID-19, adverse effects related to drugs, and related guidelines.
CANDIDATE THERAPEUTICS
5/12/20
Convalescent plasma transf
Rajendran K, Narayanasamy K, Rangarajan J, et al. | J Med Virol
Aim: To evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date.
CANDIDATE THERAPEUTICS
5/12/20
Coronavirus disease 2019 (
Yang Z, Wang M, Zhu Z, et al. | J Matern Fetal Neonatal Med
Aim: To summarize currently available evidence on maternal, fetal, and neonatal outcomes of pregnant women infected with Coronavirus Disease 2019 (COVID-19).
5/12/20
COVID-19 in hospitalized c
Streng A, Hartmann K, Armann J, et al. | Monatsschr Kinderheilkd
Aim: To summarize the current scientific evidence regarding the clinical presentation of COVID-19 in hospitalized children based on available case series from China.
CLINICAL CHARACTERISTICS
5/12/20
Obesity as a predictor for
Tamara A, Tahapary DL | Diabetes Metab Syndr
Aim: To study the impact of obesity to the prognosis and disease severity of COVID-19.
5/12/20
Personal protective equipm
Jessop ZM, Dobbs TD, Ali SR, et al. | Br J Surg
Aim: To inform surgeons of appropriate PPE requirements, and to discuss usage, availability, rationing and future solutions.
INFECTION CONTROL
5/12/20
Prevalence, Severity and M
Alqahtani JS, Oyelade T, Aldhahir AM, et al. | PLoS ONE
Aim: To summarize the evidence on the potential severity and mortality risks caused by COVID-19 in patients with COPD.
5/12/20
Rapid Review: Diabetic ret
Ahmad E, Davies MJ, Khunti K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on screening for and managing diabetic retinopathy during the COVID-19 pandemic.
5/12/20
SARS-CoV-2 (COVID-19): Wha
Mehta MS, Mytton OT, Mullins EWS, et al. | Clin Infect Dis
Aim: To summarise current understanding of the epidemiology and transmission dynamics of this coronavirus in children, in order to inform decisions regarding clinical and public health measures for children in the UK.
5/12/20
Should Baricitinib be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of baricitinib as a potential treatment for patients with COVID-19.
5/12/20
Systematic review of recom
Abdelrahman T, Ansell J, Brown C, et al. | BJS Open
Aim: To identify contemporary evidence relating to OR practice in the context of COVID?19.
5/12/20
The impact of 2019 novel c
Li JW, Han TW, Woodward M, et al. | Prog Cardiovasc Dis
Aim: To summarize available data on severity differences in acute cardiac injury and acute cardiac injury with mortality during the COVID-19 outbreak.
5/12/20
Use of Corticosteroids in
Veronese N, Demurtas J, Yang L, et al. | Front Med
Aim: To investigate the effectiveness of glucocorticoid therapy in patients with COVID-19.
CANDIDATE THERAPEUTICS
5/11/20
A systematic review on use
Patil VM, Singhal S, Masand N | Life Sci
Aim: To review the evidence on the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine.
CANDIDATE THERAPEUTICS
5/11/20
Asymptomatic Transmission
Williams S, Walsh C, Bornstein S, et al. | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the significance of asymptomatic/pre-symptomatic transmission of COVID-19.
5/11/20
Can Antimalarials be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of antimalarials, particularly chloroquine or hydroxychloroquine, to treat patients with COVID-19.
5/11/20
Preventing non-COVID-19 ho
Bobrovitz N, Lee J, Mahtani KR | Oxford COVID-19 Evidence Service Team
Aim: To identify a priority list of evidence-based medications for use in the community or emergency department that could prevent emergency hospital admissions among non-COVID patients.  
5/11/20
Rapid Review: Virtual vs I
Modayil M, Cook C, Cook L, et al. | Alberta Health Services
Aim: To review the evidence on the impact of virtual visits compared with or in addition to in-person visits on process outcomes, patient and provider satisfaction, quality of care, and access to provider.
5/11/20
Should Protease Inhibitors
 | Singapore Ministry of Health
Aim: To review the evidence on the use of protease inhibitors for treating COVID-19.
5/11/20
Taste Changes (Dysgeusia)
Aziz M, Perisetti A, Lee-Smith WM, et al. | Gastroenterology
Aim: To assess the presence of ageusia/dysgeusia among COVID-19 patients.
CLINICAL CHARACTERISTICS
5/10/20
Delivering healthcare remo
Neubeck L, Hansen T, Jaarsma T | Eur J Cardiovasc Nurs
Aim: To bring together the evidence for remote healthcare during a quarantine situation period to support people living with cardiovascular disease during COVID-19 isolation.
5/10/20
Efficacy and safety of int
Liu M, Gao Y, Yuan Y, et al. | Pharmacol Res
Aim: To assess the efficacy and safety of Integrated Traditional Chinese and Western Medicine to corona virus disease 2019 (COVID-19). 
CANDIDATE THERAPEUTICS
5/10/20
Liver injury is associated
Parohan M, Yaghoubi S, Seraj A | Hepatol Res
Aim: To summarize available findings on the association between liver injury and severity of COVID-19 infection.
5/10/20
QT prolongation, torsades
Jankelson L, Karam G, Becker ML, et al. | Heart Rhythm
Aim: To conduct a systematic review of the arrhythmogenic effect of short courses of chloroquine or hydroxychloroquine.
CANDIDATE THERAPEUTICS
5/9/20
Anosmia as a presenting sy
Lechner M, Chandrasekharan D, Jumani K, et al. | Rhinology
Aim: To review the literature of SARS-CoV2 infection/COVID-19 and anosmia to help inform management of anosmia in healthcare works. 
CLINICAL CHARACTERISTICS
5/8/20
Prevalence of depression,
Pappa S, Ntella V, Giannakas T, et al. | Brain Behav Immun
Aim: To synthesize and analyze existing evidence on the prevalence of depression, anxiety and insomnia among HCWs during the Covid-19 outbreak.
5/8/20
Rapid review for the anti-
Li Z, Wang X, Cao D, et al. | Drug Discov Ther
Aim: To critically assess the potential anti-coronavirus effect of remdesivir on COVID-19 and other coronaviruses based on the most up-to-date evidence.
CANDIDATE THERAPEUTICS
5/8/20
Saliva sample for testing
Juvet LK, Lauvrak V | Norwegian Institute of Public Health
Aim: To investigate if there are studies supporting the use of salivary samples for detection of SARS-CoV-2, and if there are studies that can be used to calculate the diagnostic accuracy of salivary testing compared to nasopharyngeal or oropharyngeal swab samples.
5/8/20
What is the evidence for o
McQuillan R, Dozier M, Nundy R, et al. | UNCOVER
Aim: To review the evidence on the outdoor transmission of SARS-CoV-2 under the following different approaches: epidemiological, microbiological, mechanistic, and environmental.
5/7/20
Activities delivered at ho
Lloyd-Williams M, Mogan C, Karen SR, et al. | Oxford COVID-19 Evidence Service Team
Aim: To establish the evidence for which non-technology based activities that can be delivered at home by family carers, are effective in maintaining cognitive function in people with dementia who are socially isolating during COVID-19
5/7/20
Activities delivered at ho
Lloyd-Williams M, Mogan C, Russel S, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To establish the evidence for which non-technology based activities that can be delivered at home by family carers, are effective in maintaining cognitive function in people with dementia who are socially isolating during COVID-19.
5/7/20
Environmental scan and ana
Park M | Vancouver Coastal Health
5/7/20
Is oxygen an effective tre
Allsop M, Ziegler L, Fu Y, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for oxygen as a treatment option to alleviate the symptoms of breathlessness for patients dying with COVID-19 and to identify potential harms.
5/7/20
Occurrence, prevention, an
Kisely S, Warren N, McMahon L, et al. | BMJ
Aim: To examine the psychological effects on clinicians of working to manage novel viral outbreaks, and successful measures to manage stress and psychological distress.
5/7/20
Transmission of SARS-CoV-2
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the transmission of SARS-CoV-2 via contact or droplets.
5/6/20
COVID-19 in children with
LeBlanc A | medRxiv
UPDATED
5/6/20
Effectiveness of methods o
da Silveira Fleck A, Ouedraogo DJ | Center for Research in Public Health
Aim: To review the evidence on the effectiveness of disinfection methods for disposable filtering face pieces of type N95.
