COVID-19 Evidence Reviews
as of 5/29/20

Our goal of cataloging COVID-19 evidence reviews is to capture the work of evidence synthesis groups in the US and around the world to maximize our collective contributions to patients, frontline clinicians, researchers, and policymakers during the COVID-19 pandemic and avoid duplicating efforts. This catalog is maintained by staff at the VA Evidence Synthesis Program based in Portland, OR. We identify new evidence reviews and reviews in progress through literature searching and through correspondence with colleagues and content experts. We welcome your feedback and questions; please reach out to us at covid19reviews@gmail.com

Completed Reviews
 
= living review
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
latest update
report
5/28/20
Scope, quality, and inclus
Dagens A, Sigfrid L, Cai E, et al. | BMJ
Aim: To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.
RECENTLY UPDATED
5/28/20
Neonates and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of newborn babies developing COVID-19.
RECENTLY UPDATED
5/28/20
Thermal imaging for detect
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of mass thermal imaging in identifying people with COVID-19.
RECENTLY UPDATED
5/28/20
Inpatient management of CO
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on inpatient management of COVID-19.
RECENTLY UPDATED
5/28/20
Ventilation use for COVID-
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the proportion of COVID-19 cases in intensive care units that require ventilation.
RECENTLY UPDATED
5/28/20
Validated tools to diagnos
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on which tools are validated to diagnose respiratory illness via telehealth.
RECENTLY UPDATED
5/28/20
Domestic and family violen
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of domestic and family violence during the COVID-19 pandemic.
RECENTLY UPDATED
5/28/20
Spirometry and transmissio
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on spirometry and whether it's an aerosol generating procedure, and the risk this procedure carries during the COVID-19 pandemic.
RECENTLY UPDATED
5/28/20
Temporary shared accommoda
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on temporary shared accomodations, particularly for people experiencing homelessness.
RECENTLY UPDATED
5/28/20
Intubation in the emergenc
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on safe practice of intubation in the emergency department during the COVID-19 pandemic.
RECENTLY UPDATED
5/28/20
Diabetes care during COVID
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on risk stratification approaches to identify risk level in diabetes patients and clinical pathways to support diabetes management and service delivery.
RECENTLY UPDATED
5/28/20
Rehabilitation needs of po
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the rehabilitation needs of post-acute COVID-19 patients and the appropriate timing of rehabilitation interventions.
RECENTLY UPDATED
5/28/20
Pulmonary rehabilitation a
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance for the provision of pulmonary rehabilitation for people recovering from COVID-19.
RECENTLY UPDATED
5/28/20
Fibrinolysis and PCI for S
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on fibrinolysis versus primary percutaneous coronary intervention in the treatment of ST-Elevation Myocardial Infarction (STEMI).
RECENTLY UPDATED
5/28/20
NIPPV and requirements
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how the increasing use of NIPPV to manage suspected or confirmed COVID-19 patients led to any additional guidance regarding the physical requirements and engineering services.
RECENTLY UPDATED
5/28/20
Asthma and COVID-19: risks
Hartmann-Boyce J, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the risk and management of people of asthma during the COVID-19 pandemic.
5/28/20
Reducing adverse impacts o
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on supporting health systems to reduce adverse impacts on people with a lived experience of mental health issues during the COVID-19 pandemic.
5/28/20
Large vessel occlusion str
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on large vessel occlusion stroke in patients with COVID-19.
5/28/20
Virtual care and telehealt
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effective use of telemedicine or virtual care in different clinical areas.
5/28/20
Preserving consumer and pa
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preservingc onsumer and patient partnership approaches during COVID-19.
5/28/20
Guidance and underlying ev
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence and guidelines on the use of PPE in COVID-19.
5/28/20
Renal replacement therapie
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of renal replacement therapies in intensive care units for patients with COVID-19?
5/28/20
Sanitising and covering la
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of santising and covering large medical equipment for COVID-19.
5/28/20
Transmission of respirator
Zhen J, Chan C, Schoonees A, et al. | South African Med J
Aim: To assess the abilities of different interventions to decrease the incidence of droplet-based infections among people using public ground transport.
5/28/20
Can video consultations re
Sutherland AE, Stickland J, Wee B | BMJ Support Palliat Care
Aim: To identify the highest currently available level of evidence to inform this major change in clinical practice.
5/28/20
The vaccine journey for CO
Checcucci E, Piramide F, Pecoraro A, et al. | Panminerva Med
Aim: To summarize the preliminary experiences and ongoing clinical trials of the major candidates and challenges of the vaccine strategies in humans.
5/28/20
Novelty in the gut: a syst
Kumar VCS, Mukherjee S, Harne PS, et al. | BMJ Open Gastroenterol
Aim: To perform a systematic review and meta-analysis on the GI symptoms of COVID-19.
5/27/20
Hydroxychloroquine or Chlo
Hernandez AV, Roman YM, Pasupuleti V, et al. | Ann Intern Med
Aim: To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19).
5/27/20
Non-steroidal anti-inflamm
Yousefifard M, Zali A, Zarghi A, et al. | Int J Clin Pract
Aim: To evaluate the efficacy and safety of various NSAIDs in viral respiratory infections so that we can reach a conclusion on which NSAID is best choice for COVID-19.
5/27/20
What explains the high rat
Durand-Moreau Q, Adisesh A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the transmission of SARS-CoV-2 in meat and poultry facilities.
5/27/20
Role of biological Data Mi
Albahri AS, Hamid RA, Alwan JK, et al. | J Med Syst
Aim: To obtain an overview of this critical virus, address the limitations of utilising data mining and ML algorithms, and provide the health sector with the benefits of this technique. 
5/27/20
International Guidelines A
Moletta L, Peirobon ES, Capovilla G, et al. | Int J Surg
Aim: To review the available recommendations published by general Surgery Societies and Health Institutions and evaluate the underlying Literature.
5/27/20
COVID-19 and newborn healt
Duran P, Berman S, Niermeyer S, et al. | Rev Panam Salud Publica
Aim: To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2.
5/27/20
Predictive Symptoms and Co
Jain V, Yuan JM  | Int J Public Health
Aim: To identify specific symptoms and comorbidities predicting severe COVID-19 and intensive care unit (ICU) admission.
RECENTLY UPDATED
5/26/20
The role of nicotine in CO
Hartmann-Boyce J, Lindson N | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the role of nicotine in COVID-19.
5/25/20
Assessment and management
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the assessment and management of suspected or confirmed COVID-19 patients presenting to the Emergency Department (ED).
5/25/20
Homelessness and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance to support health systems response to COVID-19 and associated risks for people experiencing homelessness.
5/25/20
Long-term clinical outcome
Ahmed H, Patel K, Greenwood D, et al. | J Rehabil Med
Aim: To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission.
5/24/20
Point-of-Care Diagnostic T
Ricco M, Ferraro P, Gualerzi G, et al. | J Clin Med
Aim: To explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak.
DIAGNOSTICS
5/23/20
COVID-19 and Liver Dysfunc
Youssef M, Hussein M, Attia AS, et al. | J Med Virol
Aim: To find the association between liver injuries and the severity of COVID?19 disease.
5/23/20
Laboratory findings of COV
Zhang Z, Hou Y, Li D, et al. | Scand J Clin Lab Invest
Aim: To assess laboratory findings in patients with COVID-19.
CLINICAL PRESENTATION
5/23/20
Herbal Medicine for the Tr
Ang L, Song E, Lee HW, et al. | J Clin Med
Aim: To evaluate the effectiveness and adverse events of herbal medicines for the treatment of COVID-19.
5/22/20
Predictors of mortality in
Tian W, Jiang W, Yao J, et al. | J Med Virol
Aim: To evaluate the risk factors associated with mortality in COVID?19.
5/22/20
Efficacy and safety of con
Devasenapathy N, Ye Z, Loeb M, et al. | CMAJ
Aim: To review the safety and efficacy of convalescent plasma in severe coronavirus disease 2019 (COVID-19) patients for guideline development
CANDIDATE THERAPEUTICS
5/22/20
Elevated N-terminal pro-br
Pranata R, Huang I, Lukito AA, et al. | Postgrad Med J
Aim: To assess the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and mortality in patients with COVID-19.
CLINICAL PRESENTATION
5/21/20
Clinical Outcomes in COVID
Antwi-Amoabeng D, Kanji Z, Ford B, et al. | J Med Virol
Aim: To summarize the baseline characteristics of COVID-19 patients who received tocilizumab in order to identify nuanced predictors of response to therapy and other clinical outcomes.
CANDIDATE THERAPEUTICS
5/21/20
Children are unlikely to b
Ludvigsson JF | Acta Paediatr
Aim: To review the evidence on the role of children in the transmission of SARS-CoV-2.
5/21/20
Video calls for reducing s
Noone C, McSharry J, Smalle M, et al. | Cochrane Database Syst Rev
Aim: To assess the effectiveness of video calls for reducing social isolation and loneliness in older adults. 
5/21/20
LIVING RAPID REVIEW: Risk
Goldstein KM, Ghadimi K, Mystakelis H, et al. | VA Evidence Synthesis Program
Aim: To review the evidence on the risk of transmitting SARS-CoV-2, SARS, MERS, and influenza with administration of drugs via nebulizer
VA ESP
5/20/20
Coronavirus Disease 2019 (
Aiello F, Afflitto GG, Mancino R, et al. | Eye
Aim: To review the evidence on the presence of SARS-CoV-2 in cornea, conjunctiva, lacrimal sac, and tears in patients with COVID-19.
5/20/20
SARS-COV-2 infection in ch
Liguoro I, Pilotto C, Bonanni M, et al. | Eur J Pediatr
Aim: To systematically review main clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric age.
CLINICAL PRESENTATION
5/20/20
Surgical Practice in the C
Hojaij FC, chinelatto LA, Book GHP, et al. | Clinics
Aim: To analyze different perspectives concerning the COVID-19 pandemic, aiming to provide recommendations that could guide surgeons and entities toward screening, elective and emergency surgeries, decision making, and operating room management. 
5/20/20
COVID-19 and risk factors
Flodgren GM, Vestrheim DF, Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the risk factors for severe COVID-19 disease.
5/20/20
Re-opening child-related f
Park M | Vancouver Coastal Health
Aim: To review the evidence on re-opening child-related facilities and gatherings.
5/19/20
The liver injury and gastr
Wang H, Qiu P, Liu J, et al. | Clin Res Hepatol Gastroenterol
Aim: To evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19.
CLINICAL PRESENTATION
5/19/20
Hydroxychloroquine effects
Sachdeva M, Mufti A, Maliyar K, et al. | J Am Acad Dermatol
Aim: To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment.