5/6/20
Epidemiology of and Risk F
Chou R, Dana T, Buckley D, et al. | Ann Intern Med
Aim: To examine the burden of SARS-CoV-2, SARS-CoV-1, and Middle Eastern respiratory syndrome (MERS)-CoV on HCWs and risk factors for infection, using rapid and living review methods.
WHO COLLABORATIVE
5/6/20
Rapid Review: Recommendati
Chen J | Alberta Health Services
Aim: To review the evidence on the use of antibacterial therapy upon admission for patients with respiratory symptoms who have suspected or confirmed COVID-19.
5/6/20
Should Interleukin-6 Inhib
 | Singapore Ministry of Health
Aim: To review the evidence on the use of interleukin-6 (IL-6) inhibitors, particularly tocilizumab, to manage symptoms of patients with COVID-19.
5/6/20
What is the evidence for t
Theodoratou E, Dozier M, Li X, et al. | UNCOVER
Aim: To review the evidence on COVID-19 transmission routes among infected children and adolescents.
5/5/20
A Rapid Scoping Review: Wh
Biro S | KFL&A Public Health
Aim: To review the evidence on the factors, considerations, and criteria that should be in place to limit infection risk while lifting restrictions at a regional level in Canada.
5/5/20
BAME COVID-19 DEATHS – Wha
Razaq A, Harrison D, Karunanithi S, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence on plausible associations between ethnicity and COVID-19 incidence and adverse health outcomes in the general population and people working in health and social care.
5/5/20
COVID-19, Modern Pandemic:
Balla M, Merugu GP, Patel M, et al. | J Clin Med Res
Aim: To provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. 
5/5/20
Factors associated with mo
Martins-Filho PR, Tavares CSS, Santos VS | Eur J Intern Med
Aim: To comprehensively review studies of clinical and laboratory features of hospitalized patients with COVID-19.
CLINICAL CHARACTERISTICS
5/5/20
Impact of corticosteroid t
Li H, Chen C, Hu F, et al. | Leukemia
Aim: To determine safety and efficacy of corticosteroids in SARS-CoV-2, SARS-CoV, and MERS-CoV infections.
CANDIDATE THERAPEUTICS
5/5/20
Lifting Regional Restricti
Biro S | KFL&A Public Health
5/5/20
Rapid HTA of alternative d
 | Health Information and Quality Authority, Ireland
Aim: To identify a wide range of diagnostic tests for detecting and confirming COVID-19 cases.
5/4/20
Being Outside Safely and C
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the transmission of COVID-19 in outdoor settings.
5/4/20
COVID-19: Case fatality ra
Juvet LK, Laake I, Vestrheim DF | Norwegian Institute of Public Health
Aim: To review the literature on the case fatality rate and infection fatality rate for serious cases of COVID-19.
5/4/20
Immunity after SARS-CoV-2
Flodgren GM | Norwegian Institute of Public Health
Aim: To review the evidence on immunity to COVID-19 after infection by SARS-CoV-2.
5/4/20
Is the 'Lifelight' app ade
Tarassenko LJ, McManus R, Greenhalgh T | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of the Lifelight app to measure blood pressure.
5/4/20
Should Remdesivir be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of remdesivir as a potential treatment for patients with COVID-19.
5/4/20
The role of children as am
Mackey S, Warren C | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the role of children in the transmission of COVID-19.
5/3/20
Overcoming the bottleneck
Esbin MN, Whitney ON, Chong S, et al. | RNA
Aim: To present a collection of these recent advances in COVID-19 nucleic acid testing, including both peer-reviewed and preprint articles.
DIAGNOSTICS
5/2/20
A rapid systematic review
Chowdhury M, Rathod J, Gernsheimer J | Acad Emerg Med
Aim: To review literature currently available regarding the clinical use of CQ and HCQ as treatment in COVID-19 patients in an effort to catalog their recommendations and assess drug efficacy.
CANDIDATE THERAPEUTICS
5/2/20
Bacterial and fungal co-in
Rawson TM, Moore L, Zhu N, et al. | Clin Infect Dis
Aim: To explore and describe the current literature surrounding bacterial/fungal co-infection in patients with coronavirus infection.
5/1/20
Chloroquine / Hydroxychlor
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of cholorquine and hydroxychloroquine in COVID-19.
5/1/20
How have population-level
Li Y, Nair H, Kulkarni D, et al. | UNCOVER
Aim: To review the evidence on how population-level non-pharmaceutical interventions to reduce the transmission of COVID-19 is related to the reproduction number R.
5/1/20
Re-infection and Sustained
Williams S, Walsh C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the liklihood of reinfection and the significance of sustained viral detection after incubation period is complete.
5/1/20
Vitamin D: A rapid review
Lee J, van Hecke O, Roberts N | Oxford COVID-19 Evidence Service Team
Aim: To review the clinical evidence that vitamin D has a role in preventing or treating COVID-19.
4/30/20
An updated systematic revi
Shiozawa P, Uchida RR | Braz J Psychiatry
Aim: To review the evidence on emergency psychological crisis intervention during the COVID-19 outbreak.
4/30/20
Efficacy and safety of cur
Zhong H, Wang Y, Zhang Z, et al. | Pharmacol Res
Aim: To evaluate the efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome (MERS) besides COVID-19, in an attempt to identify promising therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients.
CANDIDATE THERAPEUTICS
4/30/20
Smoking in acute respirato
Hartmann-Boyce J, Lindson N | Oxford COVID-19 Evidence Service Team
4/30/20
The role of children in th
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the role of children in the transmission of SARS-CoV-2.
4/29/20
A rapid review of evidence
Janssens GO, Mandeville HC, Timmermann B, et al. | Radiother Oncol
Aim: To derive evidence-based recommendations for the optimal utilisation of resources during unexpected shortage of radiotherapy capacity.
4/29/20
COVID-19 rapid response an
 | INESSS, Quebec
Aim: To identify alternative drugs to propofol currently used in the constitution of marketing authorization kits while taking into account current and anticipated stock-outs of alternative drugs.
4/29/20
Is there an association be
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection.
4/29/20
Is there an association be
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection.
4/29/20
Is there an association be
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection. 
4/29/20
Rapid Review: The role of
Checkley S, Rogers L, Caffrey N, et al. | Alberta Health Services
Aim: To review the evidence that centralized voluntary isolation/quarantine centers (CVICs) reduce transmission and spread.
4/29/20
Rapid Review: What are the
Asadi L | Alberta Health Services
Aim: To explore evidence based strategies beyond home self-isolation and use of centralized voluntary isolation centers (eg: wearing masks within the home; additional cleaning; testing, other) that have been used to successfully control focal COVID-19 outbreaks in other settings.
4/29/20
Rapid Review: what asympto
Boyd J | Alberta Health Services
Aim: To review the evidence on whether there are populations of asymptomatic individuals (e.g., population sampling; congregate living including LTC, vulnerable populations; patients being hospitalized, those associated with outbreaks, HCWs) that should be considered priority for screening for COVID 19 infection (with RTPCR), with the goal of surveillance and preventing spread within these populations.
4/29/20
What is the evidence on et
McQuillan R, Dozier M, Theodoratou E, et al. | UNCOVER
Aim: To review the evidence on differences in COVID-19 incidence and outcomes based on ethnic variation.
4/28/20
Do we know the diagnostic
Bachelet VC | Medwave
Aim: To find and discuss studies on laboratory diagnostic tests and rapid viral diagnosis. 
DIAGNOSTICS
4/28/20
Environmental scan of lock
Park M | Vancouver Coastal Health
Aim: To review the evidence on lockdown de-escalation measures in response to COVID-19.
4/28/20
Evidence-based Strategies
 | ECRI
Aim: To review evidence and guidelines on interventions to supplement standard weaning practices to reduce ventilator time and avoid repeat intubation in patients with COVID-19.
4/28/20
Hand cleaning with ash for
Paludan-Müller  AS, Boesen  K, Klerings  I, et al. | Cochrane Database Syst Rev
Aim: To assess the benefits and harms of hand cleaning with ash compared with hand cleaning using soap or other materials for reducing the spread of viral and bacterial infections.
INFECTION CONTROL
4/28/20
Management of acute behavi
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance on the management of acute behavioural disturbance during COVID-19.
4/28/20
Psychosocial impact of qua
Rohr S, Muller F, Jung F, et al. | Psychiatr Prax
Aim: To collect evidence on the psychosocial consequences of quarantine measures in severe coronavirus outbreaks prior to COVID-19. 
4/28/20
Should Favipiravir be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of favipiravir for treating COVID-19.