CANDIDATE THERAPEUTICS
5/19/20
How can healthcare workers
Jones L, Candy B, Roberts N, Ondruskova T, et al | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the management of delirium in patients with COVID-19 and the use of non-pharmacological approaches outside of critical care settings.
5/19/20
Immunosuppression and COVI
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk and management of people with immunosuppression and COVID-19.
RECENTLY UPDATED
5/19/20
Telehealth and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence or published standards on telehealth implementation during the COVID-19 pandemic.
RECENTLY UPDATED
5/19/20
Question: Should smartphon
Tarassenko L, Greenhalgh T | Oxford COVID-19 Evidence Service Team
Aim: Can we use smartphones to measure oxygen saturation?
5/19/20
COVID-19 pneumonia and pre
Kasraeian M, Zare M, Vafaei H, et al. | J Matern Fetal Neonatal Med
Aim: To review the evidence on pregnancy outcome and neonates regarding COVID-19 pneumonia.
5/19/20
Effects of coronavirus dis
Juan J, Gil MM, Rong Z, et al. | Ultrasound Obstet Gynecol
Aim: To evaluate the effects of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcomes by performing a systematic review of available published literature on pregnancies affected by COVID-19.
5/18/20
LIVING SYSTEMATIC REVIEW:
Mackey K, King VJ, Gurley S, et al. | VA Evidence Synthesis Program
Aim: To synthesize evidence on the role of ACE inhibitor and ARB use on patient outcomes in COVID-19 as well as evidence on the benefits and harms of initiating these medications to treat patients with COVID-19.
WHO COLLABORATIVE
VA ESP
5/18/20
Mast cell stabilisers, leu
Raymond M, Ching-A-Sue G, Van Hecke O | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on mast cell stabilizers, leukotriene antagonists, and antihistimines in COVID-19.
5/18/20
Psychiatric and neuropsych
Rogers JP, Chesney E, Oliver D, et al. | Lancet Psychiatry
Aim: To examine the two previous coronavirus epidemics, SARS and MERS, to identify the possible psychiatric and neuropsychiatric implications for the current pandemic. 
5/18/20
Persistent viral shedding
Gupta S, Parker J, Smits S, et al. | Colorectal Dis
Aim: To establish the incidence and timing of positive faecal samples for SARS-CoV-2 in patients with COVID-19.
5/18/20
Characterisation of COVID-
Mustafa NM, Selim LA | J Clin Virol
Aim: To analyse the disease characterisation in paediatric age group including the possibility of vertical transmission to the neonates.
CLINICAL PRESENTATION
5/18/20
Three months of COVID-19:
Rafiq D, Batool A, Bazaz MA | Rev Med Virol
Aim: To analyse information on progression of the pandemic in the past 3 months and systematically discusses the characteristics of SARS-CoV-2019 virus including its epidemiologic, pathophysiologic, and clinical manifestations.
CLINICAL PRESENTATION
5/18/20
Chest CT for Detecting COV
Xu B, Xing Y, Peng J, et al. | Eur Radiol
Aim: To perform a systematic review and meta-analysis regarding the diagnostic test accuracy of chest CT for detecting coronavirus disease 2019 (COVID-19).
DIAGNOSTICS
5/18/20
Hydroxychloroquine in pati
Singh AK, Singh A, Singh R, et al. | Diabetes Metab Syndr
Aim: To review the evidence on the efficacy of HCQ compared to the control in COVID-19 subjects on - a. viral clearance measured by reverse transcriptase polymerase chain reaction (RT-PCR) and, b. death due to all cause.
CANDIDATE THERAPEUTICS
5/18/20
Systematic review of the p
Farsalinos K, Barbouni A, Niaura R | Intern Emerg Med
Aim: To systematically examine the prevalence of current smoking among hospitalized patients with COVID-19 in China, considering the high-population smoking prevalence in China (26.6%).
5/15/20
ACEI/ARB Use and Risk of I
Zhang X, Yu J, Pan L, et al. | Pharmacol Res
Aim: To (1) determine whether use of ACRI/ARB is associated with an increase in likelihood of viral infectivity; (2) to investigate whether there are differences in severity and mortality between ACRI/ARB users and non- ACRI/ARB users; (3) and, in particular, to evaluate whether ACRI/ARB exposure was associated with a lower risk of mortality when compared to non-ACRI/ARB antihypertensive drug exposure. 
CANDIDATE THERAPEUTICS
5/15/20
Neurological manifestation
Montalvan V, Lee J, Bueso T, et al. | Clin Neurol Neurosurg
Aim: To review the neurological aspects of SARS-cov2 and other coronavirus, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease.
5/15/20
AGA Institute Rapid Review
Sultan S, Altayar O, Siddique SM, et al. | Gastroenterology
Aim: To summarize international data on the Gl and liver manifestations of COVID-19 infection and treatment.
CLINICAL PRESENTATION
5/15/20
Prognosis of COVID-19 in P
Oyelade T, Alqahtani J, Canciani G | Trop Med Infect Dis
Aim: To evaluate the severity and mortality in COVID-19 patients with underlying kidney and liver diseases.
CLINICAL PRESENTATION
5/14/20
Convalescent Plasma or Hyp
Valk SJ, Piechotta V, Chai KL, et al. | Cochrane Database Syst Rev
Aim: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID?19.
CANDIDATE THERAPEUTICS
5/14/20
Should azithromycin be use
Gbinigie K, Frie K | BJGP Open
Aim: To review the evidence for the effectiveness and safety of azithromycin in treating COVID-19.
CANDIDATE THERAPEUTICS
5/14/20
A Systematic Review Analyz
Chauhan RP, Gordon ML | Pathogens
Aim: To summarize the original research articles and case reports of all the four types of influenza viruses reported in swine populations worldwide.
5/14/20
Vertical Transmission of S
Yang Z, Liu Y | Am J Perinatol
Aim: To summarize currently available evidence on vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
5/13/20
Supporting adults bereaved
Mayland CR, Harding AJ, Preston N, et al. | J Pain Symptom Manage
Aim: To review and synthesise learning from previous literature focused on the impact on grief and bereavement during other infectious disease outbreaks.
5/13/20
Evidence summary of immuni
 | Health Information and Quality Authority, Ireland
Aim: To review the international evidence on immunity and the spread of the virus by children.
5/13/20
The role of biomarkers in
Kermali M, Khalsa RK, Pillai K, et al. | Life Sci
Aim: To evaluate different biomarkers to discover if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease.
5/12/20
Rapid Review: Diabetic ret
Ahmad E, Davies MJ, Khunti K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on screening for and managing diabetic retinopathy during the COVID-19 pandemic.
5/12/20
Should Baricitinib be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of baricitinib as a potential treatment for patients with COVID-19.
5/12/20
COVID-19 in hospitalized c
Streng A, Hartmann K, Armann J, et al. | Monatsschr Kinderheilkd
Aim: To summarize the current scientific evidence regarding the clinical presentation of COVID-19 in hospitalized children based on available case series from China.
CLINICAL PRESENTATION
5/12/20
The impact of 2019 novel c
Li JW, Han TW, Woodward M, et al. | Prog Cardiovasc Dis
Aim: To summarize available data on severity differences in acute cardiac injury and acute cardiac injury with mortality during the COVID-19 outbreak.
5/12/20
A Rapid Systematic Review
Chowdhury MS, Rathod J, Gernsheimer,J | Acad Emerg Med
Aim: To examine the evidence on chloroquine and hydroxychloroquine as treatments for COVID-19.
CANDIDATE THERAPEUTICS
5/12/20
Convalescent plasma transf
Rajendran K, Narayanasamy K, Rangarajan J, et al. | J Med Virol
Aim: To evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date.
CANDIDATE THERAPEUTICS
5/12/20
Systematic review of recom
Abdelrahman T, Ansell J, Brown C, et al. | BJS Open
Aim: To identify contemporary evidence relating to OR practice in the context of COVID?19.
5/12/20
Personal protective equipm
Jessop ZM, Dobbs TD, Ali SR, et al. | Br J Surg
Aim: To inform surgeons of appropriate PPE requirements, and to discuss usage, availability, rationing and future solutions.
INFECTION CONTROL
5/12/20
Use of Corticosteroids in
Veronese N, Demurtas J, Yang L, et al. | Front Med
Aim: To investigate the effectiveness of glucocorticoid therapy in patients with COVID-19.
CANDIDATE THERAPEUTICS
5/12/20
Prevalence, Severity and M
Alqahtani JS, Oyelade T, Aldhahir AM, et al. | PLoS ONE
Aim: To summarize the evidence on the potential severity and mortality risks caused by COVID-19 in patients with COPD.
5/12/20
SARS-CoV-2 (COVID-19): Wha
Mehta MS, Mytton OT, Mullins EWS, et al. | Clin Infect Dis
Aim: To summarise current understanding of the epidemiology and transmission dynamics of this coronavirus in children, in order to inform decisions regarding clinical and public health measures for children in the UK.
5/12/20
Obesity as a predictor for
Tamara A, Tahapary DL | Diabetes Metab Syndr
Aim: To study the impact of obesity to the prognosis and disease severity of COVID-19.
5/12/20
Coronavirus disease 2019 (
Yang Z, Wang M, Zhu Z, et al. | J Matern Fetal Neonatal Med
Aim: To summarize currently available evidence on maternal, fetal, and neonatal outcomes of pregnant women infected with Coronavirus Disease 2019 (COVID-19).
5/11/20
Taste Changes (Dysgeusia)
Aziz M, Perisetti A, Lee-Smith WM, et al. | Gastroenterology
Aim: To assess the presence of ageusia/dysgeusia among COVID-19 patients.
CLINICAL PRESENTATION
5/11/20
Can Antimalarials be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of antimalarials, particularly chloroquine or hydroxychloroquine, to treat patients with COVID-19.
5/11/20
Should Protease Inhibitors
 | Singapore Ministry of Health
Aim: To review the evidence on the use of protease inhibitors for treating COVID-19.
5/11/20
Preventing non-COVID-19 ho
Bobrovitz N, Lee J, Mahtani KR | Oxford COVID-19 Evidence Service Team
Aim: To identify a priority list of evidence-based medications for use in the community or emergency department that could prevent emergency hospital admissions among non-COVID patients.  
5/11/20
A systematic review on use
Patil VM, Singhal S, Masand N | Life Sci
Aim: To review the evidence on the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine.
CANDIDATE THERAPEUTICS
5/10/20
QT prolongation, torsades
Jankelson L, Karam G, Becker ML, et al. | Heart Rhythm
Aim: To conduct a systematic review of the arrhythmogenic effect of short courses of chloroquine or hydroxychloroquine.