4/28/20
Should Ibuprofen be Used f
 | Singapore Ministry of Health
Aim: To review the evidence on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, to manage symptoms of COVID-19.
4/28/20
What is the evidence for u
Gbinigie K, Frie K | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for the safety and effectiveness of using macrolides to treat COVID-19.
4/27/20
Curating evidence on menta
Thombs BD, Bonardi O, Rice DB, et al. | J Psychosomatic Res
Aim: To evaluate (1) levels of mental health symptoms, prioritizing studies that assess changes in symptoms from pre-COVID-19 or compare concurrent samples between participants with different experiences with COVID-19 (e.g., those infected versus healthy comparison sample); (2) factors associated with levels or changes in symptoms during COVID-19, and (3) the effect of interventions on mental health symptoms during COVID-19.
4/27/20
Factors Informing Clinical
 | ECRI
Aim: To examine the effectiveness of triage systems for identifying disease severity and mortality risk to inform decisions on scarce resource allocation during pandemics.
4/27/20
How is immunosuppressive s
Minotti C, Tirelli F, Barbieri E, et al. | J Infect
Aim: To systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population.
4/27/20
Inhaled corticosteroids an
Halpin D, Singh D, Hadfield RM | Eur Respir J
Aim: To evaluate whether pre-morbid use or continued administration of inhaled steroids is a risk factor for adverse outcomes in acute respiratory infections due to COVID-19, SARS or MERS. 
WHO COLLABORATIVE
CANDIDATE THERAPEUTICS
4/27/20
Mortality in COVID-19 pati
Kernohan A, Boath A, Calderon M, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify relevant studies to inform evidence-based patient management and care pathway development.
4/27/20
What is the evidence about
Wilson, MG, Waddell K, Gauvin FP, et al. | McMaster Health Forum
Aim: To identify evidence on international and Canadian experiences with asymptomatic screening to identify COVID-19 cases and to prevent transmission.
4/26/20
Cohorting in Long-term Car
Williams S, Walsh C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on cohorting of residents in long-term care facilities who test positive for COVID-19.
4/25/20
Systematic review of impor
Chauhan R, Dessie ZG, Noreddin A, et al. | Pathogens
Aim: To highlight the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa to better understand the trend of emerging and re-emerging virus diseases within the African continent.
4/24/20
COVID-19 in cardiac arrest
Couper K, Taylor-Phillips S, Grove A, et al. | Resuscitation
Aim: To identify the potential risk of transmission associated with key interventions (chest compressions, defibrillation, cardiopulmonary resuscitation) to inform international treatment recommendations.
4/24/20
COVID-19 rapid response an
 | INESSS, Quebec
Aim: To examine the evidence on COVID-19 in pediatric clinical care.
4/24/20
Does BCG vaccination prote
Soliman R, Brassey J, Pluddemann A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the current evidence about the protective effects of BCG vaccine against acute respiratory infections and COVID-19.
4/24/20
Plastic or reusable aeroch
Brett K, Walter M | CADTH
Aim: To examine the evidence regarding the clinical effectiveness of plastic or reusable aerochambers in multi-dose inhalers for patients requiring medication administration, as well as any evidence-based guidelines on the topic.
4/24/20
Portable or Temporary Nega
Kumar D, Severn M | CADTH
Aim: To identify available evidence on the clinical effectiveness of portable or temporary negative pressure rooms and related evidence-based guidelines for the management of people with active tuberculosis.
4/23/20
Severe acute respiratory s
Castagnoli R, Votto M, Licari A, et al. | JAMA Pediatr
Aim: To evaluate currently reported pediatric cases of SARS-CoV-2 infection.
4/22/20
Are Non-Steroidal Anti-Inf
Erdmann R, Kania-Richmond A | Alberta Health Services
Aim: To review the evidence on whether patients who are on prescribed NSAIDS as chronic therapy should stop taking these drugs if they develop COVID-19.
4/22/20
Barriers and facilitators
Houghton C, Meskell P, Delaney H, et al. | Cochrane Database of Systematic Reviews
Aim: To identify barriers and facilitators to healthcare workers' adherence to IPC guidelines for respiratory infectious diseases.
INFECTION CONTROL
4/22/20
Cancer patients and resear
Moujaess E, Kourie HR, Ghosn M | Crit Rev Oncol Hematol
Aim: To expose the challenges of cancer management in the era of SARS-CoV-2, the epidemiological, clinical, pathological and radiological characteristics of the disease in cancer patients and its outcomes on this population.
CLINICAL CHARACTERISTICS
4/22/20
COVID-19 and the social an
Chastenay M | INESSS, Quebec
Aim: To review the evidence on social and mental health services to promote a return to normal life during the recovery phase of a pandemic or similar crisis.
4/22/20
CT imaging features of 4,1
Zhu J, Zhong Z, Li H, et al. | J Med Virol
Aim: To systematically review the CT imaging features of COVID-19 in order to provide reference for clinical practice.
CLINICAL CHARACTERISTICS
4/22/20
Is it safe for patients wi
Kalin A, Waqar S, Ghouri N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To provide guidance to clinicians looking after patients with symptoms of COVID-19 who are thinking about fasting in Ramadan.
4/22/20
Non-invasive ventilation a
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on community or home-based non-invasive ventilation (NIV) and inspiratory muscle training (IMT) for people with spinal cord injuries during COVID-19.
4/22/20
Prevalence and severity of
Hu Y, Sun J, Dai Z, et al. | J Clin Virol
Aim: To evaluate the risk factors of COVID-19. 
4/22/20
Rapid Review: What factors
Jelinski S, Mackay E | Alberta Health Services
Aim: To review the evidence on patient demographic or clinical factors that are associated with positive COVID-19 test results.
4/22/20
Transmission of Acute Resp
Clement F  | University of Calgary
Aim: To review the clinical evidence for the risk of transmission of acute respiratory infections to health care workers caring for patients undergoing aerosol-generating medical procedures.
4/22/20
What conditions could we p
Stravropoulou C, Palmer VJ, Burls A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To examine the evidence on the conditions that most often lead to potentially preventable unplanned hospital admissions that are manageable in primary care.
4/22/20
What prognostic clinical r
Urwin SG, Kandola G, Graziado S | Oxford COVID-19 Evidence Service Team
Aim: To provide a quick reference summary of prognostic clinical risk prediction scores that are currently available in an accessible format and methodologically suitable for use in the community following a potential infection with the SARS-CoV-2 virus causing COVID-19, or people with suspected or confirmed COVID-19.
4/22/20
Which COVID-19 patients ar
Sharpe H, McLane P | Alberta Health Services
Aim: To review the evidence on criteria or simple tools that can be used to determine which patients with suspected/confirmed COVID-19 are stable and appropriate for safe discharge from hospital or an alternate care centre.
4/22/20
Which occupations and acti
Carver C, Guyan M, Pierre M | UNCOVER
Aim: To review the evidence on which high proximity activites in the UK would benefit from mask wearing to reduce the transmission of COVID-19.
4/21/20
A systematic review of pub
Strict A, Hartmann K, Armann J, et al. | Übersichten
Aim: To summarize the current scientific evidence on the clinical course of COVID-19 in hospitalized children.
4/21/20
Antiviral therapy in manag
Yousefifard M, Zali A, Mohamed A, et al. | Arch Acad Emerg Med
Aim: To evaluate the efficacy of antiviral therapies in treatment of COVID-19.
CANDIDATE THERAPEUTICS
4/21/20
Clinical characteristics a
Chang T, Wu J, Chang L | J Formos Med Assoc
Aim: To collect current evidence about COVID-19 in children.
4/21/20
COVID-19 and pregnancy/lac
 | INESSS, Quebec
Aim: To examine the evidence on COVID-19 and breastfeeding.
4/21/20
Supportive treatment with
Alzghari SK, Acuna VS | J Clin Virol
Aim: To evaluate outcomes associated with TCZ treatment in patients with COVID-19.
CANDIDATE THERAPEUTICS
4/21/20
Testing before surgery
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preoperative testing of COVID-19 for patients undergoing surgery.
UPDATED
4/21/20
What is the efficacy and s
Greenhalgh T, Javid B, Knight M, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on tests to confirm or exclude exertional desaturation.
4/20/20
Are interventions such as
Jones N, Carver C | Oxford COVID-19 Evidence Service Team
Aim: Does current evidence support social distancing of asymptomatic healthcare workers from other household members or other interventions specific to healthcare workers to reduce the risk of transmitting COVID-19?
4/20/20
Cloth Face Coverings Worn
 | ECRI
Aim: To review the evidence on the general public’s use of these face coverings for reducing the transmission risk of viral respiratory infection.