CANDIDATE THERAPEUTICS
5/10/20
Delivering healthcare remo
Neubeck L, Hansen T, Jaarsma T | Eur J Cardiovasc Nurs
Aim: To bring together the evidence for remote healthcare during a quarantine situation period to support people living with cardiovascular disease during COVID-19 isolation.
5/10/20
Systematic review of the p
Farsalinos K, Barbouni A, Niaura R | Intern Emerg Med
Aim: To systematically examine the prevalence of current smoking among hospitalized patients with COVID-19 in China, considering the high-population smoking prevalence in China
5/10/20
Efficacy and safety of int
Liu M, Gao Y, Yuan Y, et al. | Pharmacol Res
Aim: To assess the efficacy and safety of Integrated Traditional Chinese and Western Medicine to corona virus disease 2019 (COVID-19). 
CANDIDATE THERAPEUTICS
5/10/20
Liver injury is associated
Parohan M, Yaghoubi S, Seraj A | Hepatol Res
Aim: To summarize available findings on the association between liver injury and severity of COVID-19 infection.
5/9/20
Anosmia as a presenting sy
Lechner M, Chandrasekharan D, Jumani K, et al. | Rhinology
Aim: To review the literature of SARS-CoV2 infection/COVID-19 and anosmia to help inform management of anosmia in healthcare works. 
CLINICAL PRESENTATION
5/8/20
Rapid review for the anti-
Li Z, Wang X, Cao D, et al. | Drug Discov Ther
Aim: To critically assess the potential anti-coronavirus effect of remdesivir on COVID-19 and other coronaviruses based on the most up-to-date evidence.
CANDIDATE THERAPEUTICS
5/8/20
What is the evidence for o
McQuillan R, Dozier M, Nundy R, et al. | UNCOVER
Aim: To review the evidence on the outdoor transmission of SARS-CoV-2 under the following different approaches: epidemiological, microbiological, mechanistic, and environmental.
5/8/20
Saliva sample for testing
Juvet LK, Lauvrak V | Norwegian Institute of Public Health
Aim: To investigate if there are studies supporting the use of salivary samples for detection of SARS-CoV-2, and if there are studies that can be used to calculate the diagnostic accuracy of salivary testing compared to nasopharyngeal or oropharyngeal swab samples.
5/8/20
Prevalence of depression,
Pappa S, Ntella V, Giannakas T, et al. | Brain Behav Immun
Aim: To synthesize and analyze existing evidence on the prevalence of depression, anxiety and insomnia among HCWs during the Covid-19 outbreak.
5/7/20
Transmission of SARS-CoV-2
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the transmission of SARS-CoV-2 via contact or droplets.
5/7/20
Occurrence, prevention, an
Kisely S, Warren N, McMahon L, et al. | BMJ
Aim: To examine the psychological effects on clinicians of working to manage novel viral outbreaks, and successful measures to manage stress and psychological distress.
5/7/20
Is oxygen an effective tre
Allsop M, Ziegler L, Fu Y, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for oxygen as a treatment option to alleviate the symptoms of breathlessness for patients dying with COVID-19 and to identify potential harms.
5/7/20
Activities delivered at ho
Lloyd-Williams M, Mogan C, Karen SR, et al. | Oxford COVID-19 Evidence Service Team
Aim: To establish the evidence for which non-technology based activities that can be delivered at home by family carers, are effective in maintaining cognitive function in people with dementia who are socially isolating during COVID-19
5/7/20
Activities delivered at ho
Lloyd-Williams M, Mogan C, Russel S, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To establish the evidence for which non-technology based activities that can be delivered at home by family carers, are effective in maintaining cognitive function in people with dementia who are socially isolating during COVID-19.
5/6/20
What is the evidence for t
Theodoratou E, Dozier M, Li X, et al. | UNCOVER
Aim: To review the evidence on COVID-19 transmission routes among infected children and adolescents.
5/6/20
Should Interleukin-6 Inhib
 | Singapore Ministry of Health
Aim: To review the evidence on the use of interleukin-6 (IL-6) inhibitors, particularly tocilizumab, to manage symptoms of patients with COVID-19.
5/6/20
COVID-19 in children with
LeBlanc A | medRxiv
UPDATED
5/6/20
Epidemiology of and Risk F
Chou R, Dana T, Buckley D, et al. | Ann Intern Med
Aim: To examine the burden of SARS-CoV-2, SARS-CoV-1, and Middle Eastern respiratory syndrome (MERS)-CoV on HCWs and risk factors for infection, using rapid and living review methods.
WHO COLLABORATIVE
5/5/20
Factors associated with mo
Martins-Filho PR, Tavares CSS, Santos VS | Eur J Intern Med
Aim: To comprehensively review studies of clinical and laboratory features of hospitalized patients with COVID-19.
CLINICAL PRESENTATION
5/5/20
COVID-19, Modern Pandemic:
Balla M, Merugu GP, Patel M, et al. | J Clin Med Res
Aim: To provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. 
5/5/20
BAME COVID-19 DEATHS – Wha
Razaq A, Harrison D, Karunanithi S, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence on plausible associations between ethnicity and COVID-19 incidence and adverse health outcomes in the general population and people working in health and social care.
5/5/20
A Rapid Scoping Review: Wh
Biro S | KFL&A Public Health
Aim: To review the evidence on the factors, considerations, and criteria that should be in place to limit infection risk while lifting restrictions at a regional level in Canada.
5/5/20
Impact of corticosteroid t
Li H, Chen C, Hu F, et al. | Leukemia
Aim: To determine safety and efficacy of corticosteroids in SARS-CoV-2, SARS-CoV, and MERS-CoV infections.
CANDIDATE THERAPEUTICS
5/5/20
Lifting Regional Restricti
Biro S | KFL&A Public Health
5/5/20
Rapid HTA of alternative d
 | Health Information and Quality Authority, Ireland
Aim: To identify a wide range of diagnostic tests for detecting and confirming COVID-19 cases.
5/4/20
Is the 'Lifelight' app ade
Tarassenko LJ, McManus R, Greenhalgh T | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of the Lifelight app to measure blood pressure.
5/4/20
Immunity after SARS-CoV-2
Flodgren GM | Norwegian Institute of Public Health
Aim: To review the evidence on immunity to COVID-19 after infection by SARS-CoV-2.
5/4/20
COVID-19: Case fatality ra
Juvet LK, Laake I, Vestrheim DF | Norwegian Institute of Public Health
Aim: To review the literature on the case fatality rate and infection fatality rate for serious cases of COVID-19.
5/4/20
Should Remdesivir be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of remdesivir as a potential treatment for patients with COVID-19.
5/3/20
Overcoming the bottleneck
Esbin MN, Whitney ON, Chong S, et al. | RNA
Aim: To present a collection of these recent advances in COVID-19 nucleic acid testing, including both peer-reviewed and preprint articles.
DIAGNOSTICS
5/2/20
A rapid systematic review
Chowdhury M, Rathod J, Gernsheimer J | Acad Emerg Med
Aim: To review literature currently available regarding the clinical use of CQ and HCQ as treatment in COVID-19 patients in an effort to catalog their recommendations and assess drug efficacy.
CANDIDATE THERAPEUTICS
5/2/20
Bacterial and fungal co-in
Rawson TM, Moore L, Zhu N, et al. | Clin Infect Dis
Aim: To explore and describe the current literature surrounding bacterial/fungal co-infection in patients with coronavirus infection.
5/1/20
Chloroquine / Hydroxychlor
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of cholorquine and hydroxychloroquine in COVID-19.
5/1/20
Vitamin D: A rapid review
Lee J, van Hecke O, Roberts N | Oxford COVID-19 Evidence Service Team
Aim: To review the clinical evidence that vitamin D has a role in preventing or treating COVID-19.
5/1/20
How have population-level
Li Y, Nair H, Kulkarni D, et al. | UNCOVER
Aim: To review the evidence on how population-level non-pharmaceutical interventions to reduce the transmission of COVID-19 is related to the reproduction number R.
4/30/20
Efficacy and safety of cur
Zhong H, Wang Y, Zhang Z, et al. | Pharmacol Res
Aim: To evaluate the efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome (MERS) besides COVID-19, in an attempt to identify promising therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients.
CANDIDATE THERAPEUTICS
4/30/20
The role of children in th
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the role of children in the transmission of SARS-CoV-2.
4/30/20
Smoking in acute respirato
Hartmann-Boyce J, Lindson N | Oxford COVID-19 Evidence Service Team
4/30/20
An updated systematic revi
Shiozawa P, Uchida RR | Braz J Psychiatry
Aim: To review the evidence on emergency psychological crisis intervention during the COVID-19 outbreak.
4/29/20
Is there an association be
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection.
4/29/20
Rapid Review: What are the
Asadi L | Alberta Health Services
Aim: To explore evidence based strategies beyond home self-isolation and use of centralized voluntary isolation centers (eg: wearing masks within the home; additional cleaning; testing, other) that have been used to successfully control focal COVID-19 outbreaks in other settings.
4/29/20
Rapid Review: The role of
Checkley S, Rogers L, Caffrey N, et al. | Alberta Health Services
Aim: To review the evidence that centralized voluntary isolation/quarantine centers (CVICs) reduce transmission and spread.
4/29/20
Rapid Review: what asympto
Boyd J | Alberta Health Services
Aim: To review the evidence on whether there are populations of asymptomatic individuals (e.g., population sampling; congregate living including LTC, vulnerable populations; patients being hospitalized, those associated with outbreaks, HCWs) that should be considered priority for screening for COVID 19 infection (with RTPCR), with the goal of surveillance and preventing spread within these populations.
4/29/20
Is there an association be
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection.
4/29/20
Is there an association be
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection. 
4/29/20
What is the evidence on et
McQuillan R, Dozier M, Theodoratou E, et al. | UNCOVER
Aim: To review the evidence on differences in COVID-19 incidence and outcomes based on ethnic variation.
4/29/20
A rapid review of evidence
Janssens GO, Mandeville HC, Timmermann B, et al. | Radiother Oncol
Aim: To derive evidence-based recommendations for the optimal utilisation of resources during unexpected shortage of radiotherapy capacity.
4/29/20
COVID-19 rapid response an
 | INESSS, Quebec
Aim: To identify alternative drugs to propofol currently used in the constitution of marketing authorization kits while taking into account current and anticipated stock-outs of alternative drugs.
4/28/20
Do we know the diagnostic
Bachelet VC | Medwave
Aim: To find and discuss studies on laboratory diagnostic tests and rapid viral diagnosis. 
DIAGNOSTICS
4/28/20
Evidence-based Strategies
 | ECRI
Aim: To review evidence and guidelines on interventions to supplement standard weaning practices to reduce ventilator time and avoid repeat intubation in patients with COVID-19.
4/28/20
What is the evidence for u
Gbinigie K, Frie K | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for the safety and effectiveness of using macrolides to treat COVID-19.
4/28/20
Should Favipiravir be Used
 | Singapore Ministry of Health
Aim: To review the evidence on the use of favipiravir for treating COVID-19.
4/28/20
Should Ibuprofen be Used f
 | Singapore Ministry of Health
Aim: To review the evidence on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, to manage symptoms of COVID-19.
4/28/20
Psychosocial impact of qua
Rohr S, Muller F, Jung F, et al. | Psychiatr Prax
Aim: To collect evidence on the psychosocial consequences of quarantine measures in severe coronavirus outbreaks prior to COVID-19. 
4/28/20
Hand cleaning with ash for
Paludan-Müller  AS, Boesen  K, Klerings  I, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the benefits and harms of hand cleaning with ash compared with hand cleaning using soap or other materials for reducing the spread of viral and bacterial infections.
INFECTION CONTROL
4/28/20
Environmental scan of lock
Park M | Vancouver Coastal Health
Aim: To review the evidence on lockdown de-escalation measures in response to COVID-19.
4/28/20
Management of acute behavi
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance on the management of acute behavioural disturbance during COVID-19.
4/27/20
Curating evidence on menta
Thombs BD, Bonardi O, Rice DB, et al. | J Psychosomatic Res
Aim: To evaluate (1) levels of mental health symptoms, prioritizing studies that assess changes in symptoms from pre-COVID-19 or compare concurrent samples between participants with different experiences with COVID-19 (e.g., those infected versus healthy comparison sample); (2) factors associated with levels or changes in symptoms during COVID-19, and (3) the effect of interventions on mental health symptoms during COVID-19.
4/27/20
What is the evidence about
Wilson, MG, Waddell K, Gauvin FP, et al. | McMaster Health Forum
Aim: To identify evidence on international and Canadian experiences with asymptomatic screening to identify COVID-19 cases and to prevent transmission.
4/27/20
How is immunosuppressive s
Minotti C, Tirelli F, Barbieri E, et al. | J Infect
Aim: To systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population.
4/27/20
Inhaled corticosteroids an
Halpin D, Singh D, Hadfield RM | Eur Respir J
Aim: To evaluate whether pre-morbid use or continued administration of inhaled steroids is a risk factor for adverse outcomes in acute respiratory infections due to COVID-19, SARS or MERS. 
WHO COLLABORATIVE
CANDIDATE THERAPEUTICS
4/27/20
Mortality in COVID-19 pati
Kernohan A, Boath A, Calderon M, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify relevant studies to inform evidence-based patient management and care pathway development.
4/27/20
Factors Informing Clinical
 | ECRI
Aim: To examine the effectiveness of triage systems for identifying disease severity and mortality risk to inform decisions on scarce resource allocation during pandemics.
4/25/20
Systematic review of impor
Chauhan R, Dessie ZG, Noreddin A, et al. | Pathogens
Aim: To highlight the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa to better understand the trend of emerging and re-emerging virus diseases within the African continent.
4/24/20
COVID-19 in cardiac arrest
Couper K, Taylor-Phillips S, Grove A, et al. | Resuscitation
Aim: To identify the potential risk of transmission associated with key interventions (chest compressions, defibrillation, cardiopulmonary resuscitation) to inform international treatment recommendations.
4/24/20
Does BCG vaccination prote
Soliman R, Brassey J, Pluddemann A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the current evidence about the protective effects of BCG vaccine against acute respiratory infections and COVID-19.
4/24/20
Portable or Temporary Nega
Kumar D, Severn M | CADTH
Aim: To identify available evidence on the clinical effectiveness of portable or temporary negative pressure rooms and related evidence-based guidelines for the management of people with active tuberculosis.
4/24/20
Plastic or reusable aeroch
Brett K, Walter M | CADTH
Aim: To examine the evidence regarding the clinical effectiveness of plastic or reusable aerochambers in multi-dose inhalers for patients requiring medication administration, as well as any evidence-based guidelines on the topic.
4/24/20
COVID-19 rapid response an
 | INESSS, Quebec
Aim: To examine the evidence on COVID-19 in pediatric clinical care.
4/23/20
Severe acute respiratory s
Castagnoli R, Votto M, Licari A, et al. | JAMA Pediatr
Aim: To evaluate currently reported pediatric cases of SARS-CoV-2 infection.
4/22/20
Prevalence and severity of
Hu Y, Sun J, Dai Z, et al. | J Clin Virol
Aim: To evaluate the risk factors of COVID-19. 
4/22/20
CT imaging features of 4,1
Zhu J, Zhong Z, Li H, et al. | J Med Virol
Aim: To systematically review the CT imaging features of COVID-19 in order to provide reference for clinical practice.
CLINICAL PRESENTATION
4/22/20
Barriers and facilitators
Houghton C, Meskell P, Delaney H, et al. | Cochrane Database of Systematic Reviews
Aim: To identify barriers and facilitators to healthcare workers' adherence to IPC guidelines for respiratory infectious diseases.
INFECTION CONTROL
4/22/20
Is it safe for patients wi
Kalin A, Waqar S, Ghouri N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To provide guidance to clinicians looking after patients with symptoms of COVID-19 who are thinking about fasting in Ramadan.
4/22/20
What prognostic clinical r
Urwin SG, Kandola G, Graziado S | Oxford COVID-19 Evidence Service Team
Aim: To provide a quick reference summary of prognostic clinical risk prediction scores that are currently available in an accessible format and methodologically suitable for use in the community following a potential infection with the SARS-CoV-2 virus causing COVID-19, or people with suspected or confirmed COVID-19.
4/22/20
What conditions could we p
Stravropoulou C, Palmer VJ, Burls A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To examine the evidence on the conditions that most often lead to potentially preventable unplanned hospital admissions that are manageable in primary care.
4/22/20
Cancer patients and resear
Moujaess E, Kourie HR, Ghosn M | Crit Rev Oncol Hematol
Aim: To expose the challenges of cancer management in the era of SARS-CoV-2, the epidemiological, clinical, pathological and radiological characteristics of the disease in cancer patients and its outcomes on this population.
CLINICAL PRESENTATION
4/22/20
Which occupations and acti
Carver C, Guyan M, Pierre M | UNCOVER
Aim: To review the evidence on which high proximity activites in the UK would benefit from mask wearing to reduce the transmission of COVID-19.
4/22/20
COVID-19 and the social an
Chastenay M | INESSS, Quebec
Aim: To review the evidence on social and mental health services to promote a return to normal life during the recovery phase of a pandemic or similar crisis.
4/22/20
Non-invasive ventilation a
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on community or home-based non-invasive ventilation (NIV) and inspiratory muscle training (IMT) for people with spinal cord injuries during COVID-19.
4/22/20
Rapid Review: What factors
Jelinski S, Mackay E | Alberta Health Services
Aim: To review the evidence on patient demographic or clinical factors that are associated with positive COVID-19 test results.
4/22/20
Are Non-Steroidal Anti-Inf
Erdmann R, Kania-Richmond A | Alberta Health Services
Aim: To review the evidence on whether patients who are on prescribed NSAIDS as chronic therapy should stop taking these drugs if they develop COVID-19.
4/22/20
Which COVID-19 patients ar
Sharpe H, McLane P | Alberta Health Services
Aim: To review the evidence on criteria or simple tools that can be used to determine which patients with suspected/confirmed COVID-19 are stable and appropriate for safe discharge from hospital or an alternate care centre.
4/22/20
Transmission of Acute Resp
Clement F  | University of Calgary
Aim: To review the clinical evidence for the risk of transmission of acute respiratory infections to health care workers caring for patients undergoing aerosol-generating medical procedures.
4/21/20
COVID-19 and pregnancy/lac
 | INESSS, Quebec
Aim: To examine the evidence on COVID-19 and breastfeeding.
4/21/20
A systematic review of pub
Strict A, Hartmann K, Armann J, et al. | Übersichten
Aim: To summarize the current scientific evidence on the clinical course of COVID-19 in hospitalized children.
4/21/20
Testing before surgery
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preoperative testing of COVID-19 for patients undergoing surgery.
UPDATED
4/21/20
Supportive treatment with
Alzghari SK, Acuna VS | J Clin Virol
Aim: To evaluate outcomes associated with TCZ treatment in patients with COVID-19.
CANDIDATE THERAPEUTICS
4/21/20
What is the efficacy and s
Greenhalgh T, Javid B, Knight M, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on tests to confirm or exclude exertional desaturation.
4/21/20
Clinical characteristics a
Chang T, Wu J, Chang L | J Formos Med Assoc
Aim: To collect current evidence about COVID-19 in children.
4/21/20
Antiviral therapy in manag
Yousefifard M, Zali A, Mohamed A, et al. | Arch Acad Emerg Med
Aim: To evaluate the efficacy of antiviral therapies in treatment of COVID-19.
CANDIDATE THERAPEUTICS
4/20/20
RAPID RESPONSE: Antithromb
Tao D, Maldonado E, Mackey K | VA Evidence Synthesis Program
Aim: To examine the incidence of thromboembolism and antithrombotic therapies for COVID-19 patients.
VA ESP
4/20/20
What clinical features or
Greenhalgh T, Treadwell J, Burrow R, et al. | Oxford COVID-19 Evidence Service Team
Aim: In people in the community with suspected or confirmed COVID-19, are there demographic features, other conditions, symptoms, or signs that are prognostic factors for 30-day all-cause mortality, ventilation, or ICU care?
4/20/20
Are interventions such as
Jones N, Carver C | Oxford COVID-19 Evidence Service Team
Aim: Does current evidence support social distancing of asymptomatic healthcare workers from other household members or other interventions specific to healthcare workers to reduce the risk of transmitting COVID-19?
4/20/20
Diabetic patients with COV
Roncon L, Zuin M, Rigatelli G, et al. | J Clin Virol
Aim: To assess the risk of ICU admission and morality risk in diabetic COVID-19 patients.
4/20/20
What is known about the sp
Waddell K, Gauvin FP, Wilson MG, et al. | McMaster Health Forum
Aim: To identify evidence on the spread and management of COVID-19 in non-health workplaces, including workplaces where light-touch services are offered such as government administration offices (e.g., Service Canada or Service Ontario) and social services (e.g., group homes for high-needs individuals).
4/20/20
Infrared Temperature Scree
 | ECRI
Aim: To examine the accuracy of external infrared temperature screening devices for identifying infected people.