4/20/20
Diabetic patients with COV
Roncon L, Zuin M, Rigatelli G, et al. | J Clin Virol
Aim: To assess the risk of ICU admission and morality risk in diabetic COVID-19 patients.
4/20/20
Infrared Temperature Scree
 | ECRI
Aim: To examine the accuracy of external infrared temperature screening devices for identifying infected people.
4/20/20
Rapid Review: Effectivenes
Asadi L | Alberta Health Services
Aim: To review the evidence on the effectiveness of wearing medical masks, including home-made masks, to reduce the spread of COVID-19 in the community.
4/20/20
The clinical effectiveness
 | Health Technology Wales
Aim: To review the evidence on the effectiveness of virus and antibody tests to inform COVID-19 diagnosis.
4/20/20
What clinical features or
Greenhalgh T, Treadwell J, Burrow R, et al. | Oxford COVID-19 Evidence Service Team
Aim: In people in the community with suspected or confirmed COVID-19, are there demographic features, other conditions, symptoms, or signs that are prognostic factors for 30-day all-cause mortality, ventilation, or ICU care?
4/20/20
What is known about the sp
Waddell K, Gauvin FP, Wilson MG, et al. | McMaster Health Forum
Aim: To identify evidence on the spread and management of COVID-19 in non-health workplaces, including workplaces where light-touch services are offered such as government administration offices (e.g., Service Canada or Service Ontario) and social services (e.g., group homes for high-needs individuals).
4/20/20
What is the effectiveness
Theodoratou E, Dozier M, Guyan M, et al. | UNCOVER
Aim: To review the evidence on the efficacy of face masks in preventing respiratory transmission in the community.
4/20/20
Which Patients with suspec
Cunningham C, Cook C | Alberta Health Services
Aim: To review the evidence on predictive tools or tests that can assist in deciding who is at risk of clinical deterioration and should be assessed in the emergency department.
4/19/20
Are homemade facemasks eff
McQuillan R, Narain A, Dozier M | UNCOVER
Aim: To review the evidence on the efficacy of homemade facemaks at reducing transmission of COVID-19 in community settings.
4/19/20
Cardiac injury is associat
Santoso A, Pranata R, Wibowo A, et al. | Am J Emerg Med
Aim: To explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia
4/19/20
Does the use of face masks
 | UNCOVER
Aim: To review the evidence on the effect of face masks in the general population in reducing the spread of infection.
4/18/20
A living systematic review
Della Gatta A, Rizzo R, Pilu G, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the clinical outcomes reported for pregnant patients with coronavirus disease 2019.
UPDATED
4/18/20
Clinical Characteristics o
Panahi L, Amiri M, Pouy S | Arch Acad Emerg Med
Aim: To review articles published on clinical manifestations and characteristics of children and infants with COVID-19.
CLINICAL CHARACTERISTICS
4/18/20
COVID19 during pregnancy:
Gatta D, Nunzia A, Rizzo R, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the outcomes reported for pregnant patients with COVID 19. 
4/17/20
Allocation of Scarce Resou
Romney D, Fox H, Carlson S, et al. | Disaster Med Public Health Prep
Aim: To locate and analyze U.S. State Crisis Standards of Care (CSC) documents to determine their prevalence and quality.
4/17/20
Benefits of Exercise on In
Song Y, Ren F, Sun D, et al. | Int J Environ Res Public Health
Aim: To summarize the recent scientific evidence that outlines the effects of exercise on influenza or pneumonia in older adults.
4/17/20
Central nervous system man
Asadi-Pooya AA, Simani L | J Neruol Sci
Aim: To discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.
CLINICAL CHARACTERISTICS
4/17/20
COVID-19 and outdoor safet
 | National Collaborating Centre for Environmental Health
Aim: To review the evidence on precautions needed to mitigate community spread of SARS-CoV-2 in outdoor environment
4/17/20
COVID-19 and Remdésivir [F
 | INESSS, Quebec
Aim: To evaluate the efficacy of remdesivir in post-exposure prophylaxis of SARS-Cov2 infection.
4/17/20
COVID-19: The relationship
Brurberg KG, Fretheim A | Norwegian Institute of Public Health
Aim: To review the evidence on the association between age, comorbidity, and disease severity in patients with COVID-19.
4/17/20
Diabetes mellitus is assoc
Huang I, Lim MA, Pranata R | Diabetes Metab Syndr
Aim: To investigate the association between DM and poor outcome in patients with COVID-19 pneumonia.
4/17/20
Pre-Treatment Mouth Rinses
Dulong C, Frey N, Walter M | CADTH
Aim: To summarize studies on the clinical effectiveness of using pre-dental treatment mouth rinses for patients with suspected SARS or COVID-19 in order to prevent virus transmission from patients to oral health care providers.
4/17/20
Should Convalescent Plasma
 | Singapore Ministry of Health
Aim: To review the evidence on the use of convalescent plasma in patients with COVID-19.
4/17/20
Therapeutic Management of
Tobaigy M, Qashgary M, Al-Dahery S, et al. | Infect Prev Pract
Aim: To report any evidence of therapeutics used for the management of COVID-19 patients in clinical practice since the emergence of the virus.
CANDIDATE THERAPEUTICS
4/17/20
Virological and Clinical C
Sarma P, Kaur H, Kumar H, et al. | J Med Virol
Aim: To examine the evidence for the safety and efficacy of hydroxycholorquine in COVID-19.
CANDIDATE THERAPEUTICS
4/16/20
Biotherapies Directed Agai
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of using biotherapies directed againts IL-6 or its receptor in COVID-19.
4/16/20
Clinical characteristics o
Zhu J, Ji P, Pang J, et al. | J Med Virol
Aim: To systematically review the clinical characteristics of Coronavirus disease 2019 (COVID?19).
CLINICAL CHARACTERISTICS
4/16/20
COVID-19 and palliative ca
 | INESSS, Quebec
Aim: To review the evidence on palliative care and drug shortages during the COVID-19 pandemic.
4/16/20
COVID-19 and shortage of s
 | INESSS, Quebec
Aim: To review the evidence on alternative drugs for sedation during the COVID-19 pandemic.
4/16/20
Does physical exercise pre
McCall MC, Heneghan C, Nunan D | Oxford COVID-19 Evidence Service Team
Aim: To examine the current evidence about the effectiveness of physical exercise in preventing or treating acute respiratory infection.
4/16/20
Does physical exercise pre
McCall MC, Heneghan C, Nunan D | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effectiveness of physical exercise in preventing or treating acute respiratory infection.
4/16/20
Effectiveness of hydroxych
Hastings S, et al. | Alberta Health Services
Aim: To explore the evidence for and risks of using hydroxychloroquine (HQ) as a treatment and prophylaxis for SARS-CoV-2.
4/16/20
Safety of Extended Use and
 | ECRI
Aim: To review the evidence on the safety of extending the use of N95 respirator masks.
4/16/20
Starting or resuming cance
Pujadas-Botey A | Alberta Health Services
Aim: To review the evidence on strategies for assessing patients who were infected with COVID-19 for suitability for starting or resuming cancer treatment.
4/16/20
What clinical practice gui
Kostaras X | Alberta Health Services
4/16/20
What is the effectiveness
Coles B, Burton C, Khunti K, et al. | Oxford COVID-19 Evidence Service Team
Aim: What is the efficacy of aprons compared to gowns in primary care settings?
4/16/20
What is the efficacy of ap
Coles B, Burton C, Khunti K, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the efficacy of protective gowns versus aprons in primary care settings.
4/15/20
Analysis of Maternal Coron
Muhidin S, Moghadam ZB, Vizheh M | Arch Acad Emerg Med
Aim: To clarify the impact of novel coronavirus disease (COVID-19) on pregnant patients and maternal and neonatal outcomes.
4/15/20
Clinical presentation of C
Lovato A, de Filippis C | Ear Nose Throat J
Aim: To perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. 
CLINICAL CHARACTERISTICS
4/15/20
Clinical sensitivity and s
Hastings S, et al. | Alberta Health Services
Aim: To explore how the testing characteristics for the Alberta Health Services lab-developed test for COVID-19 differ between samples collected from nasal, nasopharyngeal, and throat swabs.
4/15/20
COVID-19 - Reducing Health
MacPherson F | BC Ministry of Health
Aim: To identify which infection prevention and control interventions, programs, infrastructure are most effective at reducing health care associated infections in Long Term Care facilities.