4/20/20
Cloth Face Coverings Worn
 | ECRI
Aim: To review the evidence on the general public’s use of these face coverings for reducing the transmission risk of viral respiratory infection.
4/20/20
The clinical effectiveness
 | Health Technology Wales
Aim: To review the evidence on the effectiveness of virus and antibody tests to inform COVID-19 diagnosis.
4/20/20
What is the effectiveness
Theodoratou E, Dozier M, Guyan M, et al. | UNCOVER
Aim: To review the evidence on the efficacy of face masks in preventing respiratory transmission in the community.
4/20/20
Rapid Review: Effectivenes
Asadi L | Alberta Health Services
Aim: To review the evidence on the effectiveness of wearing medical masks, including home-made masks, to reduce the spread of COVID-19 in the community.
4/20/20
Which Patients with suspec
Cunningham C, Cook C | Alberta Health Services
Aim: To review the evidence on predictive tools or tests that can assist in deciding who is at risk of clinical deterioration and should be assessed in the emergency department.
4/19/20
Does the use of face masks
 | UNCOVER
Aim: To review the evidence on the effect of face masks in the general population in reducing the spread of infection.
4/19/20
Are homemade facemasks eff
McQuillan R, Narain A, Dozier M | UNCOVER
Aim: To review the evidence on the efficacy of homemade facemaks at reducing transmission of COVID-19 in community settings.
4/19/20
Cardiac injury is associat
Santoso A, Pranata R, Wibowo A, et al. | Am J Emerg Med
Aim: To explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia
4/18/20
COVID19 during pregnancy:
Gatta D, Nunzia A, Rizzo R, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the outcomes reported for pregnant patients with COVID 19. 
4/18/20
Clinical Characteristics o
Panahi L, Amiri M, Pouy S | Arch Acad Emerg Med
Aim: To review articles published on clinical manifestations and characteristics of children and infants with COVID-19.
CLINICAL PRESENTATION
4/17/20
Should Convalescent Plasma
 | Singapore Ministry of Health
Aim: To review the evidence on the use of convalescent plasma in patients with COVID-19.
4/17/20
Diabetes mellitus is assoc
Huang I, Lim MA, Pranata R | Diabetes Metab Syndr
Aim: To investigate the association between DM and poor outcome in patients with COVID-19 pneumonia.
4/17/20
Allocation of Scarce Resou
Romney D, Fox H, Carlson S, et al. | Disaster Med Public Health Prep
Aim: To locate and analyze U.S. State Crisis Standards of Care (CSC) documents to determine their prevalence and quality.
4/17/20
Therapeutic Management of
Tobaigy M, Qashgary M, Al-Dahery S, et al. | Infect Prev Pract
Aim: To report any evidence of therapeutics used for the management of COVID-19 patients in clinical practice since the emergence of the virus.
CANDIDATE THERAPEUTICS
4/17/20
Central nervous system man
Asadi-Pooya AA, Simani L | J Neruol Sci
Aim: To discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.
CLINICAL PRESENTATION
4/17/20
Virological and Clinical C
Sarma P, Kaur H, Kumar H, et al. | J Med Virol
Aim: To examine the evidence for the safety and efficacy of hydroxycholorquine in COVID-19.
CANDIDATE THERAPEUTICS
4/17/20
Benefits of Exercise on In
Song Y, Ren F, Sun D, et al. | Int J Environ Res Public Health
Aim: To summarize the recent scientific evidence that outlines the effects of exercise on influenza or pneumonia in older adults.
4/17/20
Pre-Treatment Mouth Rinses
Dulong C, Frey N, Walter M | CADTH
Aim: To summarize studies on the clinical effectiveness of using pre-dental treatment mouth rinses for patients with suspected SARS or COVID-19 in order to prevent virus transmission from patients to oral health care providers.
4/17/20
COVID-19: The relationship
Brurberg KG, Fretheim A | Norwegian Institute of Public Health
Aim: To review the evidence on the association between age, comorbidity, and disease severity in patients with COVID-19.
4/17/20
COVID-19 and Remdésivir [F
 | INESSS, Quebec
Aim: To evaluate the efficacy of remdesivir in post-exposure prophylaxis of SARS-Cov2 infection.
4/16/20
Biotherapies Directed Agai
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of using biotherapies directed againts IL-6 or its receptor in COVID-19.
4/16/20
COVID-19 and shortage of s
 | INESSS, Quebec
Aim: To review the evidence on alternative drugs for sedation during the COVID-19 pandemic.
4/16/20
COVID-19 and palliative ca
 | INESSS, Quebec
Aim: To review the evidence on palliative care and drug shortages during the COVID-19 pandemic.
4/16/20
Safety of Extended Use and
 | ECRI
Aim: To review the evidence on the safety of extending the use of N95 respirator masks.
4/16/20
Does physical exercise pre
McCall MC, Heneghan C, Nunan D | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effectiveness of physical exercise in preventing or treating acute respiratory infection.
4/16/20
What is the efficacy of ap
Coles B, Burton C, Khunti K, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the efficacy of protective gowns versus aprons in primary care settings.
4/16/20
Does physical exercise pre
McCall MC, Heneghan C, Nunan D | Oxford COVID-19 Evidence Service Team
Aim: To examine the current evidence about the effectiveness of physical exercise in preventing or treating acute respiratory infection.
4/16/20
What is the effectiveness
Coles B, Burton C, Khunti K, et al. | Oxford COVID-19 Evidence Service Team
Aim: What is the efficacy of aprons compared to gowns in primary care settings?
4/16/20
Clinical characteristics o
Zhu J, Ji P, Pang J, et al. | J Med Virol
Aim: To systematically review the clinical characteristics of Coronavirus disease 2019 (COVID?19).
CLINICAL PRESENTATION
4/16/20
Effectiveness of hydroxych
Hastings S, et al. | Alberta Health Services
Aim: To explore the evidence for and risks of using hydroxychloroquine (HQ) as a treatment and prophylaxis for SARS-CoV-2.
4/16/20
What clinical practice gui
Kostaras X | Alberta Health Services
4/16/20
Starting or resuming cance
Pujadas-Botey A | Alberta Health Services
Aim: To review the evidence on strategies for assessing patients who were infected with COVID-19 for suitability for starting or resuming cancer treatment.
4/15/20
Analysis of Maternal Coron
Muhidin S, Moghadam ZB, Vizheh M | Arch Acad Emerg Med
Aim: To clarify the impact of novel coronavirus disease (COVID-19) on pregnant patients and maternal and neonatal outcomes.
4/15/20
COVID-19 - Reducing Health
MacPherson F | BC Ministry of Health
Aim: To identify which infection prevention and control interventions, programs, infrastructure are most effective at reducing health care associated infections in Long Term Care facilities.
4/15/20
Personal protective equipm
Verbeek  JH, Rajamaki  B, Ijaz  S, et al. | Cochrane Database of Systematic Reviews
Aim: To evaluate which type of full?body PPE and which method of donning or doffing PPE have the least risk of contamination or infection for HCW, and which training methods increase compliance with PPE protocols.
INFECTION CONTROL
4/15/20
Clinical sensitivity and s
Hastings S, et al. | Alberta Health Services
Aim: To explore how the testing characteristics for the Alberta Health Services lab-developed test for COVID-19 differ between samples collected from nasal, nasopharyngeal, and throat swabs.
4/15/20
Clinical presentation of C
Lovato A, de Filippis C | Ear Nose Throat J
Aim: To perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. 
CLINICAL PRESENTATION
4/15/20
The proportion of patients
Zhou M, Qi J, Li X, et al. | Br J Haematol
Aim: To analyse the proportion of patients with thrombocytopenia in SARS?CoV, MERS?CoV and 2019?nCoV infections.
CLINICAL PRESENTATION
4/15/20
Extended Use and Layering
 | Ontario Health Quality
Aim: To examine the recommendations and literature on the extended use and layering of N95 respirators and use of expired personal protective equipment during the COVID-19 pandemic.
4/15/20
Mental health of healthcar
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the pyschological impact of COVID-19 on healthcare workers.
4/15/20
COVID-19 and general consi
 | INESSS, Quebec
Aim: To review the evidence on general considerations for cancer treatment in patients with COVID-19.
4/14/20
A systematic review of the
Shah S, Das S, Jain A, et al. | Int J Rheum Dis
Aim: To systematically review the role of CQ and HCQ in preventing the spread of COVID-19.
CANDIDATE THERAPEUTICS
4/14/20
Clinical characteristics o
Fu L, Wang B, Yuan T, et al. | J Infect
Aim: To better inform efforts to treat and control the current outbreak with a comprehensive characterization of COVID-19.
CLINICAL PRESENTATION
4/14/20
Arterial hypertension and
Zuin M, Rigatelli G, Zuliani G, et al. | J Infect
Aim: To evaluate the risk of death in COVID-19 infection patients with and without HT.
4/14/20
Coronavirus Disease 2019 (
Bao C, Liu X, Zhang H, et al. | J Am Coll Radiol
Aim: To provide a summary of evidence on detection of COVID-19 by chest CT and the expected CT imaging manifestations.
CLINICAL PRESENTATION
4/14/20
The effect of corticostero
Yang Z, Liu J, Zhou Y, et al. | J Infect
Aim: To further evaluate the influence of corticosteroids on patients with coronavirus infection.
CANDIDATE THERAPEUTICS
4/14/20
How can pandemic spreads b
Koshkouei M, Abel L, Pilbeam C | Oxford COVID-19 Evidence Service Team
Aim: To evaluate available measures to minimise the risk of infection spread among residents and staff within care home settings.
4/14/20
COVID-19 rapid evidence su
 | NICE
Aim: To assess the best available evidence to determine the risk of developing COVID-19 due to acute use of NSAIDs and if doing so can lead to increased risk of developing more severe symptoms of COVID-19.
4/14/20
Hydroxychloroquine for COV
Ferner RE, Aronson JK | Oxford COVID-19 Evidence Service Team
Aim: To examine the protocols and preliminary trial reports of early clinical trials involving hyroxychloroquine.
4/14/20
What is known about approa
Wilson MG, Gauvin FP, Waddell K, et al. | McMaster Health Forum
Aim: To identify evidence on strategies for conserving, re-using, and repurposing different kinds of masks.
4/14/20
Optimization of N95 Respir
 | CADTH
Aim: To summarize current recommendations about the use of N95 respirator masks.
4/14/20
Lopinavir/ritonavir: A rap
Dorward J, Gbinigie K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence for the use of Lopinavir/ritonavir (LPVr) as a treatment for COVID-19.
4/14/20
N-acetylcysteine: A rapid
Van Hecke O, Lee J | Oxford COVID-19 Evidence Service Team
Aim: To conduct a rapid review of NAC with specific emphasis on its potential for early administration in the community for patients at greater risk of severe COVID-19.
4/13/20
Likelihood of asymptomatic
Hastings S, et al. | Alberta Health Services
Aim: To explore the evidence supporting the possibility of asymptomatic transmission of SARS-CoV-2.
4/13/20
Triage tools for ICU admis
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the triage tools that are available to guide decisions about admission to ICU during COVID-19.
4/13/20
Tools to support communica
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on emerging tools that are being used to support communication between patients and their loved ones during the COVID-19 pandemic.
4/12/20
Palliative care and COVID-
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the organization of palliative care services during COVID-19 (or previous pandemics).
4/12/20
Dedicated or temporary COV
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of dedicated hospitals and wards exclusively for the use of COVID-19 patients.
4/12/20
The role and response of p
Etkind SN, Bone AE, Lovell N, et al. | J Pain Symptom Manage
Aim: To synthesise evidence for the role and response of palliative care and hospice teams to viral epi/pandemics, to inform the COVID-19 pandemic response.
CLINICAL PRESENTATION
4/11/20
Decontaminating N95 masks
O'Hearn K, Gertsman S, Sampson M, et al. | CADTH
Aim: To synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) on N95 FFR decontamination.
4/11/20
Modes of transmission for
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence about COVID-19 modes of transmission?
4/10/20
Continuous Positive Airway
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether continuous positive airway pressure (CPAP) and/or Bilevel Positive Airway Pressure (BiPAP) are aerosol generating, and to locate guidelines on the use of CPAP as a substitute for ventilators during the COVID-19 pandemic.
4/10/20
The possible of immunother
Aminjafari A, Ghasemi S | Int Immunopharmacol
Aim: To evaluate the existing evidence and experience related to immunotherapy for 2019-nCoV.
CANDIDATE THERAPEUTICS
4/10/20
School closure and managem
Viner RM, Russell SJ, Croker H, et al. | Lancet Child Adolesc Health
Aim: To identify what is known about the effectiveness of school closures and other school social distancing practices during coronavirus outbreaks.
INFECTION CONTROL
4/10/20
Clinical risk prediction t
Jelinski S | Alberta Health Services
Aim: To review the evidence on risk prediction tools to guide admission disposition and management decisions for patients with COVID-19 who are admitted to the hospital.
4/10/20
Patient risk stratificatio
McLane P | Alberta Health Services
Aim: To review the evidence on admission or safe discharge of patients with suspected or confirmed COVID-19 from the emergency department
4/10/20
Indicators for intubation
Sharpe H | Alberta Health Services
Aim: To review the evidence on clinical features that reliably indicate need for intubation or mechanical ventilation.
4/9/20
Quarantine alone or in com
Nussbaumer-Streit B, Mayr V, Dobrescu AI, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the effects of quarantine (alone or in combination with other measures) of individuals who had contact with confirmed cases of COVID19, who travelled from countries with a declared outbreak, or who live in regions with high transmission of the disease.
WHO COLLABORATIVE
INFECTION CONTROL
4/9/20
Should chloroquine and hyd
Gbinigie K, Kerstin F | BJGP Open
Aim: To establish the current evidence for the effectiveness of CQ and HCQ in treating COVID-19.
CANDIDATE THERAPEUTICS
4/9/20
Digital Stethoscope for Pa
Dulong C, MacDougall D | CADTH
Aim: To search for evidence-based guidelines related to the use of digital stethoscopes for pulmonary auscultation in patients with suspected or confirmed infectious disease.
4/9/20
SARS-CoV-2 Longevity on an
Kumar D, Walter M, Frey N | CADTH
Aim: To review the available evidence on the lifespan of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on different materials, as well as its potential for transmission via these materials
4/9/20
Rapid review of the use of
Stern D, Lopez-Olmedo N, Perez-Ferrer C, et al. | Salud publica de Mexico
Aim: To assess the effectiveness of using surgical masks in community settings to reduce the probability of infection by SARS-CoV-2 or other acute viral respiratory infection, compared to not using surgical masks
INFECTION CONTROL
4/9/20
COVID-19 and Lopinavir [Fr
 | INESSS, Quebec
Aim: To evaluate the use of the lopinavir-ritonavir combination in post-exposure prophylaxis of SARS-Cov2 infection.
4/9/20
COVID-19 and social safety
Chastenay M | INESSS, Quebec
Aim: To review the evidence on maintaining a community safety net for children and youth at risk of being abused during a pandemic.
4/8/20
Suppressing COVID-19 Epide
El-Jardali F, Fadlallah R, Daher N, et al. | Knowledge to Policy Center
Aim: To provide guidance for suppressing COVID-19 through community-centered care approach.
4/8/20
What is the effectiveness
Rios P, Radhakrishnan A, Antony J, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify safe and effective medical countermeasures to address the current outbreak of a novel coronavirus (COVID-19).
4/8/20
NEWS (or NEWS2) score when
Greenhalgh T, Treadwell J, Burrow R, et al. | Oxford COVID-19 Evidence Service Team
Aim: To establish the state of knowledge, ignorance and uncertainty in relation to the use of NEWS2 in the context of COVID-19 in primary care.
4/8/20
What is the role of imagin
Green K, Allen AJ, Suklan J | Oxford COVID-19 Evidence Service Team
Aim: To describe the approaches to clinical investigations following a negative RT-PCR results as described in guidelines from China, Italy, Spain, UK and US. 
4/8/20
RAPID RESPONSE: COVID-19:
Duan-Porter W | VA Evidence Synthesis Program
Aim: To explore the length of stay in the intensive care unit (ICU) and time on invasive mechanical ventilation for adult patients with COVID-19.
VA ESP
4/8/20
Differentiating viral from
Heneghan C, Pluddemann A, Mahtani KR | Oxford COVID-19 Evidence Service Team
4/8/20
Associations Between Immun
Russel B, Moss C, George G, et al. | Ecancermedicalscience
Aim: To examine the effects of immuno-suppressive and stimulating drugs on host immunity against COVID-19.
4/8/20
Maternal and Perinatal Out
Zaigham M, Andersson O | Acta Obstet Gynecol Scand
Aim: To summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy
CLINICAL PRESENTATION
4/8/20
Should people with chronic
Kalin A | Oxford COVID-19 Evidence Service Team
4/8/20
Diabetes and risks from CO
Hartmann-Boyce J, Morris E, Goyder C, et al. | Oxford COVID-19 Evidence Service Team
4/8/20
Managing diabetes during t
Hartmann-Boyce J, Morris E, Goyder C, et al. | Oxford COVID-19 Evidence Service Team
4/8/20
Re-infection and immunity
Hastings S | Alberta Health Services
Aim: To review the evidence on whether people with previous COVID-19 infection can become re-infected by the SARS-CoV-2 virus.
4/8/20
COVID-19 and diagnostic as
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on the effectiveness and feasibility of assessing autism spectrum disorder in children remotely in the context of the COVID-19 pandemic.
4/8/20
Psychological distress and
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on psychological distress and mental health in healthcare workers during the COVID-19 pandemic.
4/7/20
Gastrointestinal Manifesta
Cheung KS, Hung IF, Chan PP, et al. | Gastroenterology
Aim: To review the published gastrointestinal symptoms and detection of virus in stool, and also summarize data from a cohort of patients with COVID-19 in Hong Kong.
CLINICAL PRESENTATION
4/7/20
What is the evidence that
Khunti K | Oxford COVID-19 Evidence Service Team
4/7/20
Molecular and antibody poi
Green K, Graziadio S, Turner P, et al. | Oxford COVID-19 Evidence Service Team
Aim: To summarize the characteristics of current molecular and antibody diagnostic tests available to support the diagnosis and management of patients with suspected COVID-19.
4/7/20
N95 Equivalents as an Alte
 | Ontario Health Quality
Aim: To examine the recommendations and literature on N95 equivalents from other countries during the COVID-19 pandemic.
4/7/20
Cloth (Fabric) Masks as an
 | Ontario Health Quality
Aim: To examine the recommendations and literature on cloth (fabric) masks during the COVID-19 pandemic.
4/7/20
Powered Air Purifying Resp
 | Ontario Health Quality
Aim: To examine the guidelines and published literature on 3D printing of N95 respirators and face shields during the COVID-19 pandemic.
4/6/20
COVID-19: What proportion
Heneghan C, Brassey J, Jefferson T | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the proportion of COVID-19 cases that are asymptomatic.
4/6/20
COVID-19 rapid response an
 | INESSS, Quebec
Aim: To document the ethical guidelines for demonstrating treatment effectiveness by clinical research.
4/6/20
Cardiopulmonary resuscitat
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether cardiopulmonary resuscitation is aerosol generating.
4/6/20
Is a 14-day quarantine eff
McCall MC, Nunan D, Heneghan C | Oxford COVID-19 Evidence Service Team
4/4/20
Personal protective equipm
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on appropriate PPE for healthcare workers providing routine intrapartum care during the COVID-19 outbreak and other respiratory pandemics.
4/4/20
COVID-19 and use of non-st
 | INESSS, Quebec
Aim: To review the evidence on the use of NSAIDS in pediatric patients with confirmed or suspected COVID-19.
4/3/20
3D Printing of N95 Respira
 | Ontario Health Quality
Aim: To examine the guidelines and published literature on the use of PAPRs as an alternative to N95 respirators in a health care setting.
4/3/20
Electronic follow-up of ch
Berg C, Nokleby H | Norwegian Institute of Public Health
Aim: To review the evidence on electronic follow-up of children and youth in childcare institutions.
4/3/20
Imaging and Clinical Featu
Cao Y, Liu X, Xiong L, et al. | J Med Virol
Aim: To explore reliable evidences for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2.
CLINICAL PRESENTATION
4/3/20
What is the efficacy of ey
Khunti K, et al. | Oxford COVID-19 Evidence Service Team
4/3/20
Supportive approaches and
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on effective approaches with patients requiring psychiatric care and who have or are at risk of having COVID-19.
4/3/20
Guidance on the use of oxy
Sharpe H, Kania-Richmond A, Leal J | Alberta Health Services
Aim: To review the evidence on the risk of COVID-19 transmission associated with oxygen therapy.
4/3/20
Guidance on the optimal st
McLane P, Leal J | Alberta Health Services
Aim: To review the evidence on managing the clothing and personal items of healthcare workers across various health care settings to reduce the risk of self-contamination and to reduce the risk of transmitting the virus outside the hospital.