4/15/20
COVID-19 and general consi
 | INESSS, Quebec
Aim: To review the evidence on general considerations for cancer treatment in patients with COVID-19.
4/15/20
Extended Use and Layering
 | Ontario Health Quality
Aim: To examine the recommendations and literature on the extended use and layering of N95 respirators and use of expired personal protective equipment during the COVID-19 pandemic.
4/15/20
Mental health of healthcar
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the pyschological impact of COVID-19 on healthcare workers.
4/15/20
Personal protective equipm
Verbeek  JH, Rajamaki  B, Ijaz  S, et al. | Cochrane Database Syst Rev
Aim: To evaluate which type of full?body PPE and which method of donning or doffing PPE have the least risk of contamination or infection for HCW, and which training methods increase compliance with PPE protocols.
INFECTION CONTROL
4/15/20
The proportion of patients
Zhou M, Qi J, Li X, et al. | Br J Haematol
Aim: To analyse the proportion of patients with thrombocytopenia in SARS?CoV, MERS?CoV and 2019?nCoV infections.
CLINICAL CHARACTERISTICS
4/14/20
A systematic review of the
Shah S, Das S, Jain A, et al. | Int J Rheum Dis
Aim: To systematically review the role of CQ and HCQ in preventing the spread of COVID-19.
CANDIDATE THERAPEUTICS
4/14/20
Arterial hypertension and
Zuin M, Rigatelli G, Zuliani G, et al. | J Infect
Aim: To evaluate the risk of death in COVID-19 infection patients with and without HT.
4/14/20
Clinical characteristics o
Fu L, Wang B, Yuan T, et al. | J Infect
Aim: To better inform efforts to treat and control the current outbreak with a comprehensive characterization of COVID-19.
CLINICAL CHARACTERISTICS
4/14/20
Coronavirus Disease 2019 (
Bao C, Liu X, Zhang H, et al. | J Am Coll Radiol
Aim: To provide a summary of evidence on detection of COVID-19 by chest CT and the expected CT imaging manifestations.
CLINICAL CHARACTERISTICS
4/14/20
COVID-19 rapid evidence su
 | NICE
Aim: To assess the best available evidence to determine the risk of developing COVID-19 due to acute use of NSAIDs and if doing so can lead to increased risk of developing more severe symptoms of COVID-19.
4/14/20
How can pandemic spreads b
Koshkouei M, Abel L, Pilbeam C | Oxford COVID-19 Evidence Service Team
Aim: To evaluate available measures to minimise the risk of infection spread among residents and staff within care home settings.
4/14/20
Hydroxychloroquine for COV
Ferner RE, Aronson JK | Oxford COVID-19 Evidence Service Team
Aim: To examine the protocols and preliminary trial reports of early clinical trials involving hyroxychloroquine.
4/14/20
Lopinavir/ritonavir: A rap
Dorward J, Gbinigie K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence for the use of Lopinavir/ritonavir (LPVr) as a treatment for COVID-19.
4/14/20
N-acetylcysteine: A rapid
Van Hecke O, Lee J | Oxford COVID-19 Evidence Service Team
Aim: To conduct a rapid review of NAC with specific emphasis on its potential for early administration in the community for patients at greater risk of severe COVID-19.
4/14/20
Optimization of N95 Respir
 | CADTH
Aim: To summarize current recommendations about the use of N95 respirator masks.
4/14/20
The effect of corticostero
Yang Z, Liu J, Zhou Y, et al. | J Infect
Aim: To further evaluate the influence of corticosteroids on patients with coronavirus infection.
CANDIDATE THERAPEUTICS
4/14/20
What is known about approa
Wilson MG, Gauvin FP, Waddell K, et al. | McMaster Health Forum
Aim: To identify evidence on strategies for conserving, re-using, and repurposing different kinds of masks.
4/13/20
Likelihood of asymptomatic
Hastings S, et al. | Alberta Health Services
Aim: To explore the evidence supporting the possibility of asymptomatic transmission of SARS-CoV-2.
4/13/20
Tools to support communica
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on emerging tools that are being used to support communication between patients and their loved ones during the COVID-19 pandemic.
4/13/20
Triage tools for ICU admis
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the triage tools that are available to guide decisions about admission to ICU during COVID-19.
4/12/20
Dedicated or temporary COV
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of dedicated hospitals and wards exclusively for the use of COVID-19 patients.
4/12/20
Palliative care and COVID-
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the organization of palliative care services during COVID-19 (or previous pandemics).
4/12/20
The role and response of p
Etkind SN, Bone AE, Lovell N, et al. | J Pain Symptom Manage
Aim: To synthesise evidence for the role and response of palliative care and hospice teams to viral epi/pandemics, to inform the COVID-19 pandemic response.
CLINICAL CHARACTERISTICS
4/11/20
Decontaminating N95 masks
O'Hearn K, Gertsman S, Sampson M, et al. | CADTH
Aim: To synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) on N95 FFR decontamination.
4/11/20
Modes of transmission for
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence about COVID-19 modes of transmission?
4/10/20
Clinical risk prediction t
Jelinski S | Alberta Health Services
Aim: To review the evidence on risk prediction tools to guide admission disposition and management decisions for patients with COVID-19 who are admitted to the hospital.
4/10/20
Continuous Positive Airway
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether continuous positive airway pressure (CPAP) and/or Bilevel Positive Airway Pressure (BiPAP) are aerosol generating, and to locate guidelines on the use of CPAP as a substitute for ventilators during the COVID-19 pandemic.
4/10/20
Indicators for intubation
Sharpe H | Alberta Health Services
Aim: To review the evidence on clinical features that reliably indicate need for intubation or mechanical ventilation.
4/10/20
Patient risk stratificatio
McLane P | Alberta Health Services
Aim: To review the evidence on admission or safe discharge of patients with suspected or confirmed COVID-19 from the emergency department
4/10/20
School closure and managem
Viner RM, Russell SJ, Croker H, et al. | Lancet Child Adolesc Health
Aim: To identify what is known about the effectiveness of school closures and other school social distancing practices during coronavirus outbreaks.
INFECTION CONTROL
4/10/20
The possible of immunother
Aminjafari A, Ghasemi S | Int Immunopharmacol
Aim: To evaluate the existing evidence and experience related to immunotherapy for 2019-nCoV.
CANDIDATE THERAPEUTICS
4/9/20
COVID-19 and Lopinavir [Fr
 | INESSS, Quebec
Aim: To evaluate the use of the lopinavir-ritonavir combination in post-exposure prophylaxis of SARS-Cov2 infection.
4/9/20
COVID-19 and social safety
Chastenay M | INESSS, Quebec
Aim: To review the evidence on maintaining a community safety net for children and youth at risk of being abused during a pandemic.
4/9/20
Digital Stethoscope for Pa
Dulong C, MacDougall D | CADTH
Aim: To search for evidence-based guidelines related to the use of digital stethoscopes for pulmonary auscultation in patients with suspected or confirmed infectious disease.
4/9/20
Quarantine alone or in com
Nussbaumer-Streit B, Mayr V, Dobrescu AI, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the effects of quarantine (alone or in combination with other measures) of individuals who had contact with confirmed cases of COVID19, who travelled from countries with a declared outbreak, or who live in regions with high transmission of the disease.
WHO COLLABORATIVE
INFECTION CONTROL
4/9/20
Rapid review of the use of
Stern D, Lopez-Olmedo N, Perez-Ferrer C, et al. | Salud publica de Mexico
Aim: To assess the effectiveness of using surgical masks in community settings to reduce the probability of infection by SARS-CoV-2 or other acute viral respiratory infection, compared to not using surgical masks
INFECTION CONTROL
4/9/20
SARS-CoV-2 Longevity on an
Kumar D, Walter M, Frey N | CADTH
Aim: To review the available evidence on the lifespan of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on different materials, as well as its potential for transmission via these materials
4/9/20
Should chloroquine and hyd
Gbinigie K, Kerstin F | BJGP Open
Aim: To establish the current evidence for the effectiveness of CQ and HCQ in treating COVID-19.
CANDIDATE THERAPEUTICS
4/8/20
Associations Between Immun
Russel B, Moss C, George G, et al. | Ecancermedicalscience
Aim: To examine the effects of immuno-suppressive and stimulating drugs on host immunity against COVID-19.
4/8/20
COVID-19 and diagnostic as
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on the effectiveness and feasibility of assessing autism spectrum disorder in children remotely in the context of the COVID-19 pandemic.
4/8/20
Diabetes and risks from CO
Hartmann-Boyce J, Morris E, Goyder C, et al. | Oxford COVID-19 Evidence Service Team
4/8/20
Differentiating viral from
Heneghan C, Pluddemann A, Mahtani KR | Oxford COVID-19 Evidence Service Team
4/8/20
Managing diabetes during t
Hartmann-Boyce J, Morris E, Goyder C, et al. | Oxford COVID-19 Evidence Service Team
4/8/20
Maternal and Perinatal Out
Zaigham M, Andersson O | Acta Obstet Gynecol Scand
Aim: To summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy
CLINICAL CHARACTERISTICS
4/8/20
NEWS (or NEWS2) score when
Greenhalgh T, Treadwell J, Burrow R, et al. | Oxford COVID-19 Evidence Service Team
Aim: To establish the state of knowledge, ignorance and uncertainty in relation to the use of NEWS2 in the context of COVID-19 in primary care.
4/8/20
Psychological distress and
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on psychological distress and mental health in healthcare workers during the COVID-19 pandemic.
4/8/20
Re-infection and immunity
Hastings S | Alberta Health Services
Aim: To review the evidence on whether people with previous COVID-19 infection can become re-infected by the SARS-CoV-2 virus.
4/8/20
Should people with chronic
Kalin A | Oxford COVID-19 Evidence Service Team
4/8/20
Suppressing COVID-19 Epide
El-Jardali F, Fadlallah R, Daher N, et al. | Knowledge to Policy Center
Aim: To provide guidance for suppressing COVID-19 through community-centered care approach.
4/8/20
What is the effectiveness
Rios P, Radhakrishnan A, Antony J, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify safe and effective medical countermeasures to address the current outbreak of a novel coronavirus (COVID-19).
4/8/20
What is the role of imagin
Green K, Allen AJ, Suklan J | Oxford COVID-19 Evidence Service Team
Aim: To describe the approaches to clinical investigations following a negative RT-PCR results as described in guidelines from China, Italy, Spain, UK and US. 
4/7/20
Cloth (Fabric) Masks as an
 | Ontario Health Quality
Aim: To examine the recommendations and literature on cloth (fabric) masks during the COVID-19 pandemic.
4/7/20
Gastrointestinal Manifesta
Cheung KS, Hung IF, Chan PP, et al. | Gastroenterology
Aim: To review the published gastrointestinal symptoms and detection of virus in stool, and also summarize data from a cohort of patients with COVID-19 in Hong Kong.
CLINICAL CHARACTERISTICS
4/7/20
Molecular and antibody poi
Green K, Graziadio S, Turner P, et al. | Oxford COVID-19 Evidence Service Team
Aim: To summarize the characteristics of current molecular and antibody diagnostic tests available to support the diagnosis and management of patients with suspected COVID-19.
4/7/20
N95 Equivalents as an Alte
 | Ontario Health Quality
Aim: To examine the recommendations and literature on N95 equivalents from other countries during the COVID-19 pandemic.
4/7/20
Powered Air Purifying Resp
 | Ontario Health Quality
Aim: To examine the guidelines and published literature on 3D printing of N95 respirators and face shields during the COVID-19 pandemic.
4/7/20
What is the evidence that
Khunti K | Oxford COVID-19 Evidence Service Team
4/6/20
Cardiopulmonary resuscitat
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether cardiopulmonary resuscitation is aerosol generating.
4/6/20
COVID-19 and Homelessness
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on effective interventions for homeless people during the COVID-19 pandemic.
4/6/20
COVID-19 rapid response an
 | INESSS, Quebec
Aim: To document the ethical guidelines for demonstrating treatment effectiveness by clinical research.
4/6/20
COVID-19: What proportion
Heneghan C, Brassey J, Jefferson T | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the proportion of COVID-19 cases that are asymptomatic.
4/6/20
Is a 14-day quarantine eff
McCall MC, Nunan D, Heneghan C | Oxford COVID-19 Evidence Service Team
4/4/20
COVID-19 and use of non-st
 | INESSS, Quebec
Aim: To review the evidence on the use of NSAIDS in pediatric patients with confirmed or suspected COVID-19.
4/4/20
Personal protective equipm
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on appropriate PPE for healthcare workers providing routine intrapartum care during the COVID-19 outbreak and other respiratory pandemics.
4/3/20
3D Printing of N95 Respira
 | Ontario Health Quality
Aim: To examine the guidelines and published literature on the use of PAPRs as an alternative to N95 respirators in a health care setting.
4/3/20
Electronic follow-up of ch
Berg C, Nokleby H | Norwegian Institute of Public Health
Aim: To review the evidence on electronic follow-up of children and youth in childcare institutions.
4/3/20
Guidance on the optimal st
McLane P, Leal J | Alberta Health Services
Aim: To review the evidence on managing the clothing and personal items of healthcare workers across various health care settings to reduce the risk of self-contamination and to reduce the risk of transmitting the virus outside the hospital.
4/3/20
Guidance on the use of oxy
Sharpe H, Kania-Richmond A, Leal J | Alberta Health Services
Aim: To review the evidence on the risk of COVID-19 transmission associated with oxygen therapy.
4/3/20
Imaging and Clinical Featu
Cao Y, Liu X, Xiong L, et al. | J Med Virol
Aim: To explore reliable evidences for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2.
CLINICAL CHARACTERISTICS
4/3/20
Supportive approaches and
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on effective approaches with patients requiring psychiatric care and who have or are at risk of having COVID-19.
4/3/20
What is the efficacy of ey
Khunti K, et al. | Oxford COVID-19 Evidence Service Team
4/2/20
Medical Masks vs N95 Respi
Bartoszko JJ, Farooqi MAM, Alhazzani W, et al. | Influenza Other Respir Viruses
Aim: To compare medical masks to N95 respirators in preventing laboratory confirmed viral infection and respiratory illness including coronavirus specifically in health care workers.
INFECTION CONTROL
4/2/20
Question: Should the Roth
Greenhalgh, T | Oxford COVID-19 Evidence Service Team
4/2/20
What is the evidence for t
McQuillan R, Dozier M, Harpur A, et al. | UNCOVER
Aim: To review the evidence on the importance of outdoor transmission and of indoor transmission of COVID-19.
4/1/20
Aerosol generating procedu
Brurberg KG, Fretheim A | Norwegian Institute of Public Health
Aim: To review the evidence on the risk of aerosol-related transmission of SARS-CoV-2.
4/1/20
Comparative accuracy of or
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: What is the comparative accuracy of oropharyngeal and nasopharyngeal swabs for diagnosis of COVID-19?
4/1/20
Coronavirus Disease 2019 (
Seyedi SJ, Shojaeian R, Hiradfar M, et al. | Iran J Pediatr
Aim: To investigate different aspects of COVID-19 infection in pediatrics
CLINICAL CHARACTERISTICS
4/1/20
COVID-19 and nitrous oxide
 | INESSS, Quebec
Aim: To review the evidence on the use of nitrous oxide during childbirth in women with confirmed or suspected COVID-19.
4/1/20
Cytokine adsorbers for the
 | Health Technology Wales
Aim: To review evidence on the Jafron device or other haemoperfusion adsorption cartridges for the treatment of cytokine storm, particularly in people with COVID-19.
4/1/20
Does the use of hydrogen p
 | Health Technology Wales
Aim: To review evidence that reported levels of residual hydrogen peroxide (HP) after use of HP vapour to decontaminate PPE, in particular respirators and isolation/surgical gowns.
4/1/20
Guidance and recommendatio
Sharpe H | Alberta Health Services
Aim: To review the evidence on the recommendeduse of non-invasive ventilation in AHS acute care facilities during the COVID-19 pandemic.
4/1/20
In patients of COVID-19, w
Michelen M, Jones N, Stavropoulou C | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the symptoms and clinical features of mild and moderate cases of COVID-19.
4/1/20
In patients of COVID-19, w
Michelen M, Jones N, Stavropoulou C | Oxford COVID-19 Evidence Service Team
4/1/20
Intermittent Positive Airw
 | ECRI
Aim: To examine the safety and effectiveness of off-label use of these intermittent BiPAP and CPAP machines as temporary ventilator support for critically ill patients during ventilator shortages.
4/1/20
Single Ventilator Use to S
 | ECRI
Aim: To review the safety and efficacy of sharing a ventilator between multiple patients.
4/1/20
Winter and COVID-19 transm
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how seasonal changes could impact the COVID-19 pandemic.