4/2/20
Medical Masks vs N95 Respi
Bartoszko JJ, Farooqi MAM, Alhazzani W, et al. | Influenza Other Respir Viruses
Aim: To compare medical masks to N95 respirators in preventing laboratory confirmed viral infection and respiratory illness including coronavirus specifically in health care workers.
INFECTION CONTROL
4/2/20
Question: Should the Roth
Greenhalgh, T | Oxford COVID-19 Evidence Service Team
4/2/20
What is the evidence for t
McQuillan R, Dozier M, Harpur A, et al. | UNCOVER
Aim: To review the evidence on the importance of outdoor transmission and of indoor transmission of COVID-19.
4/1/20
Aerosol generating procedu
Brurberg KG, Fretheim A | Norwegian Institute of Public Health
Aim: To review the evidence on the risk of aerosol-related transmission of SARS-CoV-2.
4/1/20
In patients of COVID-19, w
Michelen M, Jones N, Stavropoulou C | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the symptoms and clinical features of mild and moderate cases of COVID-19.
4/1/20
COVID-19 and nitrous oxide
 | INESSS, Quebec
Aim: To review the evidence on the use of nitrous oxide during childbirth in women with confirmed or suspected COVID-19.
4/1/20
Cytokine adsorbers for the
 | Health Technology Wales
Aim: To review evidence on the Jafron device or other haemoperfusion adsorption cartridges for the treatment of cytokine storm, particularly in people with COVID-19.
4/1/20
Does the use of hydrogen p
 | Health Technology Wales
Aim: To review evidence that reported levels of residual hydrogen peroxide (HP) after use of HP vapour to decontaminate PPE, in particular respirators and isolation/surgical gowns.
4/1/20
Winter and COVID-19 transm
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how seasonal changes could impact the COVID-19 pandemic.
4/1/20
Intermittent Positive Airw
 | ECRI
Aim: To examine the safety and effectiveness of off-label use of these intermittent BiPAP and CPAP machines as temporary ventilator support for critically ill patients during ventilator shortages.
4/1/20
Single Ventilator Use to S
 | ECRI
Aim: To review the safety and efficacy of sharing a ventilator between multiple patients.
4/1/20
In patients of COVID-19, w
Michelen M, Jones N, Stavropoulou C | Oxford COVID-19 Evidence Service Team
4/1/20
Coronavirus Disease 2019 (
Seyedi SJ, Shojaeian R, Hiradfar M, et al. | Iran J Pediatr
Aim: To investigate different aspects of COVID-19 infection in pediatrics
CLINICAL PRESENTATION
4/1/20
Comparative accuracy of or
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: What is the comparative accuracy of oropharyngeal and nasopharyngeal swabs for diagnosis of COVID-19?
4/1/20
Guidance and recommendatio
Sharpe H | Alberta Health Services
Aim: To review the evidence on the recommendeduse of non-invasive ventilation in AHS acute care facilities during the COVID-19 pandemic.
3/31/20
COVID-19 and the effects o
Chastenay MH | INESSS, Quebec
Aim: To document the harmful effects of the COVID-19 pandemic on the mental health of the population and the measures to put in place to counter these effects.
3/31/20
Shedding of beds in psychi
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on the criteria and the precautions to be implemented in the case of a load shedding in a psychiatric environment in the context of the health emergency linked to COVID-19 and the alternative measures to be implemented if necessary.
3/31/20
COVID-19 and long-distance
Chastenay MH | INESSS, Quebec
Aim: To shed light on the identification of useful means or potential means to promote the maintenance of social interactions between caregivers and vulnerable people.
3/31/20
Hand washing for health ca
Kumar D, Loshak H | CADTH
Aim: To compare hand washing with soap and water to hand sanitation solutions, and to review handwashing guidelines for health care workers that come in contact with patients.
3/31/20
Radiographic Presentation
Bashir N | Lancet
Aim: To collate the available data documenting the radiographic features of COVID-19, and document their prevalence amongst the existing literature
CLINICAL PRESENTATION
3/31/20
A Systematic Review of COV
Park M, Cook AR, Lim JT, et al. | J Clin Med
Aim: To summarize the available evidence on transmission dynamics, severity, susceptibility and control measures to inform policymakers and leaders in formulating management guidelines and to provide directions for future research
3/31/20
Accuracy of strip-like for
Brassey J, Heneghan C | Oxford COVID-19 Evidence Service Team
Aim: Are strip-like thermometers accurate?
3/31/20
COVID-19 and Passive Thera
 | INESSS, Quebec
Aim: To evaluate the use of assive antibody therapy (convalescent plasma) for the treatment of COVID-19.
3/31/20
COVID-19 and Essential Reh
Chastenay M | INESSS, Quebec
Aim: To review the evidence on current intervention practices with children with ID, ASD, or PD internationally in the context of a pandemic.
3/31/20
Strengthening the Role of
Fadlallah R, Daher N, El-Jardali F | Knowledge to Policy Center
Aim: To promote and strengthen the role of local and international NGOs in the COVID-19 response.
3/30/20
Should people with chronic
Kalin, A  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on oral long-term immunosuppression in patients with respiratory disease.
3/30/20
The effect of COVID-19 on
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effects of the COVID-19 pandemic on healthcare workers in terms of infections.
3/30/20
Systematic review and crit
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
3/30/20
Masks During Aerosol Gener
Hafizi D, Walter M, MacDougall D | CADTH
Aim: To examine the clinical effectiveness of masks for clinicians and health care workers exposed to bioaerosols or infectious agents during ears, nose and throat (ENT) procedures.
3/29/20
Herbal medicine and patter
Lin A, Hye W, Jun Y, et al.  | Integr Med Res
Aim: To summarize and analyze the herbal formulae provided by the guidelines for their pattern identifications (PIs) and compositions of herbs to treat patients with COVID-19
CANDIDATE THERAPEUTICS
3/29/20
Models for redeploying sta
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on existing models for redeploying staff during the COVID-19 pandemic.
3/28/20
Prone position for COVID-1
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence for the prone position in patients with COVID-19.
3/28/20
Maximising mobility in old
Hartmann-Boyce J, Davies N, Frost R, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for interventions to maximise mobility in older people, and minimise deterioration in activity and frailty levels.
3/27/20
COVID-19 and the voluntary
 | INESSS, Quebec
Aim: To review the safety and effiacy of abortion methods during the COVID-19 pandemic.
3/27/20
Preventing respiratory ill
Rios P, Radhakrishnan A, Thomas SM, et al. | Oxford COVID-19 Evidence Service Team
3/27/20
RAPID RESPONSE: Corticoste
Helfand M | VA Evidence Synthesis Program
Aim: To review the evidence for using corticosteroids to treat acute respiratory distress syndrome in patients with COVID-19.
VA ESP
3/26/20
SARS-CoV-2 viral load and
Heneghan C, Brassey J, Jefferson T | Oxford COVID-19 Evidence Service Team
3/26/20
Chloroquine and hydroxychl
Frie K, Gbinigie K | Oxford COVID-19 Evidence Service Team
3/26/20
Is there any significant d
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
3/26/20
Can social prescribing sup
Tierney S, Mahtani KR, Turk A | Oxford COVID-19 Evidence Service Team
3/26/20
Coronaviruses – a general
Aronson JK | Oxford COVID-19 Evidence Service Team
3/26/20
Working through the COVID-
Viswanath A, Monga P | J Clin Orthop Trauma
Aim: To discuss the issues revolving personal protection of musculoskeletal (MSK) healthcare workers, non-operative management of musculoskeletal conditions, remote consultations, trauma escalation stages, staff wellbeing and orthopaedic surgery for COVID-19 cases.
CLINICAL PRESENTATION
3/26/20
Chloroquine and hydroxychl
Singh AK, Singh A, Shaikh A, et al. | Diabets Metab Syndr
Aim: To review existing literature and relevant websites regarding these drugs and COVID-19, adverse effects related to drugs, and related guidelines.
CANDIDATE THERAPEUTICS
3/26/20
Comparative accuracy of or
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the comparative accuracy of oropharyngeal and nasopharyngeal swabs to diagnose COVID-19.
3/25/20
Chloroquine and hydroxychl
Frie K, Gbinigie K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effectiveness of chloroquine and hydroxychloroquine in treating COVID-19.
3/25/20
Can social prescribing sup
Tierney s, Mahtani KR, Turk A | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on how social prescribing can be best implemented within the current COVID-19 pandemic.
3/25/20
Should we prescribe longer
Mahtani KR, MacKenna B, Spencer E | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on prescribing longer repeat prescriptions for patients with long-term conditions during a pandemic.
3/25/20
Supporting people with lon
Hartmann-Boyce J, Mahtani KR | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on management of LTCs during pandemics and national emergencies, to evaluate the indirect risks posed by these situations, and to summarise the strategies proposed to mitigate these risks.
3/25/20
Colchicine [French]
 | INESSS, Quebec
Aim: To document the effect of colchicine on the inflammatory cascade accompanying certain severe forms of severe acute respiratory syndrome caused by coronaviruses.
3/25/20
Laparoscopy during COVID-1
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the safety of laparoscopy during the COVID-19 pandemic.
3/25/20
Outcome of Coronavirus spe
Di Mascio D, Khalil A, Saccone G, et al. | Am J Obstet Gynecol
Aim: To report pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy
CLINICAL PRESENTATION
3/25/20
Supporting people with lon
Hartmann-Boyce J, Mahtani KR | Oxford COVID-19 Evidence Service Team
3/25/20
Should we prescribe longer
Mahtani KR, MacKenna B, Spencer E | Oxford COVID-19 Evidence Service Team
3/25/20
Outcome of Coronavirus spe
Mascio DD, Khalil A, Saccone G, et al. | Am J Obs Gynecol
CLINICAL PRESENTATION
3/25/20
COVID-19 Computed Tomograp
Bao C, Liu X, Zhang H, Li Y, Liu J | J Am Coll Radiol
Aim: To provide a more precise estimate of detection of COVID-19 by chest CT and report on the most common imaging findings on chest CT imaging.
CLINICAL PRESENTATION
3/25/20
Preventing respiratory ill
Rios P, Radhakrishnan A, Thomas SM, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify evidence on infection protection and control measures for adults aged 60 years and older in long-term care settings from systematic reviews.
3/24/20
What is the efficacy of st
Greenhalgh T, Chan XH, Khunti K, et al. | Oxford COVID-19 Evidence Service Team
3/24/20
Prevalence of Underlying D
Emami A, Javanmardi F, Pirbonyeh N, et al. | Arch Acad Emerg Med
Aim: To estimate the prevalence of underlying disorders in hospitalized COVID-19 patients.