3/31/20
A Systematic Review of COV
Park M, Cook AR, Lim JT, et al. | J Clin Med
Aim: To summarize the available evidence on transmission dynamics, severity, susceptibility and control measures to inform policymakers and leaders in formulating management guidelines and to provide directions for future research
3/31/20
Accuracy of strip-like for
Brassey J, Heneghan C | Oxford COVID-19 Evidence Service Team
Aim: Are strip-like thermometers accurate?
3/31/20
COVID-19 and Essential Reh
Chastenay M | INESSS, Quebec
Aim: To review the evidence on current intervention practices with children with ID, ASD, or PD internationally in the context of a pandemic.
3/31/20
COVID-19 and long-distance
Chastenay MH | INESSS, Quebec
Aim: To shed light on the identification of useful means or potential means to promote the maintenance of social interactions between caregivers and vulnerable people.
3/31/20
COVID-19 and Passive Thera
 | INESSS, Quebec
Aim: To evaluate the use of assive antibody therapy (convalescent plasma) for the treatment of COVID-19.
3/31/20
COVID-19 and the effects o
Chastenay MH | INESSS, Quebec
Aim: To document the harmful effects of the COVID-19 pandemic on the mental health of the population and the measures to put in place to counter these effects.
3/31/20
Hand washing for health ca
Kumar D, Loshak H | CADTH
Aim: To compare hand washing with soap and water to hand sanitation solutions, and to review handwashing guidelines for health care workers that come in contact with patients.
3/31/20
Radiographic Presentation
Bashir N | Lancet
Aim: To collate the available data documenting the radiographic features of COVID-19, and document their prevalence amongst the existing literature
CLINICAL CHARACTERISTICS
3/31/20
Shedding of beds in psychi
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on the criteria and the precautions to be implemented in the case of a load shedding in a psychiatric environment in the context of the health emergency linked to COVID-19 and the alternative measures to be implemented if necessary.
3/31/20
Strengthening the Role of
Fadlallah R, Daher N, El-Jardali F | Knowledge to Policy Center
Aim: To promote and strengthen the role of local and international NGOs in the COVID-19 response.
3/30/20
Masks During Aerosol Gener
Hafizi D, Walter M, MacDougall D | CADTH
Aim: To examine the clinical effectiveness of masks for clinicians and health care workers exposed to bioaerosols or infectious agents during ears, nose and throat (ENT) procedures.
3/30/20
Should people with chronic
Kalin, A  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on oral long-term immunosuppression in patients with respiratory disease.
3/30/20
The effect of COVID-19 on
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effects of the COVID-19 pandemic on healthcare workers in terms of infections.
3/29/20
Herbal medicine and patter
Lin A, Hye W, Jun Y, et al.  | Integr Med Res
Aim: To summarize and analyze the herbal formulae provided by the guidelines for their pattern identifications (PIs) and compositions of herbs to treat patients with COVID-19
CANDIDATE THERAPEUTICS
3/29/20
Models for redeploying sta
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on existing models for redeploying staff during the COVID-19 pandemic.
3/28/20
Maximising mobility in old
Hartmann-Boyce J, Davies N, Frost R, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for interventions to maximise mobility in older people, and minimise deterioration in activity and frailty levels.
3/28/20
Prone position for COVID-1
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence for the prone position in patients with COVID-19.
3/27/20
COVID-19 and the voluntary
 | INESSS, Quebec
Aim: To review the safety and effiacy of abortion methods during the COVID-19 pandemic.
3/27/20
Preventing respiratory ill
Rios P, Radhakrishnan A, Thomas SM, et al. | Oxford COVID-19 Evidence Service Team
3/26/20
Can social prescribing sup
Tierney S, Mahtani KR, Turk A | Oxford COVID-19 Evidence Service Team
3/26/20
Chloroquine and hydroxychl
Frie K, Gbinigie K | Oxford COVID-19 Evidence Service Team
3/26/20
Comparative accuracy of or
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the comparative accuracy of oropharyngeal and nasopharyngeal swabs to diagnose COVID-19.
3/26/20
Coronaviruses – a general
Aronson JK | Oxford COVID-19 Evidence Service Team
3/26/20
Is there any significant d
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
3/26/20
SARS-CoV-2 viral load and
Heneghan C, Brassey J, Jefferson T | Oxford COVID-19 Evidence Service Team
3/25/20
Can social prescribing sup
Tierney s, Mahtani KR, Turk A | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on how social prescribing can be best implemented within the current COVID-19 pandemic.
3/25/20
Chloroquine and hydroxychl
Frie K, Gbinigie K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effectiveness of chloroquine and hydroxychloroquine in treating COVID-19.
3/25/20
Colchicine [French]
 | INESSS, Quebec
Aim: To document the effect of colchicine on the inflammatory cascade accompanying certain severe forms of severe acute respiratory syndrome caused by coronaviruses.
3/25/20
COVID-19 Computed Tomograp
Bao C, Liu X, Zhang H, et al. | J Am Coll Radiol
Aim: To provide a more precise estimate of detection of COVID-19 by chest CT and report on the most common imaging findings on chest CT imaging.
CLINICAL CHARACTERISTICS
3/25/20
Laparoscopy during COVID-1
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the safety of laparoscopy during the COVID-19 pandemic.
3/25/20
Outcome of Coronavirus spe
Mascio DD, Khalil A, Saccone G, et al. | Am J Obs Gynecol
CLINICAL CHARACTERISTICS
3/25/20
Outcome of Coronavirus spe
Di Mascio D, Khalil A, Saccone G, et al. | Am J Obstet Gynecol
Aim: To report pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy
CLINICAL CHARACTERISTICS
3/25/20
Preventing respiratory ill
Rios P, Radhakrishnan A, Thomas SM, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify evidence on infection protection and control measures for adults aged 60 years and older in long-term care settings from systematic reviews.
3/25/20
Should we prescribe longer
Mahtani KR, MacKenna B, Spencer E | Oxford COVID-19 Evidence Service Team
3/25/20
Should we prescribe longer
Mahtani KR, MacKenna B, Spencer E | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on prescribing longer repeat prescriptions for patients with long-term conditions during a pandemic.
3/25/20
Supporting people with lon
Hartmann-Boyce J, Mahtani KR | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on management of LTCs during pandemics and national emergencies, to evaluate the indirect risks posed by these situations, and to summarise the strategies proposed to mitigate these risks.
3/25/20
Supporting people with lon
Hartmann-Boyce J, Mahtani KR | Oxford COVID-19 Evidence Service Team
3/24/20
Prevalence of Underlying D
Emami A, Javanmardi F, Pirbonyeh N, et al. | Arch Acad Emerg Med
Aim: To estimate the prevalence of underlying disorders in hospitalized COVID-19 patients.
CLINICAL CHARACTERISTICS
3/24/20
What is the efficacy of st
Greenhalgh T, Chan XH, Khunti K, et al. | Oxford COVID-19 Evidence Service Team
3/24/20
What is the efficacy of st
Greenhalgh T, Chan XH, Khunti K, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on respiratory protective measures e.g. use of face masks as PPE, to reduce droplet and airborne spread. 
3/23/20
Angiotensin converting enz
Aronson JK, Ferner RE | Oxford COVID-19 Evidence Service Team
3/23/20
Are there evidence-based w
Greenhalgh T, Kotze K, Van Der Westhuizen H | Oxford COVID-19 Evidence Service Team
3/23/20
COVID-19 and Amantadine/Ri
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of using Amantadine/Rimantadine in COVID-19 patients.
3/23/20
COVID-19 and Interferons [
 | INESSS, Quebec
Aim: To evaluate the administration of an interferon as monotherapy for the treatment of patients with a confirmed or suspected diagnosis of COVID-19.
3/23/20
COVID-19 and Oseltamivir [
 | INESSS, Quebec
Aim: To evaluate the use of oseltamivir for the treatment of patients with a confirmed or suspected diagnosis of COVID-19.
3/23/20
Drug therapies and COVID-1
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on drug therapies being used to combat COVID-19.
3/23/20
How accurate are the strip
Brassey J, Heneghan C | Oxford COVID-19 Evidence Service Team
3/23/20
How accurate is the wrist
Hoang U | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of wrist style BP cuffs.
3/23/20
How accurate is the wrist
Hoang U | Oxford COVID-19 Evidence Service Team
3/23/20
SARS-CoV-2, MERS-CoV og SA
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the risk of airborne transmission of SARS-CoV-2, MERS-CoV, and SARS-CoV.