CLINICAL PRESENTATION
3/24/20
What is the efficacy of st
Greenhalgh T, Chan XH, Khunti K, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on respiratory protective measures e.g. use of face masks as PPE, to reduce droplet and airborne spread. 
3/23/20
Do weather conditions infl
Brassey J, Heneghan C, Mahtani K, et al. | Oxford COVID-19 Evidence Service Team
Aim: To explore if climate conditions may influence the spread of SARS-CoV-2.
3/23/20
Systematic review of COVID
Ludvigsson JF | Acta Paediatr
Aim: To review the evidence on COVID-19 incidence and disease course in children
CLINICAL PRESENTATION
3/23/20
How accurate is the wrist
Hoang U | Oxford COVID-19 Evidence Service Team
3/23/20
How accurate are the strip
Brassey J, Heneghan C | Oxford COVID-19 Evidence Service Team
3/23/20
Are there evidence-based w
Greenhalgh T, Kotze K, Van Der Westhuizen H | Oxford COVID-19 Evidence Service Team
3/23/20
Angiotensin converting enz
Aronson JK, Ferner RE | Oxford COVID-19 Evidence Service Team
3/23/20
What is the evidence for a
O’Donovan J, Tanveer S, Jones N, et al. | Oxford COVID-19 Evidence Service Team
3/23/20
Drug therapies and COVID-1
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on drug therapies being used to combat COVID-19.
3/23/20
COVID-19 and Interferons [
 | INESSS, Quebec
Aim: To evaluate the administration of an interferon as monotherapy for the treatment of patients with a confirmed or suspected diagnosis of COVID-19.
3/23/20
COVID-19 and Oseltamivir [
 | INESSS, Quebec
Aim: To evaluate the use of oseltamivir for the treatment of patients with a confirmed or suspected diagnosis of COVID-19.
3/23/20
COVID-19 and Amantadine/Ri
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of using Amantadine/Rimantadine in COVID-19 patients.
3/23/20
How accurate is the wrist
Hoang U | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of wrist style BP cuffs.
3/23/20
SARS-CoV-2, MERS-CoV og SA
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the risk of airborne transmission of SARS-CoV-2, MERS-CoV, and SARS-CoV.
3/22/20
Should ACE Inhibitors and
 | Singapore Ministry of Health
Aim: To review the evidence on the effect of ACE inhibitors and angiotensin II receptor blockers on patients with COVID-19.
3/22/20
Medical college advice on
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by medical colleges regarding the COVID-19 pandemic.
3/22/20
Select international medic
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by international medical colleges regarding the COVID-19 pandemic.
3/22/20
Surgical specialties advic
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by surgical specialities regarding COVID-19.
3/20/20
ECMO and COVID-19
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence and expert advice regarding the use of ECMO for COVID-19 patients.
3/20/20
Telemedicine in intensive
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on telemedicine models or interventions associated with improved outcomes for people in the ICU.
3/20/20
COVID-19 and IECA [French]
 | INESSS, Quebec
Aim: To review the evidence on the use of ACE inhibitors and ARBs in the context of the COVID-19 pandemic.
3/20/20
COVID-19 and nonsteroidal
 | INESSS, Quebec
Aim: To review the evidence on the use of NSAIDS in patients with confirmed or suspected COVID-19.
3/20/20
Spreading SARS-CoV-2 throu
Ferner RE, Murray PI, Aronson JK | Oxford COVID-19 Evidence Service Team
3/20/20
Maximising mobility in old
Hartmann-Boyce J, Davies N, Frost R, Bussey J, Park S | Oxford COVID-19 Evidence Service Team
3/20/20
What is the evidence for m
Nunan D, Brassey J | Oxford COVID-19 Evidence Service Team
3/20/20
What is the evidence for s
Mahtani KR, Heneghan C, Aronson JK | Oxford COVID-19 Evidence Service Team
3/20/20
Rapid diagnosis of communi
Pluddemann A, Hobbs R, Mahtani KR, Heneghan C | Oxford COVID-19 Evidence Service Team
3/20/20
COVID-19 and smoking: A sy
Vardavas CI, Nikitara K | Tob Induc Dis
Aim: To evaluate the association between smoking and COVID-19 outcomes including the severity of the disease, the need for mechanical ventilation, the need for intensive care unit (ICU) hospitalization and death.
CLINICAL PRESENTATION
3/20/20
What is the evidence for m
Nunan D, Brassey J | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effect of restricting and cancelling mass gatherings and sporting events on infectious diseases.
3/18/20
Managing Fever in adults w
Park S, Brassey J, Heneghan C, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on managing fever in adults with possible or confirmed COVID-19 in primary care.
3/18/20
Inhaled Steroid in Asthma
Hartmann-Boyce J, Hobbs R | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the relationship between the use of inhaled corticosteroids and COVID-19 infection.
3/18/20
Coronavirus in pregnancy a
Mullins, E; Evans, D; Viner, R M; O'Brien, P; Morris, E  | Ultrasound Obstet Gynecol
Aim: To guide treatment and prevention in women affected by COVID-19 during pregnancy in the current outbreak.
CLINICAL PRESENTATION
3/18/20
Managing Fever in adults w
Park S, Brassey J, Heneghan C, Mahtani K | Oxford COVID-19 Evidence Service Team
3/18/20
Inhaled Steroids in Asthma
Hartmann-Boyce J, Hobbs R | Oxford COVID-19 Evidence Service Team
3/18/20
Accuracy of strip-like for
Brassey J, Heneghn C | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of strip-like forehead thermometers in detecting fevers.
3/17/20
COVID-19 Registered Trials
Aronson JK, Ferner RE, DeVito N, Heneghan C | Oxford COVID-19 Evidence Service Team
3/17/20
Hand Disinfectant and COVI
Ferner R | Oxford COVID-19 Evidence Service Team
3/17/20
Epidemiology, causes, clin
Adhikari SP, Meng S, Wu YJ, et al. | Infect Dis Poverty
Aim: To conduct a scoping review to summarize and critically analyze all the published scientific articles regarding the new coronavirus in January 2020.
CLINICAL PRESENTATION
3/16/20
NSAIDs in Acute Respirator
Heneghan C, Brassey J | Oxford COVID-19 Evidence Service Team
3/16/20
Rapidly managing pneumonia
Heneghan C, Aronson J, Hobbs R, Mahtani K | Oxford COVID-19 Evidence Service Team
3/16/20
NSAIDs in Acute Respirator
Heneghan C, Brassey J | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence using NSAIDs in patients with acute respiratory infection.
3/14/20
Coronavirus Disease 2019 (
Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. | AJR Am J Roentgenol
Aim: To identify the CT characteristics of this life-threatening and rapidly spreading viral pneumonia, summarize key imaging findings in different stages of the disease, and define the evolution of CT findings associated with disease progression or clinical improvement. We also aim to investigate how CT findings correlate with patients’ age, severity of clinical symptoms, laboratory testing, and disease prognosis.
CLINICAL PRESENTATION
3/13/20
Clinical, laboratory and i
Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. | Travel Med Infect Dis
Aim: To summarize the clinical, laboratory, and image features of COVID-19; to examine the outcome of COVID-19 cases, including risk factors, the proportion of patients requiring ICU and those with fatal outcomes; and to assess the prevalence of comorbidities among COVID-19 confirmed cases.
CLINICAL PRESENTATION
3/13/20
Effectiveness of N95 Respi
Long Y, Hu T, Liu L, et al. | J Evid Based Med
Aim: To assess the effectiveness of N95 respirators versus surgical masks for prevention of influenza by collecting randomized controlled trials (RCTs)
INFECTION CONTROL
3/12/20
Prevalence of comorbiditie
Yang J, Zheng Y, Gou X, et al. | Int J Infect Dis
Aim: To assess the prevalence of comorbidities in the COVID-19 infection patients and the risk of underlying diseases in severe patients compared to non-severe patients.
CLINICAL PRESENTATION
3/10/20
A systematic review on the
Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. | J Crit Care
Aim: To evaluate the efficacy and safety of chloroquine and chloroquine-related formulations in patients with SARS-CoV-2 pneumonia and articles describing related in-vitro studies.
CANDIDATE THERAPEUTICS
3/1/20
The psychological impact o
Brooks, Samantha K; Webster, Rebecca K; Smith, Louise E; Woodland, Lisa; Wessely, Simon; Greenberg, Neil; Rubin, Gideon James | Lancet
Aim: To review of the psychological impact of quarantine
INFECTION CONTROL
3/1/20
Use of personal protective
Chughtai AA, Khan W | J Infect Pub Health
Aim: To examine the use of PPE for respiratory infections in healthcare settings in Pakistan
INFECTION CONTROL
3/1/20
Point-of-care smartphone a
 | Health Technology Wales
Aim: To review the evidence on digital applications for the diagnosis of actue respiratory disease.
3/1/20
Antimicrobial Copper Surfa
 | ECRI
Aim: To review the evidence on the effectiveness of antimicrobial copper surfaces in reducing health-associated infection risk.
2/26/20
Potential Rapid Diagnostic
Pang J, Wang MX, Ang IYH, et al. | J Clin Med
Aim: To describe and assess the potential rapid diagnostics, vaccines and therapeutics for 2019-nCoV, based in part on the developments for MERS-CoV and SARS-CoV
CLINICAL PRESENTATION
2/25/20
Effectiveness and safety o
Rios P, Radhakrishnan A, Antony J, et al. | Public Health Agency of Canada
Aim: To identify safe and effective medical countermeasures (e.g., antivirals/antibodies) to address the current outbreak of a novel coronavirus (COVID-19)
CANDIDATE THERAPEUTICS
2/14/20
Potential interventions fo
Zhang L, Liu Y | J Med Virol
Aim: To summarize therapeutic options available for the treatment of COVID-19
CANDIDATE THERAPEUTICS
2/6/20
Emerging and re-emerging h
Cupertino M, Rsende MB, Mayer NAJ, et al. | Asian Pacific Journal of Tropical Medicine
Aim: To review studies on the role of wild animals as reservoirs and/or dispersers of etiological agents of human infectious diseases in order to compile data on the main wild animals and etiological agents involved in zoonotic outbreaks
2/1/20
Drug targets for corona vi
Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A, Kumar H, Bansal S, Medhi B | Indian J Pharmacol
Aim: To describe protein structures that are potential targets for the development of CoV therapies
CANDIDATE THERAPEUTICS
2/1/20
SafeHaven Personal Hand Hy
 | ECRI
Aim: To review the efficacy of SafeHaven for reducing healthcare-associated infections.
2/1/20
SilvaClean Antimicrobial L
 | ECRI
Aim: To review the evidence that the use of SilvaClean reduces healthcare-associated infections (HAIs).