3/23/20
Systematic review of COVID
Ludvigsson JF | Acta Paediatr
Aim: To review the evidence on COVID-19 incidence and disease course in children
CLINICAL CHARACTERISTICS
3/23/20
What is the evidence for a
O’Donovan J, Tanveer S, Jones N, et al. | Oxford COVID-19 Evidence Service Team
3/22/20
Medical college advice on
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by medical colleges regarding the COVID-19 pandemic.
3/22/20
Select international medic
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by international medical colleges regarding the COVID-19 pandemic.
3/22/20
Should ACE Inhibitors and
 | Singapore Ministry of Health
Aim: To review the evidence on the effect of ACE inhibitors and angiotensin II receptor blockers on patients with COVID-19.
3/22/20
Surgical specialties advic
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by surgical specialities regarding COVID-19.
3/20/20
COVID-19 and IECA [French]
 | INESSS, Quebec
Aim: To review the evidence on the use of ACE inhibitors and ARBs in the context of the COVID-19 pandemic.
3/20/20
COVID-19 and nonsteroidal
 | INESSS, Quebec
Aim: To review the evidence on the use of NSAIDS in patients with confirmed or suspected COVID-19.
3/20/20
COVID-19 and smoking: A sy
Vardavas CI, Nikitara K | Tob Induc Dis
Aim: To evaluate the association between smoking and COVID-19 outcomes including the severity of the disease, the need for mechanical ventilation, the need for intensive care unit (ICU) hospitalization and death.
CLINICAL CHARACTERISTICS
3/20/20
ECMO and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence and expert advice regarding the use of ECMO for COVID-19 patients.
3/20/20
Maximising mobility in old
Hartmann-Boyce J, Davies N, Frost R, Bussey J, Park S | Oxford COVID-19 Evidence Service Team
3/20/20
Rapid diagnosis of communi
Pluddemann A, Hobbs R, Mahtani KR, Heneghan C | Oxford COVID-19 Evidence Service Team
3/20/20
Spreading SARS-CoV-2 throu
Ferner RE, Murray PI, Aronson JK | Oxford COVID-19 Evidence Service Team
3/20/20
Telemedicine in intensive
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on telemedicine models or interventions associated with improved outcomes for people in the ICU.
3/20/20
What is the evidence for m
Nunan D, Brassey J | Oxford COVID-19 Evidence Service Team
3/20/20
What is the evidence for m
Nunan D, Brassey J | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effect of restricting and cancelling mass gatherings and sporting events on infectious diseases.
3/20/20
What is the evidence for s
Mahtani KR, Heneghan C, Aronson JK | Oxford COVID-19 Evidence Service Team
3/18/20
Accuracy of strip-like for
Brassey J, Heneghn C | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of strip-like forehead thermometers in detecting fevers.
3/18/20
Coronavirus in pregnancy a
Mullins E, Evans D, Viner RM, et al. | Ultrasound Obstet Gynecol
Aim: To guide treatment and prevention in women affected by COVID-19 during pregnancy in the current outbreak.
CLINICAL CHARACTERISTICS
3/18/20
Inhaled Steroid in Asthma
Hartmann-Boyce J, Hobbs R | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the relationship between the use of inhaled corticosteroids and COVID-19 infection.
3/18/20
Inhaled Steroids in Asthma
Hartmann-Boyce J, Hobbs R | Oxford COVID-19 Evidence Service Team
3/18/20
Managing Fever in adults w
Park S, Brassey J, Heneghan C, Mahtani K | Oxford COVID-19 Evidence Service Team
3/18/20
Managing Fever in adults w
Park S, Brassey J, Heneghan C, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on managing fever in adults with possible or confirmed COVID-19 in primary care.
3/17/20
COVID-19 Registered Trials
Aronson JK, Ferner RE, DeVito N, Heneghan C | Oxford COVID-19 Evidence Service Team
3/17/20
Hand Disinfectant and COVI
Ferner R | Oxford COVID-19 Evidence Service Team
3/16/20
NSAIDs in Acute Respirator
Heneghan C, Brassey J | Oxford COVID-19 Evidence Service Team
3/16/20
NSAIDs in Acute Respirator
Heneghan C, Brassey J | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence using NSAIDs in patients with acute respiratory infection.
3/16/20
Rapidly managing pneumonia
Heneghan C, Aronson J, Hobbs R, Mahtani K | Oxford COVID-19 Evidence Service Team
3/14/20
Coronavirus Disease 2019 (
Salehi S, Abedi A, Balakrishnan S, et al. | AJR Am J Roentgenol
Aim: To identify the CT characteristics of this life-threatening and rapidly spreading viral pneumonia, summarize key imaging findings in different stages of the disease, and define the evolution of CT findings associated with disease progression or clinical improvement. We also aim to investigate how CT findings correlate with patients’ age, severity of clinical symptoms, laboratory testing, and disease prognosis.
CLINICAL CHARACTERISTICS
3/13/20
Clinical, laboratory and i
Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. | Travel Med Infect Dis
Aim: To summarize the clinical, laboratory, and image features of COVID-19; to examine the outcome of COVID-19 cases, including risk factors, the proportion of patients requiring ICU and those with fatal outcomes; and to assess the prevalence of comorbidities among COVID-19 confirmed cases.
CLINICAL CHARACTERISTICS
3/13/20
Effectiveness of N95 Respi
Long Y, Hu T, Liu L, et al. | J Evid Based Med
Aim: To assess the effectiveness of N95 respirators versus surgical masks for prevention of influenza by collecting randomized controlled trials (RCTs)
INFECTION CONTROL
3/12/20
Prevalence of comorbiditie
Yang J, Zheng Y, Gou X, et al. | Int J Infect Dis
Aim: To assess the prevalence of comorbidities in the COVID-19 infection patients and the risk of underlying diseases in severe patients compared to non-severe patients.
CLINICAL CHARACTERISTICS
3/10/20
A systematic review on the
Cortegiani A, Ingoglia G, Ippolito M, et al. | J Crit Care
Aim: To evaluate the efficacy and safety of chloroquine and chloroquine-related formulations in patients with SARS-CoV-2 pneumonia and articles describing related in-vitro studies.
CANDIDATE THERAPEUTICS
3/1/20
Antimicrobial Copper Surfa
 | ECRI
Aim: To review the evidence on the effectiveness of antimicrobial copper surfaces in reducing health-associated infection risk.
3/1/20
Point-of-care smartphone a
 | Health Technology Wales
Aim: To review the evidence on digital applications for the diagnosis of actue respiratory disease.
3/1/20
The psychological impact o
Brooks SK, Webster RK, Smith LE, et al.  | Lancet
Aim: To review of the psychological impact of quarantine
INFECTION CONTROL
3/1/20
Use of personal protective
Chughtai AA, Khan W | J Infect Pub Health
Aim: To examine the use of PPE for respiratory infections in healthcare settings in Pakistan
INFECTION CONTROL
2/26/20
Potential Rapid Diagnostic
Pang J, Wang MX, Ang IYH, et al. | J Clin Med
Aim: To describe and assess the potential rapid diagnostics, vaccines and therapeutics for 2019-nCoV, based in part on the developments for MERS-CoV and SARS-CoV
CLINICAL CHARACTERISTICS
2/25/20
Effectiveness and safety o
Rios P, Radhakrishnan A, Antony J, et al. | Public Health Agency of Canada
Aim: To identify safe and effective medical countermeasures (e.g., antivirals/antibodies) to address the current outbreak of a novel coronavirus (COVID-19)
CANDIDATE THERAPEUTICS
2/14/20
Potential interventions fo
Zhang L, Liu Y | J Med Virol
Aim: To summarize therapeutic options available for the treatment of COVID-19
CANDIDATE THERAPEUTICS
2/6/20
Emerging and re-emerging h
Cupertino M, Rsende MB, Mayer NAJ, et al. | Asian Pacific Journal of Tropical Medicine
Aim: To review studies on the role of wild animals as reservoirs and/or dispersers of etiological agents of human infectious diseases in order to compile data on the main wild animals and etiological agents involved in zoonotic outbreaks
2/1/20
Drug targets for corona vi
Prajapat M, Sarma P, Shekhar N, et al. | Indian J Pharmacol
Aim: To describe protein structures that are potential targets for the development of CoV therapies
CANDIDATE THERAPEUTICS
2/1/20
SafeHaven Personal Hand Hy
 | ECRI
Aim: To review the efficacy of SafeHaven for reducing healthcare-associated infections.
2/1/20
SilvaClean Antimicrobial L
 | ECRI
Aim: To review the evidence that the use of SilvaClean reduces healthcare-associated infections (HAIs).